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Allantoin

Anti-inflammatory analgesic effects Chemical properties Uses Production methods
Allantoin
Allantoin structure
CAS No.
97-59-6
Chemical Name:
Allantoin
Synonyms
ALL;toin;nsc7606;Sebical;Alantan;Allantin;Alphosyl;Allantoi;Psoralon;Septalan
CBNumber:
CB3215461
Molecular Formula:
C4H6N4O3
Formula Weight:
158.12
MOL File:
97-59-6.mol

Allantoin Properties

Melting point:
230 °C (dec.) (lit.)
Boiling point:
283.17°C (rough estimate)
Density 
1.6031 (rough estimate)
refractive index 
1.8500 (estimate)
Flash point:
230-234°C
storage temp. 
2-8°C
solubility 
H2O: soluble0.1g/10 mL, clear, colorless
form 
Powder
pka
8.96(at 25℃)
color 
White
Water Solubility 
Slightly soluble in water. Freely soluble in alkalis
Decomposition 
230-234 ºC
Merck 
14,258
BRN 
102364
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
POJWUDADGALRAB-UHFFFAOYSA-N
CAS DataBase Reference
97-59-6(CAS DataBase Reference)
FDA 21 CFR
310.545
EWG's Food Scores
1
FDA UNII
344S277G0Z
NCI Dictionary of Cancer Terms
ALL
NIST Chemistry Reference
Urea, (2,5-dioxo-4-imidazolidinyl)-(97-59-6)
EPA Substance Registry System
Allantoin (97-59-6)
Cosmetics Info
Allantoin
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  1
RTECS  YT1600000
TSCA  Yes
HS Code  29332100
NFPA 704
0
1 0

Allantoin price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 05670 Allantoin ≥98.0% (N) 97-59-6 25g $43.2 2021-03-22 Buy
Sigma-Aldrich 05670 Allantoin ≥98.0% (N) 97-59-6 100g $64.5 2021-03-22 Buy
TCI Chemical A0211 Allantoin >98.0%(T) 97-59-6 25g $23 2021-03-22 Buy
TCI Chemical A0211 Allantoin >98.0%(T) 97-59-6 500g $174 2021-03-22 Buy
Alfa Aesar A15571 Allantoin, 98% 97-59-6 1000g $121 2021-03-22 Buy

Allantoin Chemical Properties,Uses,Production

Anti-inflammatory analgesic effects

Allantoin has anti-inflammatory analgesic effects, but it also has a weak partial paralysis effect, can effectively reduce stimuli of stimulus, can be used as a skin protectant and anti-irritant, can reduce skin irritation of cosmetic ingredients, China food and Drug Administration rank it as the first kind efficient active ingredient of skin care agent, now has been widely used in many products such as shampoo, sunscreen products, creams and lotions, shaving creams and oral care products.

Chemical properties

Colorless crystalline powder. Melting point is 238-240 ℃ (decomposition). Can be dissolved in hot water, hot alcohol and dilute sodium hydroxide solution, slightly soluble in water and alcohol, almost insoluble in ether and chloroform. Odorless, tasteless. In dry air is stable, prolonged boiling in the water. or strong base will be destroyed. pH of saturated aqueous solution is 5.5.
The above information is edited by the chemicalbook of Liu Yujie.

Uses

1. Allantoin can promote skin cell growth and rapid wound healing. Used as anti-ulcer drug, mixed with dry aluminum hydroxide gel, for gastrointestinal ulcers and inflammation. The product can soften keratin, making the skin retain moisture, moist and soft, is special effects of additive in cosmetic. Allantoin and its derivatives are the quality improver and additive of many household chemical products. Allantoin protein may be formulated anti-irritant, anti-dandruff, cleaning and wound healing scalp preparations, making hair soft, shiny and elastic. The product is an amphoteric compound, can bind to a variety of material form double salts, with dark, antiseptic, analgesic, deodorant, anti-oxidation effect, and therefore is household chemical products, additives of cosmetics such as freckle cream, acne solution, shampoo , soap, toothpaste, shaving lotion, convergence liquid and antiperspirant deodorant detergent. Allantoin also is a biochemical reagents.
2. For the roles such as skin care, oral products, anti-allergy, the treatment of skin ulcers promote wound healing.
3. Widely used in treatment of a variety of skin ulcers and trauma and additives of nutritional cosmetics.

