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Berberine hydrochloride

Berberine hydrochloride
Berberine hydrochloride structure
CAS No.
633-65-8
Chemical Name:
Berberine hydrochloride
Synonyms
BBR;CI 75160;Kyoberin;NSC 646666;UMBELLATINE;BERBERIN HCL;Benzodioxide;BERBERINE HCL;Berberine chL;Berberdine HCl
CBNumber:
CB3758777
Molecular Formula:
C20H18ClNO4
Formula Weight:
371.81
MOL File:
633-65-8.mol

Berberine hydrochloride Properties

Melting point:
204-206 °C (dec.)
storage temp. 
Inert atmosphere,2-8°C
solubility 
methanol: soluble
form 
Yellow powder
Colour Index 
75160
color 
Yellow powder
Water Solubility 
SOLUBLE IN COLD WATER
BRN 
3836585
InChIKey
VKJGBAJNNALVAV-UHFFFAOYSA-M
CAS DataBase Reference
633-65-8
EPA Substance Registry System
Berberine chloride (633-65-8)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  24/25-36-26
RIDADR  1544
WGK Germany  2
RTECS  DR9866400
3-10
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29349990
Toxicity LD50 orl-rat: >15 g/kg KSRNAM 8,654,74

Berberine hydrochloride price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 200275 Berberine Chloride A highly potent and selective oxysterol EBI2 (GPR183) agonist (K 633-65-8 25mg $32.6 2021-12-16 Buy
Sigma-Aldrich 1065210 Berberine Chloride United States Pharmacopeia (USP) Reference Standard 633-65-8 50mg $536 2021-12-16 Buy
Alfa Aesar J62311 Berberine chloride 633-65-8 5g $37.1 2021-12-16 Buy
Usbiological 003881 Berberine Hydrochloride 633-65-8 25g $389 2021-12-16 Buy
Biorbyt Ltd orb105710 Berberine hydrochloride >98%,Standard References Grade 633-65-8 20 mg $569.5 2021-12-16 Buy

Berberine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

yellow crystalline powder

Uses

antiarrhythmic, alpha2 agonist, anticonvulsant, antiinflammatory, antibacterial, antifungal, antitrypanosomal, antineoplastic, immunostimulant

Uses

An isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme cyclooxygenase-2 (cox-2) which is abundantly expressed in colon cancer cells. Al so inhibits Activator Protein 1 (AP-1), a transcription factor that plays a critical role in inflammation and carcinogenesis. Treatment with berberine potentially results in the reduced accumulation o f chemotherapeutic drugs.

Uses

An ingredient in some commercial eyewash products.

General Description

A highly potent and selective oxysterol EBI2 (GPR183) agonist (Kd) = 450 pM in a saturation binding assay, and EC50 = 140 pM over EC50 = 2.1 nM for its enantiomer, 7β,25-OHC, in a GTP-γS binding assay). Dose-dependently suppresses forskolin-induced cAMP accumulation in an EBI2-expressing SK-N-MC/CRE-β-galactosidase cell line (IC50 = 2 nM), but not in control cells. Stimulates migration of LPS-activated spleen B-cells and anti-CD3/CD28-activated CD4+ T-cells in a dose-dependent manner. In addition, pharmacological inhibition of its biosynthesis in vivo by Clotrimazole, a CYP7B1inhibitor, promotes the migration of adoptively transferred pre-activated B cells to the T/B boundary, mimicking the phenotype of pre-activated B cells in EBI2-deficient mice.

Biochem/physiol Actions

An alkaloid with weak antibiotic properties. Substrate for MDR efflux pumps. Antimicrobial activities of berberine is potentiated by the MDR inhibitor 5′-methoxyhydnocarpin (5′-MHC). Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.

Safety Profile

Poison by intraperitoneal route.Slightly toxic by ingestion. Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx andCl-.

Purification Methods

Berberine chloride crystallises from water to give the dihydrate. The anhydrous salt may be obtained by recrystallisation from EtOH/Et2O, wash the crystals with Et2O and dry them in a vacuum. The iodide has m 250o(dec) (from EtOH). [Perkin J Chem Soc 113 503 1918, Kametani et al. J Chem Soc(C) 2036 1969, Beilstein 27 I 515, 27 II 567.]

Berberine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Berberine hydrochloride Suppliers

Global( 485)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3001 58
Xi'an Kono chem co., Ltd.,
13289246953 029-86107037
info@konochemical.com CHINA 3000 58
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
+8617731987558
xingjiu@xingjiubiotech.com China 1001 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 15424 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9128 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58

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View Lastest Price from Berberine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-19 Berberine hydrochloride
633-65-8
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2022-01-19 Berberine Hydrochloride;Berberine hcl
633-65-8
US $1.00 / g 10g 97% HPLC 1000kg Guangzhou Biocar Biotechnology Co.,Ltd.
2021-12-23 Berberine hydrochloride
633-65-8
US $0.00 / KG 1g 99% 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Berberine hydrochloride Spectrum


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