Prazosin hydrochloride
- CAS No.
- 19237-84-4
- Chemical Name:
- Prazosin hydrochloride
- Synonyms
- PRAZOSIN HCL;hypovase;pratsiol;sinetens;Vasoflex;peripress;Adversuten;Alpress LP;cp-12299-1;deprazolin
- CBNumber:
- CB6120870
- Molecular Formula:
- C19H22ClN5O4
- Molecular Weight:
- 419.86
- MDL Number:
- MFCD00058177
- MOL File:
- 19237-84-4.mol
- MSDS File:
- SDS
Melting point | 277 - 280 °C |
---|---|
storage temp. | 2-8°C |
solubility | H2O: 1 mg/mL, clear, colorless |
form | solid |
color | white |
Water Solubility | Soluble in dimethyl sulfoxide, ethanol, water, methanol. |
Merck | 14,7717 |
BRN | 4303561 |
InChIKey | WFXFYZULCQKPIP-UHFFFAOYSA-N |
CAS DataBase Reference | 19237-84-4(CAS DataBase Reference) |
FDA UNII | X0Z7454B90 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS08 |
|||||||||
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335-H361 | |||||||||
Precautionary statements | P201-P301+P312+P330-P302+P352-P305+P351+P338-P308+P313 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 22-36/37/38-62 | |||||||||
Safety Statements | 28-36 | |||||||||
RIDADR | 3249 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | VA1350000 | |||||||||
F | 10 | |||||||||
HazardClass | 6.1(b) | |||||||||
PackingGroup | III | |||||||||
HS Code | 2934990002 | |||||||||
Toxicity | dog,LD50,oral,> 700mg/kg (700mg/kg),GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDSKIDNEY, URETER, AND BLADDER: OTHER CHANGES GASTROINTESTINAL: NAUSEA OR VOMITING,Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979. | |||||||||
NFPA 704 |
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Prazosin hydrochloride price More Price(39)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | PHR3099 | Prazosin Hydrochloride pharmaceutical secondary standard, certified reference material | 19237-84-4 | 500MG | $229 | 2024-03-01 | Buy |
Sigma-Aldrich | P7791 | Prazosin hydrochloride ≥99.0% (HPLC) | 19237-84-4 | 1g | $906 | 2024-03-01 | Buy |
Sigma-Aldrich | 1554705 | Prazosin hydrochloride United States Pharmacopeia (USP) Reference Standard | 19237-84-4 | 350mg | $436 | 2024-03-01 | Buy |
TCI Chemical | P0938 | Prazosin Hydrochloride >98.0%(T) | 19237-84-4 | 100mg | $66 | 2024-03-01 | Buy |
TCI Chemical | P0938 | Prazosin Hydrochloride >98.0%(T) | 19237-84-4 | 1g | $244 | 2024-03-01 | Buy |
Prazosin hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Off-White to Yellow Powder
Originator
Hypovase, Pfizer, UK,1974
Uses
Prazosin Hydrochloride (Terazosin EP Impurity K) is an antihypertensive. α1-Adrenergic blocker.
Uses
Prazosin hydrochloride has been used:
- to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in mice
- as an α1-adrenoceptor blocker,administered intragastrically in rats
- as a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions
Manufacturing Process
Preparation of 2-Chloro-4-Amino-6,7-Dimethoxyquinazoline: To 800 ml of a solution of anhydrous ammonia in tetrahydrofuran at room temperature is added 30 g of 2,4-dichloro-6,7-dimethoxyquinazoline [F.H.S. Curd et al., J. Chem. Soc., p 1759 (1948)]. The mixture is stirred for 44 hours. The precipitate (29 g, MP 267° to 268°C) is filtered and recrystallized from methanol to yield 19 g of 2-chloro-4-amino-6,7-dimethoxyquinazoline, MP 302°C (dec.).
Preparation of 2-(1-Piperazinyl)-4-Amino-6,7-Dimethoxyquinazoline: To 5 g of 2-chloro-4-amino-6,7-dimethoxyquinazoline, is added 20 g of a 25% solution of piperazine in ethanol. The mixture is heated at 160°C for 16 hours in a pressure bottle. The solvent is then evaporated and the residue is recrystallized from methanol/water.
Preparation of 2[4-(2-Furoyl)-Piperazinyl]-4-Amino-6,7-Dimethoxyquinazoline: To 0.10 mol 2-(1-piperazinyl)-4-amino-6,7-dimethoxyquinazoline in 300 ml methanol is added with vigorous stirring, 0.10 mol 2-furoyl chloride. After addition is complete, the mixture is stirred for 3 hours at room temperature. The solids are filtered to give the desired product, MP 278° to 280°C.
brand name
Minipress (Pfizer).
Therapeutic Function
Antihypertensive
General Description
The antihypertensive effectsof prazosin hydrochloride, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazine monohydrochloride(Minipress), are caused by peripheral vasodilation as a resultof its blockade of 1-adrenergic receptors. In ligand-bindingstudies, prazosin hydrochloride has 5,000-fold greater affinityfor α1-receptors than for some α2-adrenergic receptors.
Biological Activity
α 1 and α 2B -adrenoceptor antagonist. Also a potent antagonist at the melatonin MT 3 receptor (K i = 10.2 nM). Also available as part of the α 1 -Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™ .
Biochem/physiol Actions
Peripheral α1-adrenoceptor antagonist; vasodilator. Prazosin can be used to treat chronic posttraumatic stress disorder (PTSD). It plays a role in reducing blood pressure by relaxing blood vessels, hence used in the treatment of high blood pressure.
Clinical Use
Prazosin hydrochloride is readily absorbed, and plasmaconcentrations reach a peak about 3 hours after administration.Plasma half-life is between 2 and 3 hours. Prazosin hydrochlorideis highly bound to plasma protein; it does notcause adverse reactions, however, with drugs that might bedisplaced from their protein-binding sites (e.g., cardiac glycosides).It may cause severe orthostatic hypertension becauseof its -adrenergic blocking action, which preventsthe reflex venous constriction that is activated when an individualsits up from a prone position.
storage
Room temperature
Purification Methods
The salt is recrystallised by dissolving it in hot MeOH, adding a small volume of MeOH/HCl (dry MeOH saturated with dry HCl gas) followed by dry Et2O until crystallisation is complete. Dry it in vacuo over solid KOH till the odour of HCl is absent. It has been recrystallised from hot H2O, the crystals are washed with H2O, and the H2O is removed azeotropically with CH2Cl2, and dried in a vacuum. [NMR and IR: Honkanen et al. J Heterocycl Chem 17 797 1980, cf Armarego & Reece Aust J Chem 34 1561 1981.] It is an antihypertensive drug and is an 1-adrenergic antagonist [Brosman et al. Proc Natl Acad Sci USA 82 5915 1985].
Prazosin hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14335 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
View Lastest Price from Prazosin hydrochloride manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-11-04 | Prazosin hydrochloride
19237-84-4
|
US $10.00 / Kg/Bag | 1Kg/Bag | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd | ||
2021-11-02 | Prazosin hydrochloride
19237-84-4
|
US $1269.00 / Kg/Bag | 100g | 98%+ | 500kg | Baoji Guokang Healthchem co.,ltd | ||
2021-07-13 | Prazosin hydrochloride
19237-84-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
- Prazosin hydrochloride
19237-84-4
- US $10.00 / Kg/Bag
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
- Prazosin hydrochloride
19237-84-4
- US $1269.00 / Kg/Bag
- 98%+
- Baoji Guokang Healthchem co.,ltd
- Prazosin hydrochloride
19237-84-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd