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Dimethyl ether

Dimethyl ether
Dimethyl ether structure
Chemical Name:
Dimethyl ether
RE170;dymela;RE-170;demeond;(CH3)2O;Dymel A;woodether;Wood ether;FK-506 3'ether,methyl
Molecular Formula:
Formula Weight:
MOL File:

Dimethyl ether Properties

Melting point:
−141 °C(lit.)
Boiling point:
−24.8 °C(lit.)
vapor density 
1.62 (vs air)
vapor pressure 
>760 mm Hg ( 25 °C)
refractive index 
Flash point:
Soluble in acetone, chloroform, ethanol (95%), ether, and 1 in 3 parts of water. Dimethyl ether is generally miscible with water, nonpolar materials, and some semipolar materials. For pharmaceutical aerosols, ethanol (95%) is the most useful cosolvent. Glycols, oils, and other similar materials exhibit varying degrees of miscibility with dimethyl ether.
Chloroform-like; sweet.
Odor Threshold
explosive limit
Water Solubility 
Stable. Extremely flammable. Note low flash point. May form explosive mixtures with air. May form peroxides during prolonged storage.
CAS DataBase Reference
115-10-6(CAS DataBase Reference)
EWG's Food Scores
NIST Chemistry Reference
Dimethyl ether(115-10-6)
EPA Substance Registry System
Dimethyl ether (115-10-6)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H220-H280
Precautionary statements  P210-P377-P381-P410+P403
Hazard Codes  F+
Risk Statements  12
Safety Statements  9-16-33
RIDADR  UN 1033 2.1
WGK Germany  1
RTECS  PM4780000
Autoignition Temperature 662 °F
HazardClass  2.1
NFPA 704
2 1

Dimethyl ether price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 295299 Dimethyl ether ≥99% 115-10-6 100g $174 2019-12-02 Buy
Sigma-Aldrich 295299 Dimethyl ether ≥99% 115-10-6 1kg $408 2019-12-02 Buy
Sigma-Aldrich 295299 Dimethyl ether ≥99% 115-10-6 400g $234 2019-12-02 Buy

Dimethyl ether Chemical Properties,Uses,Production

Chemical Properties

Dimethyl ether is a liquefied gas and exists as a liquid at room temperature when contained under its own vapor pressure, or as a gas when exposed to room temperature and pressure.
It is a clear, colorless, virtually odorless liquid. In high concentrations, the gas has a faint ether-like odor.


Dimethyl ether is used as a solvent in aerosol formulations.


Methyl ether is used as an aerosol propellantand in refrigeration.


Aerosol propellant; alternative diesel fuel; chemical intermediate.


ChEBI: An ether in which the oxygen atom is connected to two methyl groups.

Production Methods

Dimethyl ether is prepared by the reaction of bituminous or lignite coals with steam in the presence of a finely divided nickel catalyst. This reaction produces formaldehyde, which is then reduced to methanol and dimethyl ether. Dimethyl ether may also be prepared by the dehydration of methanol.

General Description

Dimethyl ether is a colorless gas with a faint ethereal odor. Dimethyl ether is shipped as a liquefied gas under its vapor pressure. Contact with the liquid can cause frostbite. Dimethyl ether is easily ignited. Its vapors are heavier than air. Any leak can be either liquid or vapor. Dimethyl ether can asphyxiate by the displacement of air. Under prolonged exposure to fire or intense heat the containers may rupture violently and rocket.

Air & Water Reactions

Highly flammable. Upon standing and exposure to air (oxygen) tendency to form explosive peroxides. When ethers containing peroxides are heated (distilled) they can detonate [Lewis, 3rd ed., 1993, p. 854].

Reactivity Profile

Dimethyl ether is a colorless, highly flammable gas (b. p. -24° C), slightly toxic. Very dangerous fire and explosion hazard when exposed to flame, sparks, heat or strong oxidizers. Violent reaction with aluminum hydride, lithium aluminum hydride. Upon standing and exposure to air (oxygen) tendency to form explosive peroxides. When ethers containing peroxides are heated (distilled) they can detonate [Lewis, 3rd ed., 1993, p. 854].

