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L-(+)-Isoleucinol

L-(+)-Isoleucinol structure

CAS No.: 24629-25-2

Chemical Name:: L-(+)-Isoleucinol

Synonyms: L-ISOLEUCINOL;2-amino-3-methylpentan-1-ol;H-ILE-OL;L-Ile-ol;H-L-ILE-OL;H-ISOLEUCINOL;L(+)-ISOLEUCINOL;L-Isoleucinol>(+)-L-ISOLEUCINOL;(S)-(+)-ISOLEUCINOL

CBNumber:: CB4284679

Molecular Formula:: C6H15NO

Molecular Weight:: 117.19

MDL Number:: MFCD00004731

MOL File:: 24629-25-2.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:47

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L-(+)-Isoleucinol Properties

Melting point	36-39 °C(lit.)
alpha	4.5 º (c=1.6, EtOH)
Boiling point	97 °C14 mm Hg(lit.)
Density	0.9490 (rough estimate)
refractive index	n20/D 1.4589(lit.)
Flash point	213 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka	12.88±0.10(Predicted)
form	Viscous Liquid
color	White to light yellow
optical activity	[α]20/D +4.0°, c = 1.6 in ethanol
InChI	InChI=1S/C6H15NO/c1-3-5(2)6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/t5-,6+/m0/s1
InChIKey	VTQHAQXFSHDMHT-NTSWFWBYSA-N
SMILES	C(O)[C@@H](N)[C@@H](C)CC
CAS DataBase Reference	24629-25-2(CAS DataBase Reference)
NIST Chemistry Reference	(S)-(+)-Isoleucinol(24629-25-2)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Hazard Codes

C,Xi,Xn

Risk Statements

34-22-40

Safety Statements

45-36/37/39-26-36-22-24/25

WGK Germany

HazardClass

IRRITANT

HS Code

29221990

NFPA 704

	1
0		0

L-(+)-Isoleucinol price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	190527	(S)-(+)-Isoleucinol 97%	24629-25-2	1g	$22.48	2024-03-01	Buy
Sigma-Aldrich	190527	(S)-(+)-Isoleucinol 97%	24629-25-2	5g	$145	2023-06-20	Buy
TCI Chemical	I0462	L-Isoleucinol >97.0%(GC)(T)	24629-25-2	1g	$51	2024-03-01	Buy
TCI Chemical	I0462	L-Isoleucinol >97.0%(GC)(T)	24629-25-2	5g	$117	2024-03-01	Buy
Alfa Aesar	H60556	L-Isoleucinol, 97%	24629-25-2	5g	$197	2021-12-16	Buy

Product number	Packaging	Price	Buy
190527	1g	$22.48	Buy
190527	5g	$145	Buy
I0462	1g	$51	Buy
I0462	5g	$117	Buy
H60556	5g	$197	Buy

L-(+)-Isoleucinol Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystalline solid or

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

73-32-5

24629-25-2

The general procedure for the synthesis of L-isoleucinol from L-isoleucine is as follows: the synthesis of L-isoleucinol was carried out by reference to the literature method 61 with minor adjustments. Lithium aluminum hydride (7.2 g, 0.19 mol, 2.5 eq.) was suspended in anhydrous tetrahydrofuran (120 mL) under nitrogen protection with continuous stirring. Subsequently, L-isoleucine (10 g, 0.08 mol) was added in batches and the reaction suspension was heated to reflux for 20 hours. Upon completion of the reaction, it was cooled to room temperature, ethyl acetate was added slowly and the reaction mixture was carefully poured into concentrated sodium hydroxide solution. The organic layer was extracted with water and the organic phase was subsequently dried with sodium sulfate. Removal of the solvent under reduced pressure gave 4.5 g of L-isoleucinol as a yellow oil, which could be used in subsequent reactions without further purification. The product was characterized by 1H NMR (400 MHz, CDCl3) with the following chemical shifts: δ 0.75-0.90 (6H, m), 1.01-1.17 (1H, m), 1.22-1.36 (1H, m), 1.37-1.50 (1H, m), 2.48 (2H, br s), 2.50-2.65 (1H, m), 3.19 -3.29 (1H, m), 3.57 (1H, dd, J = 3.27,10.64Hz) ppm.

