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N-desalkylflurazepam

N-desalkylflurazepam structure

CAS No.: 2886-65-9

Chemical Name:: N-desalkylflurazepam

Synonyms: DESALKYLFLURAZEPAM;NORFLUDIAZEPAM;N-desallkylflurazepam;FlurazepaM Related CoMpound F;cm7116;ro5-3367;sch17514;RO 5-3367;nor-Flurazepam;norflutoprazepam

CBNumber:: CB4316060

Molecular Formula:: C15H10ClFN2O

Molecular Weight:: 288.7

MDL Number:: MFCD00083443

MOL File:: 2886-65-9.mol

Last updated:2024-03-26 14:13:49

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N-desalkylflurazepam Properties

Melting point	204-206°C
Boiling point	454.0±45.0 °C(Predicted)
Density	1.39±0.1 g/cm3(Predicted)
Flash point	9℃
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	A neat solid
pka	11.55±0.70(Predicted)
InChI	InChI=1S/C15H10ClFN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)
InChIKey	UVCOILFBWYKHHB-UHFFFAOYSA-N
SMILES	N1C2=CC=C(Cl)C=C2C(C2=CC=CC=C2F)=NCC1=O
CAS DataBase Reference	2886-65-9(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	X9U41NXR6M
NIST Chemistry Reference	Norfludiazepam(2886-65-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H336

Precautionary statements

P261-P271-P304+P340+P312-P403+P233-P405-P501

Hazard Codes

F,T

Risk Statements

11-23/24/25-39/23/24/25

Safety Statements

22-24/25-45-36/37-16-7

RIDADR

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany

RTECS

DF2370100

HS Code

2933997500

NFPA 704

	0
2		0

N-desalkylflurazepam price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D-915	Desalkylflurazepam solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?	2886-65-9	1mL	$46.6	2024-03-01	Buy
Sigma-Aldrich	BP730	N-Desalkylflurazepam British Pharmacopoeia (BP) Reference Standard	2886-65-9	25MG	$222	2024-03-01	Buy
Sigma-Aldrich	1285603	Flurazepam Related Compound F United States Pharmacopeia (USP) Reference Standard	2886-65-9	50mg	$456	2024-03-01	Buy
Cayman Chemical	18484	Desalkylflurazepam ≥98%	2886-65-9	1mg	$32	2024-03-01	Buy
Cayman Chemical	18484	Desalkylflurazepam ≥98%	2886-65-9	5mg	$145	2024-03-01	Buy

Product number	Packaging	Price	Buy
D-915	1mL	$46.6	Buy
BP730	25MG	$222	Buy
1285603	50mg	$456	Buy
18484	1mg	$32	Buy
18484	5mg	$145	Buy

N-desalkylflurazepam Chemical Properties,Uses,Production

Description

Desalkylflurazepam (Item No. 18484) is an analytical reference material that is structurally categorized as a benzodiazepine. It is an active metabolite of several benzodiazepines, including flurazepam , flutoprazepam, fludiazepam, midazolam, and quazepam. Desalkylflurazepam inhibits L-type voltage-gated calcium channels (Ca_v; IC₅₀s = 55 and 37 μM for Ca_v1.2 and 1.3, respectively) by positively modulating GABA_A receptors. It can be detected in urine, serum, and meconium by LC-MS/MS. This product is intended for research and forensic applications.

Chemical Properties

Light Yellow Solid

Uses

The major human metabolite of flurazepam. This is a controlled drug precursor therefore a liscence may be required for purchase

Definition

ChEBI: Desalkylflurazepam is a benzodiazepine.

General Description

N-Desalkylflurazepam (also known as norflurazepam, 2886-65-9) is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward.

Mode of action

N-Desalkylflurazepam is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward.

N-desalkylflurazepam synthesis

Synthesis of N-desalkylflurazepam from 2-chloro-N-[4-chloro-2-(2-fluorobenzoyl)phenyl]acetamide

N-desalkylflurazepam Preparation Products And Raw materials

Raw materials

7-Chloro-1,3-dihydro-5-(2-fluorophenyl)-2-nitromethyl-ene-2H-1,4-benzodiazepine 2-bromo-4'-chloro-2'-(o-fluorobenzoyl)acetanilide 2-chloro-N-[4-chloro-2-(2-fluorobenzoyl)phenyl]acetamide BOC-Glycine

Preparation Products

Flualprazolam 2-Amino-5-chloro-2'-fluorobenzophenone 4-Imidazolidinone, 1,1'-methylenebis[3-[4-chloro-2-(o-fluorobenzoyl)phenyl]- (7CI,8CI) Midazolam [7-CHLORO-5-(2-FLUORO-PHENYL)-3H-BENZO[E][1,4]DIAZEPIN-2-YL]-METHYL-AMINE

N-desalkylflurazepam Suppliers

Global( 204)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	kathy@hbyinsheng.com	China	3582	58
Dorne Chemical Technology co. LTD	+86-13583358881 +86-18560316533	Ethan@dornechem.com	China	294	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Anhui Yiao New Material Technology Co., Ltd	+86-199-55145978 +8619955145978	sales8@anhuiyiao.com	China	253	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Shandong Hanjiang Chemical Co., Ltd	+86-0533-2066820 +8618369939125	hanson@sdhanjiang.com	China	1527	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58

