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FLURAZEPAM DIHYDROCHLORIDE

FLURAZEPAM DIHYDROCHLORIDE Structure
FLURAZEPAM DIHYDROCHLORIDE structure
CAS No.
1172-18-5
Chemical Name:
FLURAZEPAM DIHYDROCHLORIDE
Synonyms
id480;somlan;Felson;lunipax;insumin;benozil;dalmane;dalmate;felison;Durapam
CBNumber:
CB8774008
Molecular Formula:
C21H25Cl3FN3O
Molecular Weight:
460.8
MDL Number:
MFCD00058189
MOL File:
1172-18-5.mol
Last updated:2023-05-04 17:34:32
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FLURAZEPAM DIHYDROCHLORIDE Properties

Melting point 190-220°
storage temp. 2-8°C
solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <6 mg/mL
form solid
color light yellow
CAS DataBase Reference 1172-18-5(CAS DataBase Reference)
FDA UNII 756RDM536M
Proposition 65 List Flurazepam Hydrochloride
EPA Substance Registry System Flurazepam dihydrochloride (1172-18-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H373
Precautionary statements  P260-P301+P312+P330
Hazard Codes  Xn,T,F
Risk Statements  22-33-39/23/24/25-23/24/25-11
Safety Statements  1/2-22-36-36/37/39-45-36/37-16-7
RIDADR  3249
WGK Germany  3
RTECS  DF0875000
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933910000
Toxicity LD50 in mice (mg/kg): 290 i.p.; 870 orally; 84 i.v. (Randall)

FLURAZEPAM DIHYDROCHLORIDE price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1285002 Flurazepam hydrochloride United States Pharmacopeia (USP) Reference Standard 1172-18-5 200mg $647 2024-03-01 Buy
American Custom Chemicals Corporation API0002742 FLURAZEPAM DIHYDROCHLORIDE 95.00% 1172-18-5 5MG $786.5 2021-12-16 Buy
American Custom Chemicals Corporation API0002742 FLURAZEPAM DIHYDROCHLORIDE 95.00% 1172-18-5 50MG $1963.5 2021-12-16 Buy
AHH MT-51861 Flurazepamdihydrochloride 98% 1172-18-5 0.5g $280 2021-12-16 Buy
Product number Packaging Price Buy
1285002 200mg $647 Buy
API0002742 5MG $786.5 Buy
API0002742 50MG $1963.5 Buy
MT-51861 0.5g $280 Buy

FLURAZEPAM DIHYDROCHLORIDE Chemical Properties,Uses,Production

Originator

Dalmane, Roche,US,1970

Uses

Flurazepam is used as an sedative, hypnotic. This is a controlled substance (depressant).

Definition

ChEBI: Flurazepam hydrochloride is a benzodiazepine.

Manufacturing Process

13 grams of 5-(2-fluorophenyl)-7-chloro-2,3-dihydro-1H-1,4benzodiazepinone-(2) were dissolved in 100 ml of N,N-dimethylformamide andtreated with 10.3 ml of a solution of sodium methoxide in methanol containing 54 mmol or 2.95 grams of sodium methoxide. The resulting solution was stirred at about 20°C for 1 hour and then cooled in an ice-salt mixture to 0°C. A solution of diethylamino-ethyl chloride was prepared by dissolving 13.8 grams of diethylamino-ethyl chloride hydrochloride in cold dilute sodium hydroxide solution and extracting the base four times with 50 ml of toluene each time. The toluene extracts were combined, dried over anhydrous sodium sulfate, filtered and added to the reaction mixture.
The mixture was allowed to stand for 70 hours and then concentrated to a small volume under reduced pressure. The residue was dissolved in 100 ml of methylene chloride, washed with 75 ml of water, three times with 50 ml of saturated brine solution each time and filtered over neutral alumina (grade 1). The filtrate was evaporated to dryness and the resulting colorless oil taken up in ether, which was then saturated with hydrogen chloride. The pale yellow precipitate was filtered off and recrystallized from methanol/ether yielding 1[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-7-chloro-2,3-dihydro-1H-1,4benzodiazepinone-(2) dihydrochloride as pale yellow rods melting at 190° to 220°C with decomposition, (from British Patent 1,040,548).

Therapeutic Function

Hypnotic

General Description

Odorless off-white to yellow crystalline powder.

General Description

Flurazepamhydrochloride, 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1, 3-dihydro-2H-1, 4-benzodiazepine-2-onedihydrochloride (Dalmane), is notable as a benzodiazepinemarketed almost exclusively for use in insomnia.Metabolism of the dialkylaminoalkyl side chain isextensive. A major metabolite is N1-dealkyl flurazepam,which has a very long half-life and persists for severaldays after administration. Consequently, it produces cumulativeclinical effects and side effects (e.g., excessivesedation) and residual pharmacologic activity, even afterdiscontinuation.

Air & Water Reactions

Water soluble.

Fire Hazard

Flash point data for FLURAZEPAM DIHYDROCHLORIDE are not available. FLURAZEPAM DIHYDROCHLORIDE is probably combustible.

