ChemicalBook >> CAS DataBase List >>Fostamatinib
Fostamatinib
- CAS No.
- 901119-35-5
- Chemical Name:
- Fostamatinib
- Synonyms
- R788;RT788;CS-883;R7935788;R-935788;R788 5MG;NSC-745942;Tavalisse);Fostatinib;R788, >=99%
- CBNumber:
- CB52499223
- Molecular Formula:
- C23H26FN6O9P
- Molecular Weight:
- 580.46
- MDL Number:
- MFCD16628163
- MOL File:
- 901119-35-5.mol
Last updated:2023-12-26 14:34:07
| Melting point | 214° - 217°C |
|---|---|
| Boiling point | 814.2±75.0 °C(Predicted) |
| Density | 1.496 |
| storage temp. | -20°C, Hygroscopic |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 1.70±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| NCI Dictionary of Cancer Terms | fostamatinib disodium |
| FDA UNII | SQ8A3S5101 |
| NCI Drug Dictionary | fostamatinib disodium |
| ATC code | B02BX09 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
Fostamatinib price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 474099 | Fostamatinib | 901119-35-5 | 100mg | $1423 | 2021-12-16 | Buy |
| Matrix Scientific | 125210 | Fostamatinib 95+% | 901119-35-5 | 1g | $3036 | 2021-12-16 | Buy |
| ChemScene | CS-2152 | Fostamatinib 99.20% | 901119-35-5 | 100mg | $708 | 2021-12-16 | Buy |
| ApexBio Technology | B2284 | Fostamatinib(R788) | 901119-35-5 | 100mg | $713 | 2021-12-16 | Buy |
| AK Scientific | X2110 | Fostamatinibdisodium | 901119-35-5 | 1g | $4148 | 2021-12-16 | Buy |
Fostamatinib Chemical Properties,Uses,Production
Uses
Fostamatinib can be used to treat cancers that have acquired resistance to kinase inhibitors.
Biological Activity
fostamatinib is a small molecule inhibitor of spleen tyrosine kinase (syk) with ic50 value of 41nm [1].fostamatinib is an orally bioavailable prodrug of r406. it is developed for the treatment of autoimmune diseases. the effective metabolite of fostamatinib, r406, is an atp-competitive inhibitor of syk with ki value of 30nm. r406 also inhibits the activity of other kinases including flt3, lyn (ic50=63nm) and lck (ic50=37nm). it is found that r406 inhibits both bcr and fcr mediated responses in vitro. besides that, r406 also shows effects in other cells types and signalling pathways. in the in vivo assay, fostamatinib shows to be highly active to inhibit fcr-mediated signaling in various animal models of allergy, autoimmunity and inflammation. moreover, fostamatinib also exerts efficacy in sle animal models. treatment of fostamatinib suppresses the established renal and skin disease and reduces lymphadenopathy in the mrl/lpr strain [1].
References
[1] mcadoo s p, tam f w k. fostamatinib disodium. drugs of the future, 2011, 36(4): 273.
Synthesis of Fostamatinib from Ditert-butyl [6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxo-pyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate
Fostamatinib Preparation Products And Raw materials
Global( 172)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 | sales@tianpharm.com | CHINA | 304 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29067 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9651 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 +86-13986145403 | info@fortunachem.com | China | 5989 | 58 |
Related articles
- The synthesis method of Fostamatinib
- Fostamatinib is an inhibitor of spleen tyrosine kinase (SYK), a key regulator of signal transduction pathways involved in vari....
- Dec 26，2023
View Lastest Price from Fostamatinib manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-10-09 | Fostamatinib
901119-35-5
|
US $0.00 / kg | 1kg | 0.99 | 20tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2021-10-16 | Fostamatinib
901119-35-5
|
US $0.00 / g | 1g | 98%min | 1000g | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2021-07-13 | Fostamatinib
901119-35-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Fostamatinib
901119-35-5
- US $0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- Fostamatinib
901119-35-5
- US $0.00 / g
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Fostamatinib
901119-35-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
901119-35-5(Fostamatinib)Related Search:
Fostamatinib
FostaMatinib DisodiuM
FostaMatinib (R788)
R788
NSC-745942
R-935788
R7935788
6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one
(6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-3-oxo-2,3-dihydropyrido[3,2-b][1,4]oxazin-4-yl)methyl dihydrogen phosphate
R788, >=99%
FOSTAMATINIB (R788);R788
R788 5MG
Tavalisse)
{[6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]py
rimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2H,3H,4H-
pyrido[3,2-b][1,4]oxazin-4-yl]methoxy}phosphonic
acid
sodium (6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl)methyl phosphate
Fostamatinib USP/EP/BP
2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-
R788 free base
R788 (Fostamatinib, FosD, tamatinib fosdium)
CS-883
R 788;R-788;R788
[6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate
RT788
Blessing him
Fostatinib
13C,2H3]-Fostamatinib
901119-35-5
C23H26FN6O9P
Inhibitors
API