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NSC5844

NSC5844 structure

CAS No.: 140926-75-6

Chemical Name:: NSC5844

Synonyms: RE640;RE 640;RE-640;NSC5844;NSC5844 (RE640);NSC 5844; NSC-5844; RE 640; RE-640; RE640;N,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine;1,2-Ethanediamine, N1,N2-bis(7-chloro-4-quinolinyl)-;NSC 5844,RE640,NSC5844,inhibit,Inhibitor,RE 640,Parasite,NSC-5844

CBNumber:: CB53121123

Molecular Formula:: C20H16Cl2N4

Molecular Weight:: 383.27

MDL Number:: MFCD29924743

MOL File:: 140926-75-6.mol

Last updated:2023-05-21 10:59:17

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NSC5844 Properties

Boiling point	632.6±55.0 °C(Predicted)
Density	1.431±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 0.33 mg/ml; DMSO: 0.25 mg/ml; Ethanol: slightly soluble
form	A crystalline solid
pka	6.61±0.50(Predicted)

NSC5844 price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	23443	NSC 5844 ≥95%	140926-75-6	5mg	$81	2024-03-01	Buy
Cayman Chemical	23443	NSC 5844 ≥95%	140926-75-6	10mg	$152	2024-03-01	Buy
Cayman Chemical	23443	NSC 5844 ≥95%	140926-75-6	25mg	$336	2024-03-01	Buy
Cayman Chemical	23443	NSC 5844 ≥95%	140926-75-6	50mg	$593	2024-03-01	Buy
TRC	B425860	N1,N2-Bis(7-chloroquinolin-4-yl)ethane-1,2-diamine	140926-75-6	10mg	$125	2021-12-16	Buy

Product number	Packaging	Price	Buy
23443	5mg	$81	Buy
23443	10mg	$152	Buy
23443	25mg	$336	Buy
23443	50mg	$593	Buy
B425860	10mg	$125	Buy

NSC5844 Chemical Properties,Uses,Production

Description

NSC 5844 is a bis-quinoline with diverse biological activities. It inhibits the growth of P. falciparum strains that are sensitive (D-6) and resistant (W-2) to chloroquine in vitro (IC₅₀s = 17 and 27 nM, respectively) but lacks activity against P. berghei in vivo. NSC 5844 inhibits the growth of MDA-MB-468 and MCF-7 breast cancer cells with GI₅₀ values of 7.35 and 14.80 μM, respectively. It also inhibits 24% of botulinum neurotoxin serotype A light chain (BoNT/A LC) metalloprotease activity at a concentration of 20 μM.

Uses

N1,N2-Bis(7-chloroquinolin-4-yl)ethane-1,2-diamine and other bisquinoline derivatives have potentials against chloroquine-resistant malaria. A useful intermediate for the preparation of other antimalarial bisaminoquinlines.

NSC5844 Preparation Products And Raw materials

Raw materials

Preparation Products

NSC5844 Suppliers

Global( 69)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	18222	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4664	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2995	58
Grader reagent	18221735425	sales@xinpingchem.com	China	9951	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
InvivoChem	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Aladdin Scientific	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Amadis Chemical Company Limited	58
Shanghai Rechem science Co., Ltd.	58
Grader reagent	58

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NSC5844 N,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine 1,2-Ethanediamine, N1,N2-bis(7-chloro-4-quinolinyl)- RE-640 RE640 RE 640 NSC 5844; NSC-5844; RE 640; RE-640; RE640 NSC5844 (RE640) NSC 5844,RE640,NSC5844,inhibit,Inhibitor,RE 640,Parasite,NSC-5844 140926-75-6