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ZAPRINAST

ZAPRINAST
ZAPRINAST
CAS No.
37762-06-4
Chemical Name:
ZAPRINAST
Synonyms
ZAPRINAST;M&B 22,948;M AND B 22948;Phenylaza purinon;M-EPSILON-TB22948;Zaprinast (M&B 22948);3,6-dihydro-5-(2-propoxyphenyl)-;2-(o-Propoxyphenyl)-8-azapurin-6-one;8-Aza-2-(2-propoxyphenyl)-6-purinone;2-(2-Propoxyphenyl)-8-azahypoxanthine
CBNumber:
CB3215496
Molecular Formula:
C13H13N5O2
Formula Weight:
271.27
MOL File:
37762-06-4.mol

ZAPRINAST Properties

Melting point:
237-238°C dec.
RTECS 
XZ6157358
storage temp. 
Store at RT
solubility 
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.11 mg/mL
form 
solid
color 
white
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

ZAPRINAST price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 684500 Zaprinast 37762-06-4 25mg $64.4 2018-11-20 Buy
Sigma-Aldrich Z0878 Zaprinast solid 37762-06-4 25mg $73.6 2018-11-13 Buy
Alfa Aesar J63326 Zaprinast, 98+% 37762-06-4 10mg $50.4 2018-11-13 Buy
Alfa Aesar J63326 Zaprinast, 98+% 37762-06-4 50mg $228 2018-11-13 Buy
Cayman Chemical 10010421 Zaprinast ≥98% 37762-06-4 10mg $21 2018-11-19 Buy

ZAPRINAST Chemical Properties,Uses,Production

Chemical Properties

Yellow-Orange Crystalline Powder

Uses

cGMP phosphodiesterase inhibitor

Uses

A selective inhibitor of cyclic-GMP phosphodiesterase (PDE V, calmodulin insensitive). Since cGMP mediates the vasorelaxant action of nitric oxide, as well as the natriuretic and diuretic effect of at rial natriuretic factor (ANF) through the activation of PKG (cGMP dependent protein kinase), such inhibitors may display vasodilating, relaxant, and diuretic effects. These compounds may prove useful in treating hypertension and congestive heart failure.

Biological Activity

Phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC 50 values are 0.15, 0.76, 12.0 and 29.0 μ M respectively).

ZAPRINAST Preparation Products And Raw materials

Raw materials

Preparation Products


ZAPRINAST Suppliers

Global( 42)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15926 69
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32492 50
Spectrum Chemical Manufacturing Corp. 021-67601398,18616765336,QQ:3003443156
021-57711696 mkt@spectrumchina.net China 9779 60
Dalian Meilun Biotech Co., Ltd. 0411-66771943;0411-66771942
0411-66771945 sales@meilune.com China 4150 58
Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979
021-33632979 zijuecai@targetmol.com China 2999 58
Sigma-Aldrich 021-61415566 800-819-3336(Tel) 400-620-3333(Mobile)
021-61415567 orderCN@sial.com China 28593 80
EMMX Biotechnology LLC 888-539-0666
888-539-0666 info@emmx.com United States 8472 60
Target molecule Corp. 857-239-0968
857-239-8801 service1@targetmol.com United States 2566 60
Shanghai Haohong Pharmaceutical Co., Ltd. 400-8210-725/ QQ: 4008210725
021-58955996 marketing@leyan.com.cn China 26052 58

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