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Oxendolone

Oxendolone
Oxendolone structure
CAS No.
33765-68-3
Chemical Name:
Oxendolone
Synonyms
TSAA 291;Prostetin;Oxendolone;ESTR-4-EN-3-ONE;Oxendolone USP/EP/BP;16b-Ethyl-19-nortestosterone;16β-Ethyl-19-nortestosterone;16beta-Ethyl-19-nortestosterone;16β-Ethyl-17β-hydroxyestr-4-en-3-one;16b-Ethyl-17b-hydroxyestr-4-en-3-one
CBNumber:
CB4969631
Molecular Formula:
C20H30O2
Formula Weight:
302.45
MOL File:
33765-68-3.mol

Oxendolone Properties

Melting point:
152-153℃
alpha 
D +41° (c = 1.0 in ethanol)
Boiling point:
383.47°C (rough estimate)
Density 
1.0434 (rough estimate)
refractive index 
1.4980 (estimate)
FDA UNII
MN4I850D4P
SAFETY
  • Risk and Safety Statements
Toxicity LD50 in rats, mice (g/kg): >10 orally; 5-10 i.m. and i.p. (Hiraga, 1971)

Oxendolone Chemical Properties,Uses,Production

Originator

Prostetin,Takeda, Japan ,1981

Uses

Anti-androgen (benign prostatic hypertrophy).

Manufacturing Process

To a solution of 3.0 g of 16β-ethylestra-4-ene-3,17-dione dissolved in 150 ml of dioxane, are added 15 g of ethyl orthoformate and 0.1 g of ptoluenesulfonic acid, followed by stirring for 2 hours at room temperature. The reaction solution is poured into 300 ml of a 5% aqueous solution of sodium hydrogen carbonate and the resultant mixture is extracted with ether. The ether layer is washed with water and dried, followed by evaporation of the solvent to give crude crystals of 3-ethoxy-16β-ethylestra-3,5-diene-17-one. The crystals are recrystallized from ether to give 3.0 g of the compound melting at 114°C to 115°C
To a solution of 3.0 g of the enol-ether compound obtained above in 50 ml of methanol, is added 1.5 g of sodium borohydride. After standing for 1.5 hours at room temperature, the reaction solution is poured into 300 ml of water. The resulting precipitates are collected by filtration and recrystallized from ether to give 2.8 g of 3-ethoxy-16β-ethylestra-3,5-dien-17β-ol melting at 131°C to 133°C.
To a solution of 2.5 g of 3-ethoxy-16β-ethylestra-3,5-diene-17β-ol dissolved in 50 ml of methanol is added 1.2 ml of concentrated hydrochloric acid, followed by stirring for 10 minutes. The reaction solution is poured into 250 ml of water. The precipitated crystals are collected by filtration and recrystallized from ether to give 2.3 g of 16β-ethyl-17β-hydroxyestra-4-en-one melting at 152°C to 153°C.

Therapeutic Function

Antiandrogen

Oxendolone Preparation Products And Raw materials

Raw materials

Preparation Products


Oxendolone Suppliers

Global( 8)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd
18192503167 +86-29-89586680
+86-29-88380327 1005@dideu.com CHINA 9937 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 29991 58

View Lastest Price from Oxendolone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-06-08 Oxendolone USP/EP/BP
33765-68-3
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited

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