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Tetraethylammonium Chloride

CAS No.
56-34-8
Chemical Name:
Tetraethylammonium Chloride
Synonyms
teac;Tetraethylammonium;TEA CHLORIDE;ETAMON CHLORIDE;SKL1479;N2,2,2,2Cl;ammonium chL;Ethamon chloride;Tetraethylammonium choride;tetraethyl-ammoniuchloride
CBNumber:
CB4136114
Molecular Formula:
C8H20ClN
Molecular Weight:
165.7
MDL Number:
MFCD00011828
MOL File:
56-34-8.mol
MSDS File:
SDS
Last updated:2024-08-12 17:17:06

Tetraethylammonium Chloride Properties

Melting point 39°C
Boiling point 273.32°C (rough estimate)
Density 1.08
refractive index 1.5480 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility methanol: 0.1 g/mL, clear, colorless
form Crystalline Powder
color white to light yellow
PH 4.0 to 7.0(50g/L, 25℃)
Water Solubility Soluble in water, ethanol, chloroform, or acetone
λmax λ: 260 nm Amax: 0.03
λ: 280 nm Amax: 0.03
Sensitive Hygroscopic
Merck 14,9200
BRN 3563247
Stability Stable. Incompatible with strong oxidizing agents. Protect from moisture.
InChIKey YMBCJWGVCUEGHA-UHFFFAOYSA-M
CAS DataBase Reference 56-34-8(CAS DataBase Reference)
FDA UNII 8B82Z83XNN
EPA Substance Registry System Tetraethylammonium chloride (56-34-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
RTECS  BS6125000
3-10
TSCA  Yes
HS Code  29239000
Toxicity LD50 i.v. in dogs: 55.7-72.4 mg/kg (Keith, Jr.)
NFPA 704
0
2 0

Tetraethylammonium Chloride price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 113042 Tetraethylammonium chloride hydrate 56-34-8 25g $58.8 2024-03-01 Buy
Sigma-Aldrich 113042 Tetraethylammonium chloride hydrate 56-34-8 100g $187 2024-03-01 Buy
TCI Chemical T0095 Tetraethylammonium Chloride >98.0%(T) 56-34-8 25g $47 2024-03-01 Buy
TCI Chemical T0095 Tetraethylammonium Chloride >98.0%(T) 56-34-8 100g $107 2024-03-01 Buy
Alfa Aesar J62507 Tetraethylammonium chloride 56-34-8 25g $31.5 2024-03-01 Buy
Product number Packaging Price Buy
113042 25g $58.8 Buy
113042 100g $187 Buy
T0095 25g $47 Buy
T0095 100g $107 Buy
J62507 25g $31.5 Buy

Tetraethylammonium Chloride Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Uses

Tetraethylammonium chloride (TEAC) has been used:

  • used for inhibition of peroxynitrite induced relaxation in rat aorta rings
  • as a pharmacological blocker of K+ current and Ca2+ induced K+ current in antennal lobe neurons
  • for the induction of TEAC sensitive currents in cochlear inner hair cells digested with proteolytic enzymes and analyze its properties

Uses

Medicine (nerve-blocking agent).

Uses

Tetraethylammonium Chloride can be used as a source of tetraethylammonium ions for various pharmaceutical studies and has the ability to block K+ channels in various tissues. Tetraethylammonium Chloride can also block the transmission of nervous impulses across autonomic ganglions.

Definition

ChEBI: A quarternary ammonium chloride salt in which the cation has four ethyl substituents around the central nitrogen.

General Description

Visit our Sensor Applications portal to learn more.

Biological Activity

Non-selective K + channel blocker.

Biochem/physiol Actions

Tetraethylammonium chloride (TEAC) blocks K+ channels non-specifically. In rat aorta rings, tetraethylammonium inhibits relaxation induced by peroxynitrite. It blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K+ currents. TEAC can increase the contractility and mobility of colon and rectum and is a therapeutic option for Hirschsprung′s disease patients. TEAC reduces the inflammatory responses, improves cardiac, vascular and hemodynamic properties during early sepsis in animals. TEAC has cytotoxic and anti-proliferative potential and induces apoptosis in glioma cells by downregulating B-cell lymphoma-2 (Bcl-2) and upregulating Bcl-2 associated X (Bax).

in vitro

tetraethylammonium (tea) is a small ion that is thought to block open k channels by binding either to an internal or to an external site. for this reason, it has been used to probe the ion conduction pathway or pore of k channel mutants and a k channel chimera. tea blocks k+ channels at two sites, which define the inner and outer mouths of the channel pores [1].

in vivo

vasorelaxant effect of taurine can be diminished by tea in rat isolated arteries [2]

storage

Room temperature (desiccate)

Purification Methods

Crystallise the chloride from EtOH by adding diethyl ether, from warm water by adding EtOH and diethyl ether, from dimethylacetamide or from CH2Cl2 by addition of diethyl ether. Dry it over P2O5 in vacuum for several days. It also crystallises from acetone/CH2Cl2/hexane (2:2:1) [Blau & Espenson J Am Chem Soc 108 1962 1986, White & Murray J Am Chem Soc 109 2576 1987]. [Beilstein 4 IV 332.]