Supplier	Advantage
Hebei Miaoyin Technology Co.,Ltd	58
Dorne Chemical Technology co. LTD	58
Hebei Mojin Biotechnology Co., Ltd	58
Anhui Yiao New Material Technology Co., Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Shandong Hanjiang Chemical Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58

View Lastest Price from N-desalkylflurazepam manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-26	NORFLUDIAZEPAM 2886-65-9	US $10.00 / ASSAYS	1ASSAYS	99%	100kg	Dorne Chemical Technology co. LTD
2024-04-12	N-desalkylflurazepam 2886-65-9	US $0.00 / kg	1kg	0.99	10T	Shandong Hanjiang Chemical Co., Ltd
2024-01-08	7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one 2886-65-9	US $36.00-25.00 / kg	1kg	99.60%	50tons	Wuhan Boyuan Import & Export Co., LTD

NORFLUDIAZEPAM
2886-65-9
US $10.00 / ASSAYS
99%
Dorne Chemical Technology co. LTD

N-desalkylflurazepam
2886-65-9
US $0.00 / kg
0.99
Shandong Hanjiang Chemical Co., Ltd

7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
2886-65-9
US $36.00-25.00 / kg
99.60%
Wuhan Boyuan Import & Export Co., LTD

N-desalkylflurazepam Spectrum

N-desalkylflurazepam(2886-65-9)¹HNMR

2886-65-9(N-desalkylflurazepam)Related Search:

CHLOROPHENYLSILANE 97 Hydrochlorothiazide tert-Butylchlorodiphenylsilane Epichlorohydrin PHENYL VALERATE

Chlorodimethylphenylsilane DBU Triphenylmethyl Chloride Phenylhydrazine Dihydromyrcenol

7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one FLURAZEPAM DIHYDROCHLORIDE Doxefazepam Elfazepam Chloroacetic acid

Proflazepam Difluorochloromethane Fludiazepam

1of4

Dealkylflurazepam Descarbethoxyloflazepate Flurazepam M (des-alkyl) Flurazepam M (N-1-des-alkyl) Flurazepam, des-alkyl N-1-desalkyl-flurazepam N-Desalkyl-2-oxoquazepam N-Desalkylflurazepam N-Desalkylflutoprazepam norflutoprazepam RO 5-3367 1,3-dihydro-7-chloro-5-(2-fluorophenyl)-2h-4-benzodiazepin-2-one 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-fluorophenyl)- 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro- 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-fluorophenyl)-1,3-dihydro- 7-chloro-5-(o-fluorophenyl)-1,3-dihydro-2h-4-benzodiazepin-2-one ro5-3367 sch17514 7-CHLORO-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE 7-CHLORO-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-1,4-BENZODIAZEPIN-2-ONE 7-CHLORO-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE 5-(2-FLUOROPHENYL)-7-CHLORO-1,4-BENZODIAZEPIN-2-ONE cm7116 DESALKYLFLURAZEPAM,100/MLINMETHANOL nor-Flurazepam Flurazepam Related Compound F (50 mg) (7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one) 7-Chloro-5-(2-fluorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one 7-chloro-5-(2-fluorophenyl)- 1,4-Benzodiazepin-2-one desalkylflurazepam Solution, 100ppm Desalkylflurazepam solution 7-CHLORO-5-(2-FLUOROPHENYL)-1,3-DIHYDROXY-4-BENZODIAZEPIN-2-ONE 5-(2-Fluorophenyl)-1,3-dihydro-7-chloro-2H-1,4-benzodiazepin-2-one DESALKYLFLURAZEPAM,1.0MG/MLINMETHANOL 7-CHLORO-5-(2-FLUOROPHENYL)-1,3- DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE 98.0% MIN 2H-1,4-BENZODIAZEIN-2-ONE-7-CHLORO-5-(2-FLUOROPHENYL)-1,3-DIHYDRO 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one 5-(2-Fluorophenyl)-1,3-dihydro-7-chloro-2H-1,4-benzodiazepin-2-oneNorfludiazepam 5-(2-Fluorophenyl)-7-chloro-1,3-dihydro-3H-1,4-benzodiazepin-2-one Flurazepam Related Compound F Solution, 100ppm Midazolam Impurity F Desalkylflurazepam (CRM) Midazolam Impurity 6(Midazolam EP Impurity F) Midazolam ImpurityⅠ:7-Chloro-5-(2-fluoro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one Flurazepam Hydrochloride ImpurityⅠ：7-Chloro-5-(2-fluoro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one nor-Flurazepam (1.0 mg/mL in Methanol) Flurazepam Related Compound F(Secondary Standards traceble to USP) TIANFU CHEM 7-Chloro-5-(2-fluoro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one Flurazepam Hydrochloride ImpurityⅠ：7-Chloro-5-(2-fluoro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one Midazolam ImpurityⅠ:7-Chloro-5-(2-fluoro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one Flurazepam Related Compound F (7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one) (1285603) 7-Chloro-5-(2-fluoropheny)-1,3-dihydro-2H-1,4-benzodiazepin-2-one NORFLUDIAZEPAM DESALKYLFLURAZEPAM FlurazepaM Related CoMpound F N-desallkylflurazepam Flurazepam USP Related Compound F N-Desalkylflurazepam, Norflurazepam Flurazepam-N-desalkyl