References

[1] Synthetic Communications, 1996, vol. 26, # 4, p. 703 - 706
[2] Russian Chemical Bulletin, 2008, vol. 57, # 9, p. 1981 - 1988
[3] Helvetica Chimica Acta, 2004, vol. 87, # 1, p. 90 - 105
[4] Journal of Organic Chemistry, 1993, vol. 58, # 13, p. 3568 - 3571
[5] Chemical Communications, 1997, # 12, p. 1087 - 1088

L-(+)-Isoleucinol Preparation Products And Raw materials

Raw materials

L-Isoleucine Lithium Aluminum Hydride Tetrahydrofuran

Preparation Products

L-(+)-Isoleucinol Suppliers

Global( 284)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TCI AMERICA	800-4238616	sales@tciamerica.com	Americas	23653	75
Hebei Chuanghai Biotechnology Co., Ltd	+8617732866630	abby@chuanghaibio.com	China	8773	58
Hebei Mujin Biotechnology Co.,Ltd	+86-13288715578	sales@hbmojin.com	China	12648	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3692	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58

Supplier	Advantage
TCI AMERICA	75
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Mujin Biotechnology Co.,Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58

View Lastest Price from L-(+)-Isoleucinol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-07-07	L-(+)-Isoleucinol 24629-25-2	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mujin Biotechnology Co.,Ltd
2025-06-24	L-(+)-Isoleucinol 24629-25-2	US $0.00-0.00 / KG	1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-04-15	L-isoleucinol 24629-25-2	US $10.00 / kg	1kg	99%	20ton	Hebei Zhuanglai Chemical Trading Co.,Ltd

L-(+)-Isoleucinol
24629-25-2
US $0.00 / KG
99%
Hebei Mujin Biotechnology Co.,Ltd

L-(+)-Isoleucinol
24629-25-2
US $0.00-0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

L-isoleucinol
24629-25-2
US $10.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co.,Ltd

L-(+)-Isoleucinol Spectrum

L-(+)-Isoleucinol(24629-25-2)MS L-(+)-Isoleucinol(24629-25-2)¹HNMR L-(+)-Isoleucinol(24629-25-2)¹³CNMR L-(+)-Isoleucinol(24629-25-2)IR1 L-(+)-Isoleucinol(24629-25-2)Raman

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(2S,3S)-2-AMINO-3-METHYL-PENTAN-1-OL (2S,3S)-2-AMINO-3-METHYL-1-PENTANOL 2-AMINO-3-METHYL-1-PENTANOL (S)-(+)-Isoleucinol,(2S,3S)-2-Amino-3-methyl-1-pentanol, L-Isoleucinol (S)-(+)-Isoleucinol 97% (S)-(-)-2-aMino-3-Methylpentan-1-ol (S)-(+)-Isoleucinol, 95+% L-Isoleucinol,99%e.e. l-2-Amino-3-methyl-1-pentanol (+)-L-ISOLEUCINOL L(+)-ISOLEUCINOL H-ILE-OL H-L-ILE-OL H-ISOLEUCINOL (S)-(+)-2-AMINO-3-METHYL-1-PENTANOL (S)-(+)-ISOLEUCINOL (S,S)-2-AMINO-3-METHYL-1-PENTANOL 1-Pentanol, 2-amino-3-methyl-, [S-(R*,R*)]- L-Ile-ol (S)-(+)-ISOLEUCINOL / L-(+)-2-AMINO-3-METHYL-1-PENTANOL 1-PENTANOL, 2-AMINO-3-METHYL-, (2S,3S)- (2S,3S)-2-Amino-3-methyl-1-pentanol, L-Isoleucinol (2S,3S)-3-Methyl-2-amino-1-pentanol L(+)-Isoleucinol,97% L-Isoleucinol,(2S,3S)-2-Amino-3-methyl-1-pentanol [(2S,3S)-1-hydroxy-3-methylpentan-2-yl]ammonium L-Isoleucinol> L-(+)-Isoleucinol USP/EP/BP L-ISOLEUCINOL 2-amino-3-methylpentan-1-ol (S)-(+)-Isoleucinol 24629-25-2 24629-25-1 C2H5CHCH3CHNH2CH2OH Chiral Building Blocks Amino Alcohols (Chiral) Peptide Synthesis Specialty Synthesis Amino Alcohols Amino Acid Derivatives Pharmaceutical Intermediates Amines blocks Amino Alcohols Isoleucine [Ile, I] Amino Alcohols (Chiral) Chiral Building Blocks Synthetic Organic Chemistry Chiral Compound Amino alcohols