References

[1] taglialatela m, vandongen am, drewe ja, joho rh, brown am, kirsch ge. patterns of internal and external tetraethylammonium block in four homologous k+ channels. mol pharmacol. 1991 aug;40(2):299-307.
[2] niu lg, zhang ms, liu y, xue wx, liu db, zhang j, liang yq. vasorelaxant effect of taurine is diminished by tetraethylammonium in rat isolated arteries. eur j pharmacol. 2008 feb 2;580(1-2):169-74. epub 2007 oct 25.
[3] shea pa, dunklee pe, et al. preliminary clinical investigation of tetraethylammonium chloride with particular reference to disorders of the circulatory system. calif med. 1948 sep;69(3):193-6.

2603-10-3
56-34-8
Synthesis of Tetraethylammonium Chloride from N-PHENYLCARBAMIC ACID METHYL ESTER
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View Lastest Price from Tetraethylammonium Chloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tetraethylammonium Chloride pictures 2024-10-31 Tetraethylammonium Chloride
56-34-8
US $25.00 / kg 1kg 99% 5000kg/week Hebei Zhuanglai Chemical Trading Co.,Ltd
Tetraethylammonium Chloride pictures 2024-10-31 Tetraethylammonium Chloride
56-34-8
US $0.00 / KG 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
Tetraethylammonium Chloride pictures 2024-10-11 Tetraethylammonium Chloride
56-34-8
US $5.00-2.00 / kg 1kg 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
TETRAETHYLAMMONIUM CHLORIDE tetraethyl-ammoniuchloride TETRAETHYLAMMONIUMCHLORIDE,MONOHYDRATE,CRYSTAL,REAGENT AMMONIUM,TETRAETHYL-,CHLORIDE TETRAETHYLAMINEHYDROCHLORIDE TETRAETHYLAMMONIUM CHLORIDE SOLUTION TETRAETHYLAMMONIUM CHLORIDE, FOR MOLECUL AR BIOLOGY TETRAETHYLAMMONIUM CHLORIDE, ELECTRO-CHE MICAL GRADE TETRAETHYLAMMONIUM CHLORIDE NICOTINIC BL OCKING AG Tetraethylammonium choride Tetraethylammonium chloride monohydrate, 99+% Tetraethylammonium chloride ,98% TETRAETHYLAMMONIUM CHLORIDE HYDRATE, 99 % Tetraethylaminium·chloride Tetraethylammonium chloride(TEAC) N,N,N,N-Tetraethylammoniumchloride Tetraethylammonium chloride,TEA chloride Tetraethylammonium chloride puriss., electrochemical grade, >=99.0% (AT) Tetraethylammonium chloride (TEA) tetraethylazaniuM chloride Ethanaminium,N,N,N-triethyl-,chloride n,n,n-triethyl-ethanaminiuchloride n,n,n-triethylethanaminiumchloride TetraethylaMMoniuM chloride hydrate, 99% 100GR TetraethylaMMoniuM chloride hydrate, 99% 25GR tetraethylazaniuM dihydrochloride Manganese chloride TetraethylaMMoniuM chlorid Fourethyl aMMoniuM chloride TEAC)TetraethylaMMoniuM chlo Tetraethylammonium chloride Vetec(TM) reagent grade, 98% N2,2,2,2Cl Ethamon chloride TETRAETHYLAMMONIUM CHLORIDE BIOULTRA Ethanaminium, N,N,N-triethyl-, chloride (1:1) TETRA ETHYL AMMONIUM CHLORIDE TEACL ammonium chL Tetraethylammonium Chloride > Tetraethylammonium chloride, 98%, for synthesis etraethylammonium Chloride SKL1479 ETAMON CHLORIDE TEA CHLORIDE Tetraethylammonium teac Tetraethylammonium Chloride [N2,2,2,2]Cl Tetraethylammonium chloride (6CI, 7CI) 56-34-8 C2H54NCl NC2H54Cl C8H20CIN C8H20ClNxH2O C2H54NClH2O C8H20NCl C8H20ClNH2O Ammonium Salts BioChemical Cell Signaling and Neuroscience Cell Biology