Production methods

Allantoin presents in the sheath cyst fluid, fetal urine and some of the plants. However, the cost extracted Allantoin from these substances is too high. Currently synthesis methods of Allantoin are: potassium permanganate oxidation uric acid method: dichloroacetic acid and urea heated to synthesize Allantoin; direct condensation method of glyoxylic acid and urea.
1. technological process of dichloroacetic acid and urea as raw materials is as follows: The sodium methoxide solution and methanol were added into the reaction tank, and heated to 40-50 ℃, slowly dropwise added dichloroacetic acid, after added and reflux reaction for 2 h. Cooled to room temperature, filtered, washed with methanol and the filtrate was combined, washed, added methanol solution of sodium dimethoxyethane. The solution was reduced to dryness under reduced pressure , 2.8 portion of hydrochloric acid was added,heated and stirred into a paste in a water bath. Then heated to 90 ℃, and then cooled to about 10 ℃, filtered, 0.25 portion of hydrochloric acid and urea was added into , dissolved by heated, reacted at 80 ℃ for 2 h. Cooled and crystallization, and then maintained at 0 ℃ for above 3 h, centrifugation, washed ,spin-dried, dried to crude product. After The crude product was used 15 times of the water to recrystallize, Allantoin was obtained. As for the dichloroacetic acid, the total yield was 30.3%.
2. The direct condensation of glyoxylic acid and urea (glyoxylate derived by oxidation of glyoxal) operation example: (1) oxidation was in 500 ml four-hole boiling flask equipped with mechanical stirrer, condenser, thermometer and dropping funnel, added 193 g (1 mol) 30% glyoxal aqueous solution, controlled the internal temperature at 40 ± 2 ℃ and stirred to dropwise add 135.5 g ( 1 mol) 45% nitric acid, After addition, continued to stir at this temperature and reacted for 2-3 h, until reddish brown oxidation no longer escaped, the reaction solution was blue-green and immediately disappeared. Replaced by simple distillation apparatus, at about 2.76 kPa, the outside temperature did not exceed 60 ℃ and about 125 g water was evaporated, concentrate solution was standing overnight at room temperature, oxalic acid crystals were precipitated (dried to get 19 g, together 0.21 mol), concentration was 39% ). Continue to stir and react for about 8h at an internal temperature of 40 ± 2 ℃, the oxidation reaction was completed. (2) condensation In 500 ml three-hole boiling flask equipped with mechanical stirrer, condenser and thermomete, above 150 g glyoxylic acid aqueous solution was added, added 170 g (2.83 mol) urea and 23.3 g of concentrated hydrochloric acid, heated to an internal temperature of 80 ℃ under stirring. After about 15min urea was dissolved, the reaction solution was transparent, approximately another 30-45 min, the reactant appeared white cloudy, white precipitate was gradually increased, stirred at an inner temperature of 80 ℃ for 1 h, heating was stopped and the reactant was cooled to room temperature, The white precipitate was collected on a Buchner funnel, precipitated with cold water several times, obtained crude product of Allantoin. Used 1000 ml distilled water to recrystallize. 60-63% white fine crystalline Allantoin was obtained, melting point was 236 ℃ (decomposition). Calculated by glyoxal, the theoretical yield of Allantoin was 38-40% (weight yield was 103-108%).

Chemical Properties

White Solid

Originator

Allantoin ,Arocor Holdings Inc.

Uses

allantoin is a botanical extract said to be healing, calming, and soothing, it can also help protect the skin from harmful external factors (e.g., wind burn). It is considered an excellent temporary anti-irritant and is believed to stimulate new tissue growth, helping heal damaged skin. Allantoin is appropriate for sensitive, irritated, and acne skins. Derived from the comfrey root, it is considered non-allergenic.

Uses

wound healing agent

Uses

diuretic

Uses

Vulnerary; debriding agent. Purine metabolite via the uric acid pathway.

Definition

ChEBI: An imidazolidine-2,4-dione that is 5-aminohydantoin in which a carbamoyl group is attached to the exocyclic nitrogen.

Manufacturing Process

To a mixture of 13.14 kg 40% solution of glyoxal in water and a solution of 0.5 L of concentrated HCl in 3 L of water was added 1.8 g Co(NO3)2·6H2O. The mixture was heated at 50-60°C, to the solution was added 20 g of sodium nitrite and then at 40-60°C was added dropwise the mixture of 6 L of concentrated HNO3, 4.2 L of water and 30 g of sodium nitrite. The product obtained was mixed with 2.4 kg ammonium sulfate and filtrated. The filtrate was heated with 14.5 kg urea at 70°C for 10 hours. Allantoin was filtrated and recrystallized from the water; M.P. 233-235°C.

Therapeutic Function

Vulnerary, Antiulcer (topical), Antipsoriatic

Purification Methods

It crystallises from water or EtOH [Hartman et al. Org Synth Coll Vol II 21 1943]. [Beilstein 25 III/IV 4071.]

Allantoin Preparation Products And Raw materials

Raw materials

Preparation Products


Allantoin Suppliers

Global( 605)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Connect Chemicals GmbH
+49 2102 2077-39
+49 2102 2077-40 inquiries@connectchemicals.com Germany 265 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Tianjin Zhongxin Chemtech Co., Ltd.
022-66880623
022-66880086 sales@tjzxchem.com CHINA 537 58
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1004 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58

View Lastest Price from Allantoin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-06 Allantoin
97-59-6
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-12-01 Allantoin
97-59-6
US $1.70 / Kg/Bag 10g 99% 10000kg Hebei Crovell Biotech Co Ltd
2021-11-30 Allantoin
97-59-6
US $15.00 / KG 1KG 99% 1000kg Baoji Guokang Bio-Technology Co., Ltd.

Allantoin Spectrum


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