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L(+)-2-Aminobutyric acid

CAS No.
1492-24-6
Chemical Name:
L(+)-2-Aminobutyric acid
Synonyms
AMINOBUTYRIC ACID;L-2-AMINOBUTYRIC ACID;2-AMINOBUTANOIC ACID;L-ABU;H-ABU-OH;L-ALPHA-AMINOBUTYRIC ACID;L-2-AMINOBUTANOIC ACID;L-2-Abu;L-ABU-OH;Z-&gamma
CBNumber:
CB3741533
Molecular Formula:
C4H9NO2
Molecular Weight:
103.12
MDL Number:
MFCD00064415
MOL File:
1492-24-6.mol
MSDS File:
SDS
Last updated:2025-01-27 09:38:02

L(+)-2-Aminobutyric acid Properties

Melting point 300 °C
Boiling point 215.2±23.0 °C(Predicted)
alpha 21.6 º (c=2, 5N HCl)
Density 1.2300 (estimate)
refractive index 1.4650 (estimate)
storage temp. room temp
solubility 22.7 g/100 mL (22°C)
pka 2.29(at 25℃)
form Crystalline Powder
color White to beige
biological source Porcine kidney
microbial
plant
Water Solubility 22.7 g/100 mL (22 ºC)
Merck 14,428
BRN 1720935
InChIKey QWCKQJZIFLGMSD-VKHMYHEASA-N
CAS DataBase Reference 1492-24-6(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 0QAJ5KN9IM
ATC code N03AG03
NIST Chemistry Reference (l)-2-Aminobutanoic acid(1492-24-6)
EPA Substance Registry System Butanoic acid, 2-amino-, (2S)- (1492-24-6)
UNSPSC Code 12352209
NACRES NA.75

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H317
Precautionary statements  P280
Hazard Codes  Xi
Risk Statements  43
Safety Statements  36/37
WGK Germany  3
Hazard Note  Irritant
TSCA  Yes
HS Code  29224999
NFPA 704
0
1 0

L(+)-2-Aminobutyric acid price More Price(59)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A1879 L-2-Aminobutyric acid ≥99% (titration) 1492-24-6 1g $120 2024-03-01 Buy
Sigma-Aldrich A1879 L-2-Aminobutyric acid ≥99% (titration) 1492-24-6 5g $396 2024-03-01 Buy
TCI Chemical A0826 (S)-(+)-2-Aminobutyric Acid >99.0%(T) 1492-24-6 1g $30 2024-03-01 Buy
TCI Chemical A0826 (S)-(+)-2-Aminobutyric Acid >99.0%(T) 1492-24-6 5g $84 2024-03-01 Buy
Alfa Aesar J11079 L-alpha-Amino-N-Butyric acid, 98+%, Affymetrix/USB 1492-24-6 1g $62.07 2021-12-16 Buy
Product number Packaging Price Buy
A1879 1g $120 Buy
A1879 5g $396 Buy
A0826 1g $30 Buy
A0826 5g $84 Buy
J11079 1g $62.07 Buy

L(+)-2-Aminobutyric acid Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Solid

Uses

L-(+)-2-Aminobutyric acid is used in the biosynthesis of nonribosomal peptides. It acts as a receptor antagonist. It is also used as a chiral reagent. Further, it is used in the determination of substrate of glutamyl cysteine acid synthase. In addition to this, it is also utilized as a drug intermediate.

Uses

aminobutyric acid is an amino acid with water-binding properties and possible anti-inflammatory capacities.

Definition

ChEBI: An optically active form of alpha-aminobutyric acid having L-configuration.

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 450, 1946 DOI: 10.1021/ja01207a032

General Description

L-2-Aminobutyric acid is synthesized from L-threonine and L-aspartic acid through a ?-transamination reaction. It is an L-alanine analogue with an ethyl side chain.

Biochem/physiol Actions

L-α-Aminobutyric acid (AABA) is an isomer of the non-natural amino acid aminobutyric acid with activity in the γ-glutamyl cycle that regulates glutathione biosynthesis. Recently AABA has been studied as a supplement to in vitro maturation medium (NCSU 23 medium) for culture of oozytes and embryos. This product has been qualified for use in cell culture. AABA is also used as a substitute amino acid for alanine in studies on peptide function.

Synthesis

The preparation of l-2-aminobutyric acid (l-ABA) is mainly achieved by chemical synthesis or enzymatic conversion. In chemical methods, synthesis of l-ABA has been extensively reported, including ammonolysis of α-halogen acid, reduction reaction, ammoniation hydrolysis reaction and butanone acid reduction. However, the obvious disadvantages of chemical synthesis, such as poor selectivity, harsh reaction conditions, various byproducts, and the difficulty in separation and purification, limited its development. It is reported that l-ABA was synthesized in a transamination reaction from α-ketobutyric acid and l-aspartic acid as substrates using aromatic aminotransferase or produced from α-ketobutyric acid and benzylamine using ω-aminotransferase. l-ABA could also be produced from the reduction of α-keto acids with l-leucine dehydrogenase or glutamate dehydrogenase[1].