Health Hazard

Methyl ether produced low inhalation toxicity in rats. Caprino and Togna (1975)reported a 30-minute LC50 value of 396 ppmfor rats. In lethal doses it caused sedation,a gradual depression of motor activity, lossof the sighting reflex, hypopnea, coma, anddeath in mice. Exposure to a 40% mixtureof methyl ether in air resulted in an initialslight increase in heart rate in rabbits, whichwas followed by depression of arterial bloodpressure. Death occurred in 45 minutes. Thearterial and venous partial oxygen pressurewas found to decrease while the venous CO2pressure and the blood pH increased
Reuzel et al. (1981) reported that sub chronic inhalation of methyl ether in ratsdid not cause significant adverse effects.No noticeable effect on organ and bodyweights and no treatment-related changeswere observed. In humans, adverse healtheffect from inhalation of this compoundshould be minimal. However, inhalation ofexcessive quantities can produce intoxicationand loss of consciousness.

Fire Hazard

Behavior in Fire: Containers may explode. Vapors are heavier than air and may travel long distance to a source of ignition and flash back.

Chemical Reactivity

Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Pharmaceutical Applications

Dimethyl ether may be used as an aerosol propellant for topical aerosol formulations in combination with hydrocarbons and other propellants. Generally, it cannot be used alone as a propellant owing to its high vapor pressure. Dimethyl ether is a good solvent and has the unique property of high water solubility, compared to other propellants. It has frequently been used with aqueous aerosols. A coarse, wet, spray is formed when dimethyl ether is used as a propellant.
Dimethyl ether is also used as a propellant in cosmetics such as hair sprays,and in other aerosol products such as air fresheners and fly sprays.
Dimethyl ether is additionally used as a refrigerant.


Dimethyl ether may be used as a propellant and solvent in topical pharmaceutical aerosols, and is generally regarded as an essentially nontoxic and nonirritant material when used in such applications. However,inhalation of high concentrations of dimethyl ether vapor is harmful. Additionally, skin contact with dimethyl ether liquid may result in freezing of the skin and severe frostbite.
When used in topical formulations, dimethyl ether may exert a chilling effect on the skin, although if it is used as directed the propellant quickly vaporizes and is nonirritating.
LD50 (mouse, inhalation): 386000ppm/30min
LD50 (rat, inhalation): 308g/m3


A lifetime study in rats did not produce cancer or clear, statistically significant evidence of chronic toxicity at 25,000 ppm of dimethyl ether.


The liquefied gas is stable when used as a propellant. However, exposure to the air for long periods of time may result in explosive peroxides being slowly formed.
Solutions of liquid dimethyl ether should not be concentrated either by distillation or by evaporation. Dimethyl ether should be stored in tightly closed metal cylinders in a cool, dry place.

Purification Methods

Dry methyl ether by passing over alumina and then BaO, or over CaH2, followed by fractional distillation at low temperatures. Its solubility is 37mL per mL of H2O at 18o, and it is very soluble


Dimethyl ether is an aggressive solvent and may affect the gasket materials used in aerosol packaging. Oxidizing agents, acetic acid, organic acids, and anhydrides should not be used with dimethyl ether.

Regulatory Status

Included in the FDA Inactive Ingredients Database (topical aerosols). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Dimethyl ether Preparation Products And Raw materials

Raw materials

Preparation Products

Dimethyl ether Suppliers

Global( 72)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21838 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22625 55
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23045 58
86-18523575427 CHINA 47486 58
13806087780 +86 13806087780 CHINA 17852 58
Mainchem Co., Ltd. +86-0592-6210733
+86-0592-6210733 CHINA 32444 55
Meryer (Shanghai) Chemical Technology Co., Ltd. 400-660-8290 21-61259100-
86-21-61259102 China 40268 62
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202-
+86-21-64545202; China 43258 64
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
86-21-63290778 86-21-63218885 China 9848 79
Beijing HuaMeiHuLiBiological Chemical 010-56205725
010-65763397 China 12341 58

View Lastest Price from Dimethyl ether manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-12-31 Methyl Ether
US $1.00 / KG 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd

Dimethyl ether Spectrum

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