Boc-L-beta-Homoproline
- CAS No.
- 56502-01-3
- Chemical Name:
- Boc-L-beta-Homoproline
- Synonyms
- (S)-2-(1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)acetic acid;Boc-b-HoPro-OH;Boc-β-HoPro-OH;Boc-p-HomoPro-OH;Boc-β-HomoPro-OH;BOC-BETA-HPRO-OH;BOC-BETA-HOPRO-OH;BOC-BETA3-HOMOPRO;BOC-PRO-(C*CH2)OH;boc-β3-homopro-oh
- CBNumber:
- CB5169171
- Molecular Formula:
- C11H19NO4
- Molecular Weight:
- 229.27
- MDL Number:
- MFCD01862939
- MOL File:
- 56502-01-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 98 °C |
|---|---|
| Boiling point | 357.4±15.0 °C(Predicted) |
| Density | 1.151±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 4.56±0.10(Predicted) |
| form | Crystalline Powder |
| color | White to off-white |
| BRN | 478306 |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-6-4-5-8(12)7-9(13)14/h8H,4-7H2,1-3H3,(H,13,14)/t8-/m0/s1 |
| InChIKey | GDWKIRLZWQQMIE-QMMMGPOBSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC[C@H]1CC(O)=O |
| CAS DataBase Reference | 56502-01-3(CAS DataBase Reference) |
| UNSPSC Code | 12352202 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H319-H315 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Boc-L-beta-Homoproline price More Price(85)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 14982 | Boc-β3-Homopro-OH ≥98.0% (TLC) | 56502-01-3 | 1g | $85 | 2023-06-20 | Buy |
| Usbiological | 261914 | N-Boc-L-b-homoproline | 56502-01-3 | 500mg | $375 | 2026-06-03 | Buy |
| Usbiological | 261914 | N-Boc-L-b-homoproline | 56502-01-3 | 1g | $535 | 2026-06-03 | Buy |
| Usbiological | 261914 | N-Boc-L-b-homoproline | 56502-01-3 | 2g | $716 | 2026-06-03 | Buy |
| Usbiological | 261914 | N-Boc-L-b-homoproline | 56502-01-3 | 5g | $1027 | 2026-06-03 | Buy |
Boc-L-beta-Homoproline Chemical Properties, Uses, Production
Uses
Building block for necine alkaloids.
Uses
Boc-L-beta-homoproline is an amino acid derivative which is a reagent in the synthesis of dihydroisoxazole inhbitors of human transglutaminase 2, an enzyme that catalyzes the modification of glutamine residues. This enzyme has been implicated in numerous inflmmatory, fibrotic and other diseases.
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
88790-37-8
56502-01-3
General procedure for the synthesis of (S)-2-(2-pyrrolidinyl)acetic acid from methyl (S)-2-(2-pyrrolidinyl)acetate: tert-butyl (2S)-2-(2-methoxy-2-oxoethyl)-1-pyrrolidinecarboxylate (8.35 g, 34.3 mmol) was dissolved in 150 mL of methanol. 50 mL of 1 M aqueous sodium hydroxide solution was added and the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solution was concentrated under reduced pressure to about 100 mL. The concentrated solution was added to 300 mL of water and extracted twice with ether (2 x 100 mL). The aqueous phase was acidified to pH 2 with 12N hydrochloric acid and extracted with ether twice more (2 x 100 mL). The aqueous layer was saturated with saturated sodium chloride solution and then extracted with ether a third time (100 mL). All organic layers were combined, washed sequentially with water and saturated sodium chloride solution, and then dried with anhydrous magnesium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to afford the title compound (S)-2-(1-tert-butoxycarbonyl-2-pyrrolidinyl)acetic acid as a white solid (7.28 g, 31.7 mmol, 92.6% yield). peaks, 4H), 1.48 (single peak, 9H) ppm.
References
[1] Patent: WO2003/76440, 2003, A1. Location in patent: Page/Page column 140
[2] Journal of Organic Chemistry, 2005, vol. 70, # 22, p. 8730 - 8733
[3] Organic and Biomolecular Chemistry, 2003, vol. 1, # 22, p. 3977 - 3988
[4] Tetrahedron Letters, 1997, vol. 38, # 20, p. 3609 - 3610
Boc-L-beta-Homoproline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SINO High Goal Chemical Technology Co., Ltd. | 021-57646680 18306277365 | sunkai@chembiobanksh.com | China | 2039 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Shanghai HC Biotech Co., Ltd | 021-20227858 | sale@hcbiotech.com.cn | China | 1173 | 55 |
| ITIC MEDCHEM(SUZHOU) CO.,LTD. | 0512-68323967 18015559028 | sales@iticmedchem.com | China | 528 | 61 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| ForeChem (Nantong) Technology Co.,Ltd. | 513-85982855 18921614129 | sales@xianxingpharm.com | China | 2712 | 61 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44852 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Latest Price from Boc-L-beta-Homoproline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | Boc-L-beta-Homoproline
56502-01-3
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
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2019-07-06 | Boc-L-beta-Homoproline
56502-01-3
|
$1.00 | 1kg | 98% | 100KG | Career Henan Chemical Co |
-
- Boc-L-beta-Homoproline
56502-01-3
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Boc-L-beta-Homoproline
56502-01-3
- $1.00
- 98%
- Career Henan Chemical Co
