TALIPEXOLE
- CAS No.
- 101626-70-4
- Chemical Name:
- TALIPEXOLE
- Synonyms
- Domin;Talipexol;TALIPEXOLE;Talipexolum;Talipexolum [latin];Talipexol [spanish];TALIPEXOLE USP/EP/BP;6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine;6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine;6-Allyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepin-2-amine
- CBNumber:
- CB3153213
- Molecular Formula:
- C10H15N3S
- Molecular Weight:
- 209.31
- MDL Number:
- MFCD00867565
- MOL File:
- 101626-70-4.mol
- MSDS File:
- SDS
| Boiling point | 364.6±37.0 °C(Predicted) |
|---|---|
| Density | 1.167±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 7.22±0.20(Predicted) |
| FDA UNII | 7AM2J46Z1Y |
TALIPEXOLE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0009175 | TALIPEXOLE 95.00% | 101626-70-4 | 5MG | $490 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009175 | TALIPEXOLE 95.00% | 101626-70-4 | 10MG | $520 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009175 | TALIPEXOLE 95.00% | 101626-70-4 | 50MG | $920 | 2021-12-16 | Buy |
| AvaChem | 2567B | Talipexole | 101626-70-4 | 1g | $2900 | 2021-12-16 | Buy |
| Crysdot | CD31004840 | Talipexole 98+% | 101626-70-4 | 5mg | $76 | 2021-12-16 | Buy |
TALIPEXOLE Chemical Properties,Uses,Production
Description
Domin was launched in Japan for Parkinson's disease. The compound is readily accessible in two steps from I-allylhexahydro-4H-azepin4-one. Its antiparkinson activity resides in the fact that talipexole is a selective agonist for presynaptic dopamine D2 receptors with no D1 receptor activity. It is a clonidine-like α2-adrenoreptor agonist and has fewer GI side effects than bromocriptine the most widely used dopamine angonist. Also it is 70 times more potent than bromocriptine and has a more rapid onset of action. In addition to its anti-tremor activity there was a sedative effect but no emesis. The latter probably a result of talipexole's 5-HT3 receptor antagonistic activity. Its metabolites have no biological activity, there was no development of tolerence and its effect could be enhanced by L-dopa.
Originator
Boehringer Ingelheim (Germany)
Definition
ChEBI: 6-prop-2-enyl-4,5,7,8-tetrahydrothiazolo[4,5-d]azepin-2-amine is an azepine.
brand name
Domin
TALIPEXOLE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9126 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3500 | 55 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29796 | 68 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |