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(R)-N-Boc-glutamic acid-1,5-dimethyl ester

CAS No.
59279-60-6
Chemical Name:
(R)-N-Boc-glutamic acid-1,5-dimethyl ester
Synonyms
N-Boc-L-Glutamic acid dimethyl ester;BOC-GLU(OME)-OME;BOC-L-GLU(OME)-OME;Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate;BOC-GLU(OME)-OME 45G;BOC-L-GLUTAMIC ACID DIMETHYL ESTER;dimethyl(tert-butoxycarbonyl)-L-glutamate;(S)-diMethyl 2-(tert-butoxycarbonylaMino)pentanedioate;BOC-L-GLU(ME)-OME;Dimethyl (2S)-2-(tert-butoxycarbonylamino)pentanedioate
CBNumber:
CB5853917
Molecular Formula:
C12H21NO6
Molecular Weight:
275.3
MDL Number:
MFCD03094774
MOL File:
59279-60-6.mol
MSDS File:
SDS
Last updated:2024-03-26 11:13:42

(R)-N-Boc-glutamic acid-1,5-dimethyl ester Properties

Melting point 43.0 to 47.0 °C
Boiling point 370.9±32.0 °C(Predicted)
Density 1.117±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), DMSO (Slightly)
pka 10.86±0.46(Predicted)
form Liquid
color Colorless to pale yellow
CAS DataBase Reference 59279-60-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
HS Code  2922420090
NFPA 704
0
0 0

(R)-N-Boc-glutamic acid-1,5-dimethyl ester price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical D4536 Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate >98.0%(HPLC)(N) 59279-60-6 1g $30 2024-03-01 Buy
TCI Chemical D4536 Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate >98.0%(HPLC)(N) 59279-60-6 5g $87 2024-03-01 Buy
Alfa Aesar H62056 N-Boc-L-glutamic acid 1,5-dimethyl ester, 97% 59279-60-6 5g $62.65 2024-03-01 Buy
Alfa Aesar H62056 N-Boc-L-glutamic acid 1,5-dimethyl ester, 97% 59279-60-6 25g $260.65 2024-03-01 Buy
TRC B600185 N-Boc-L-glutamicAcid1,5-DimethylEster 59279-60-6 5g $80 2021-12-16 Buy
Product number Packaging Price Buy
D4536 1g $30 Buy
D4536 5g $87 Buy
H62056 5g $62.65 Buy
H62056 25g $260.65 Buy
B600185 5g $80 Buy

(R)-N-Boc-glutamic acid-1,5-dimethyl ester Chemical Properties,Uses,Production

Uses

(R)-N-Boc-glutamic acid-1,5-dimethyl ester can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development and chemical production processes.

Synthesis

Synthesis_59279-60-6
L-glutamic acid (10.0 g, 67.97 mmol) was dissolved in 200 mL of methanol, and SOCl2(10.85 mL, 149.53 mmol)was slowly added dropwise under an ice bath. After the addition, reflux was performed at 65 ?? C. After 2 hours, the reaction system was cooled to room temperature, and methanol was evaporated to dryness under reduced pressure to obtain a colorless viscous substance.This colorless viscous substance was dissolved in 200 mL of THF, (Boc)2O (22.25 g, 101.95 mmol) was addedunder an ice bath, and triethylamine (14.13 mL, 101.95 mmol) was slowly added dropwise.After the addition was complete, the reaction was allowed to proceed at room temperature overnight.After completion of the reaction, the solvent was distilled off under reduced pressure.The residue was dissolved in 200 mL of dichloromethane.The organic phase was washed with water (200 mL * 2), saturated citric acid solution (200 mL * 2), saturated sodium bicarbonate solution (200 mL * 2), and saturated brine (200 mL * 2) in that order.The organic phase was dried over anhydrous Na2SO4. Thefiltrate was collected by filtration, and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography (petroleum ether: ethyl acetate = 4: 1 v / v) to give a colorless oily product (R)-N-Boc-glutamic acid-1,5-dimethyl ester (18.34 g, yield 98%)