Purification Methods

Crystallise butyrine from aqueous EtOH, and the melting point depends on heating rate but has m 303o in a sealed tube. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2399 IR: 2401 1961, Beilstein 4 III 1294, 4 IV 2584.]

References

[1] Xu, Jian-Miao et al. “Fermentative production of the unnatural amino acid L-2-aminobutyric acid based on metabolic engineering.” Microbial cell factories vol. 18,1 43. 28 Feb. 2019, doi:10.1186/s12934-019-1095-z.

L(+)-2-Aminobutyric acid Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 658)Suppliers
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View Lastest Price from L(+)-2-Aminobutyric acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-2-Abu pictures 2025-02-10 L-2-Abu
1492-24-6
US $0.00-0.00 / kg 1kg 99% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
L(+)-2-Aminobutyric acid pictures 2025-02-10 L(+)-2-Aminobutyric acid
1492-24-6
US $50.00 / kg 1kg 99 5000 Hebei Zhuanglai Chemical Trading Co Ltd
L(+)-2-Aminobutyric acid pictures 2025-02-08 L(+)-2-Aminobutyric acid
1492-24-6
US $99.00-66.00 / kg 0.00100000kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
  • L-2-Abu pictures
  • L-2-Abu
    1492-24-6
  • US $0.00-0.00 / kg
  • 99%
  • Sichuan HongRi Pharma-Tech Co.,Ltd
L-2-AMINO-N-BUTYRIC ACID L-(+)-2-AMINOBUTYRIC ACID L-ALPHA-AMINO-N-BUTYRIC ACID H-ABU(ALPHA)-OH H-ABU(2)-OH H-2-ABU-OH 2-AMINO-BUTYRIC ACID (S)-(+)-2-AMINO-N-BUTYRIC ACID (S) 2-AMINOBUTYRIC ACID (S)-(+)-2-AMINOBUTYRIC ACID (S)-(+)-2-Aminobutyric acid; (S)-(+)-2-Aminobutyric acid; 2-Aminobutanoic acid;L(+)-2-Aminobutyric acid H-L-NHCH(CH2CH3)-COOH H-L-ABU-OH (S)-(+)-α-aminobutyricacid L-A-AMINO-N-BUTYRIC ACID CELL CULTURETES TED L-A-AMINO-N-BUTYRIC ACID SIGMA GRADECRYS TALLINE (2S)-2-Aminobutanoic Acid (S)-(+)-a-2-Aminobutyric Acid L-a-2-Aminobutyric Acid L-Ethylglycine LH-L-ABU-OH L-(+)-2-Aminobutyric L-2-Abu-OH L-ABU-OH L-2-AMINOBUTYRIC ACID >= 99% (TITRAT L-α-Aminobutyric acid≥ 99% (Titration) L-α-Aminobutyric acid L(+)-2-Aminobutyric acid (S)-(+)-2-Aminobutyric acid 2-Aminobutanoic acid H-Abu-OH (S)-2-aminobutanoicacid (s)-butanoicaci Butanoic acid, 2-amino-, (S)- butanoicacid,2-amino-,(S)-(+)- Butyric acid, 2-amino-, L- L-alpha-Aminobutyrate L-Butyrine L-α-aminobutyricacid S-butyrine H-Abu-OH (L-2-Aminobutyric acid L-a-Amino-butyric acid (S)-(+)-2-Aminobutyric acid) L-(+)-2-Aminobutyric acid, 98+% L-α-Amino-butyric acid, L-2-Aminobutyric acid H-Abu-OH (L-2-Aminobutyric acid: L-a-Amino-butyric acid: (S)-(+)-2-Aminobutyric acid) H-Abu-OH (L-2-Aminobutyric acid: L-a-Amino-butyric ac:: (S)-(+)-2-Aminobutyric acid) H-L-2-Abu-OH L-2-Aminobutyric acid,L-α-Aminobutyric acid 2-Aminobutanoic acid, TECH (2S)-2-Aminobutyric acid, L-2-Aminobutyric acid (S)-2-AMinobutanoic Acid, 97+% L-2-Aminobutyric aCld Butanoic acid, 2-amino-, (2S)- NSC 97060 L(+)-2-AMinobutyric acid, 98% 1GR D-α-aMino-n-butyric acid L-2-AMinobutyric acid, (S)-(+)-2-AMinobutyric acid (2S)-2-Aminobutyric acid, L-Aminobutyric acid L-2-AMinobrtyric acid L-Amino butanoic acid Levetiracetam Impurity I L-2-Abu