FLURAZEPAM DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

(2-CHLORO-ETHYL)-DIETHYL-AMINE Sodium Methoxide

Preparation Products

FLURAZEPAM DIHYDROCHLORIDE Suppliers

Global( 43)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29220 58
Alfa Chemistry 		+1-5166625404 Info@alfa-chemistry.com United States 21317 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 49999 58
Mainchem Co., Ltd. +86-0592-6210733 sale@mainchem.com China 32360 55
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15421 60
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12338 58
Nanjing Sunlida Biological Technology Co., Ltd. 025-57798810 sales@sunlidabio.com China 3750 55
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2784 58
Raw material medicin reagent co.,Ltd 025-57798860 sales@njromanme.com China 4534 58
Supplier Advantage
career henan chemical co 		58
Dideu Industries Group Limited 		58
Alfa Chemistry 		58
GIHI CHEMICALS CO.,LIMITED 		58
Mainchem Co., Ltd. 55
Chemsky (shanghai) International Co.,Ltd 60
Beijing HuaMeiHuLiBiological Chemical 58
Nanjing Sunlida Biological Technology Co., Ltd. 55
AdooQ BioScience, LLC 58
Raw material medicin reagent co.,Ltd 58

View Lastest Price from FLURAZEPAM DIHYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
FLURAZEPAM DIHYDROCHLORIDE USP/EP/BP pictures 2021-07-29 FLURAZEPAM DIHYDROCHLORIDE USP/EP/BP
1172-18-5
 US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
FLURAZEPAM DIHYDROCHLORIDE pictures 2020-01-13 FLURAZEPAM DIHYDROCHLORIDE
1172-18-5
 US $1.00 / g 1g 99% 200kg Career Henan Chemical Co

1172-18-5(FLURAZEPAM DIHYDROCHLORIDE)Related Search:

Benzophenone imine FLURAZEPAM DIHYDROCHLORIDE FLURAZEPAM 1,2-ETHANEDIAMINE, N-ETHYL-N',N'-DIMETHYL-N-PHENYL- Nordazepam
Fludiazepam Diazapam 1,3-Dihydro-5-phenyl-1,4-benzodiazepin-2-one N-desalkylflurazepam 4-CHLORO-O-TOLUIDINE HYDROCHLORIDE
MEDAZEPAM 1-METHYL-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE CHEMBRDG-BB 5668895 N-(4-CHLOROPHENYL)-N-ETHYLFORMAMIDE 4-CHLORO-N-METHYLFORMANILIDE
BENZHYDRYLIDENE METHYLAMINE 2-FLUORODIPHENYLMETHANE didesethylflurazepam

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1,3-dihydro-l)dihydrochloride id480 id480dihydrochloride insumin lunipax nsc-78559 ro5-6901 somlan Flurazepam Monhydrochloride 2h-1,4-benzodiazepin-2-one,7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluoropheny benozil dalmadorm dalmadormhydrochloride dalmane dalmate dormodor felison FLURAZEPAM DIHCL FLURAZEPAM DIHYDROCHLORIDE FLURAZEPAM HCL FLURAZEPAM HYDROCHLORIDE flurazepam dihydrochloride--dea*schedule iv item FLURAZEPAM DIHYDROCHLORIDE*METHANOL SOLU TION FLURAZEPAM DIHYDROCHLORIDE BENZODIAZEPIN E ANXIOL Durapam 7-CHLORO-1-(DIETHYLAMINO)ETHYL-5-(2-FLUOROPHENYL)-3H-1,4-BENZODIAZEPIN-2(1H)-ONE DIHYDROCHLORIDE 2H-1,4-Benzodiazepin-2-one, 7-chloro-1-[2-(diethylamino) ethyl]-5-(2-fluorophenyl)-1,3-dihydro-, dihydrochloride Ro-5-69 Flurazepam dihydrochloride,7-Chloro-1-(diethylamino)ethyl-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2(1H)-one dihydrochloride Flurazepam Hydrochloride CIV (200 mg)J0C3650.996mg/mg(ai) Flurazepam Hydrochloride CIV (200 mg) 7-Chloro-1-(2-diethylaMinoethyl)-5-(2-fluorophenyl) -1,3-dihydro-2H-1,4-benzodiazepin-2-one Dihydrochloride 7-Chloro-1-[2-(diethylaMino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one Hydrochloride 7-Chloro-1-[2-(diethylaMino)ethyl]-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one Dihydrochloride Felson ZIIJJOPLRSCQNX-UHFFFAOYSA-N Flurazepam Dihydrochloride (1.0mg/ml in Acetonitrile) Flurazepamhydrochlorid FLURAZEPAM DIHYDROCHLORIDE USP/EP/BP Flurazepam HydrochlorideQ: What is Flurazepam Hydrochloride Q: What is the CAS Number of Flurazepam Hydrochloride Q: What is the storage condition of Flurazepam Hydrochloride 1172-18-5 172-18-5 C21H23ClFN3O2HCl C21H23ClFN3O2ClH Organics