(R)-N-Boc-glutamic acid-1,5-dimethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 320)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
AstaTech(Chengdu) Biopharmaceutical Corp.
+86-02882666559 +86-15884417729 gjpu@astatech.com.cn China 308 58
WinWin Chemical CO., Limited
+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 13848 58
weifang runzhong fine chemical co., ltd
536-7868377 +8618653686003 sq@runzhongchem.com China 187 58
Ningxia LabsChem Co., Ltd.
0952-9294929 +8613895679378 48472788@qq.com China 352 58
Hebei Mojin Biotechnology Co., Ltd
+8613288715578 sales@hbmojin.com China 12452 58
Firsky International Trade (Wuhan) Co., Ltd
+8615387054039 admin@firsky-cn.com China 436 58
Anhui Ruihan Technology Co., Ltd
+8617756083858 daisy@anhuiruihan.com China 994 58
Sichuan HongRi Pharma-Tech Co.,Ltd
+86-028-64841719 +8618980456393 daisy@enlaibio.com China 1369 58
Chongqing Zhihe Biopharmaceutical Co., Ltd.
+86-18580541567 +86-17782035140 sales@zhswyy.com China 382 58

View Lastest Price from (R)-N-Boc-glutamic acid-1,5-dimethyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Boc-L-Glu(Ome)-Ome pictures 2024-04-15 Boc-L-Glu(Ome)-Ome
59279-60-6
US $0.00-0.00 / kg 1kg 98% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
(R)-N-Boc-glutamic acid-1,5-dimethyl ester pictures 2024-04-07 (R)-N-Boc-glutamic acid-1,5-dimethyl ester
59279-60-6
US $0.00-0.00 / kg 0.10000000149011612kg 99 20tons Chongqing Zhihe Biopharmaceutical Co., Ltd.
(R)-N-Boc-glutamic acid-1,5-dimethyl ester pictures 2024-01-08 (R)-N-Boc-glutamic acid-1,5-dimethyl ester
59279-60-6
US $32.00 / KG 1KG 99.9 200 Wuhan Boyuan Import & Export Co., LTD
Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate N-ALPHA-TERT-BUTYLOXYCARBONYL-L-GLUTAMIC ACID DI-METHYL DIESTER N-ALPHA-T-BUTYLOXYCARBONYL-L-GLUTAMIC ACID DIMETHYL DIESTER N-ALPHA-T-BUTOXYCARBONYL-L-GLUTAMIC ACID ALPHA, GAMMA-DIMETHYL ESTER (R)-N-BOC-GLUTAMIC ACID-1,5-DIMETHYL ESTER (S)-2-tert-ButoxycarbonylaMinopentanedioic acid diMethyl ester N-alpha-t-Butyloxycarbonyl-L-glutamic acid di-methyl ester Dimethyl (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanedioate N-Boc-L-GlutaMic Acid diMethyl ester/(S)-2-tert-ButoxycarbonylaMino-pentanedioic acid diMethyl ester (S)-2-tert-ButoxycarbonylaMino-pentanedioic acid diMethyl ester N-Boc-L-glutaMic acid 1,5-diMethyl ester, 97% N-α-(t-Butoxycarbonyl)-L-glutamic acid α,γ-dimethyl ester (R)-N-Boc-glutamic acid-1,5-dimethyl ester (PF-07321332 Paxlovid intermediate) Dimethyl Boc-Glutamate 59279-60-6---(R)-N-Boc-glutamic acid-1,5-dimethyl ester 1,5-dimethyl (2S)-2-{[(tert-butoxy)carbonyl]amino}pentanedioate (R)-N-Boc-glutamic acid-1,5-dinethyl ester (Tert-Butoxy)Carbonyl Glu(OMe)-OMe (Syrup) Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate > u(Ome)-OMe L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 1,5-dimethyl ester imethyl(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanedioate N-(tert-Butoxycarbonyl)-L-glutamic Acid Dimethyl Ester Dimethyl N-Boc-L-glutamate (R)-N-Boc-glutamic acid-1,5-dimethyl ester USP/EP/BP Boc-Glu-OMe(OMe) USP/EP/BP BOC-L-GLU(OME)-OME BOC-L-GLUTAMIC ACID DIMETHYL ESTER BOC-GLU(OME)-OME BOC-GLU(OME)-OME 45G N-Boc-L-Glutamic acid dimethyl ester BOC-L-GLU(ME)-OME (S)-diMethyl 2-(tert-butoxycarbonylaMino)pentanedioate Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate dimethyl(tert-butoxycarbonyl)-L-glutamate Dimethyl (2S)-2-(tert-butoxycarbonylamino)pentanedioate 1,5-Dimethyl N-[(1,1-dimethylethoxy)carbonyl]-L-glutamate N-Boc-L-glutamic acid 1,5-dimethyl Dimethyl (S)-(N-tert-butoxycarbonyl)glutamate (R)-N-Boc-glutamic acid-1,5-dimethyl este 59279-60-6 59579-60-6 52979-60-6 1