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Abacavir Carboxylate

CAS No.
384380-52-3
Chemical Name:
Abacavir Carboxylate
Synonyms
2269W;Abacavir Impurity 14;Abacavir Carboxylate;(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-ene-1-carboxylic acid;(1S,4R)-4-(2-Amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-enecarboxylic acid;(1S,4R)-4-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]-2-cyclopentene-1-carboxylic Acid;2-Cyclopentene-1-carboxylic acid, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1S,4R)-
CBNumber:
CB42502991
Molecular Formula:
C14H16N6O2
Molecular Weight:
300.32
MDL Number:
MOL File:
384380-52-3.mol
Last updated:2023-05-18 11:31:09

Abacavir Carboxylate Properties

Melting point 208-210°C (dec.)
storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form Solid
color Off-White to Pale Beige
Stability Hygroscopic
FDA UNII FO2D75G53I

Abacavir Carboxylate price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 27777 Abacavir Carboxylate 384380-52-3 1mg $364 2024-03-01 Buy
Usbiological 295337 Abacavir carboxylate 384380-52-3 1mg $633 2021-12-16 Buy
TRC A105005 AbacavirCarboxylate 384380-52-3 10mg $1815 2021-12-16 Buy
Biosynth Carbosynth NA16897 Abacavir carboxylate 384380-52-3 10mg $1950 2021-12-16 Buy
Medical Isotopes, Inc. 18915 AbacavirCarboxylate 384380-52-3 10mg $2700 2021-12-16 Buy
Product number Packaging Price Buy
27777 1mg $364 Buy
295337 1mg $633 Buy
A105005 10mg $1815 Buy
NA16897 10mg $1950 Buy
18915 10mg $2700 Buy

Abacavir Carboxylate Chemical Properties,Uses,Production

Description

Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir . It is formed from abacavir via reactive aldehyde intermediates that can form adducts with proteins on valine residues.

Chemical Properties

Off-White Solid

Uses

Abacavir Carboxylate (Abacavir - In House Impurity) is a major metabolite of Abacavir (A105000) in human urine and cerebrospinal fluid (1,2,3).

Definition

ChEBI: Abacavir 5'-carboxylic acid is a monocarboxylic acid oxidation product of abacavir, in which the C-5' hydroxymethyl group has been oxidised to a carboxy group. One of the two major metabolites of abacavir in humans (the other is the 5'-glucuronide, CHEBI:64189). It has a role as a metabolite. It is functionally related to an abacavir.

Abacavir Carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Shenzhen Regent Biochemical Technology Co., Ltd. 0755-0755-85201366 18938635012 sales@regentsciences.com China 9288 58
Abacavir Carboxylate (1S,4R)-4-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]-2-cyclopentene-1-carboxylic Acid 2269W (1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-ene-1-carboxylic acid (1S,4R)-4-(2-Amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-enecarboxylic acid 2-Cyclopentene-1-carboxylic acid, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1S,4R)- Abacavir Impurity 14 384380-52-3 Metabolites & Impurities, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals Bases & Related Reagents Intermediates & Fine Chemicals Metabolites & Impurities Nucleotides Pharmaceuticals