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Chlormethine hydrochloride

Chlormethine hydrochloride
Chlormethine hydrochloride structure
CAS No.
55-86-7
Chemical Name:
Chlormethine hydrochloride
Synonyms
c6866;pliva;SK 101;erasol;n-lost;zagreb;antimit;dimitan;EMBICHINE;Mustargen
CBNumber:
CB6267542
Molecular Formula:
C5H12Cl3N
Formula Weight:
192.51
MOL File:
55-86-7.mol

Chlormethine hydrochloride Properties

Melting point:
108-111 °C(lit.)
Boiling point:
315.95°C (rough estimate)
Density 
1.4424 (rough estimate)
refractive index 
1.6300 (estimate)
storage temp. 
−20°C
solubility 
H2O: very soluble
pka
pKa 6.43 (Uncertain)
Sensitive 
Hygroscopic
Merck 
13,5798
Stability:
Stable. Hygroscopic.
CAS DataBase Reference
55-86-7(CAS DataBase Reference)
EPA Substance Registry System
Ethanamine, 2-chloro-N-(2-chloroethyl)- N-methyl-, hydrochloride(55-86-7)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T+
Risk Statements  45-46-28-34-42/43-27/28-61
Safety Statements  53-36/37/39-45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  IA2100000
TSCA  Yes
HazardClass  6.1(a)
PackingGroup  II
Hazardous Substances Data 55-86-7(Hazardous Substances Data)
Toxicity LD50 in rats (mg/kg): 1.1 i.v.; 1.9 s.c. (Anslow)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger P264, P270, P301+P310, P321, P330,P405, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger
Precautionary statements:
P201 Obtain special instructions before use.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P350 IF ON SKIN: Gently wash with plenty of soap and water.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Chlormethine hydrochloride price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 122564 Mechlorethamine hydrochloride 98% 55-86-7 5g $131 2018-11-22 Buy
Sigma-Aldrich 122564 Mechlorethamine hydrochloride 98% 55-86-7 25g $414 2018-11-22 Buy

Chlormethine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

White Solid

Chemical Properties

Highly toxic white to yellowish crystalline solid or powder. May be available as an unstable aqueous solution. Fish-like odor.

Uses

xanthine oxidase/dehydrogenase inhibitor

Uses

It has been used as an antineoplastic. A nitrogen mustard prepared by action of thionyl chloride on 2,2’(methylimino)- diethanol in trichloroethylene.

Definition

ChEBI: The hydrochloride salt of mechlorethamine.

Indications

Mechlorethamine (Mustargen) is a cytotoxic alkylating agent. Topical application of freshly prepared aqueous solutions are used in patients with early stages of cutaneous T-cell lymphoma. A major disadvantage to the use of this drug is the rapid induction of allergic contact dermatitis in some patients.

Indications

Mechlorethamine (nitrogen mustard; Mustargen), a derivative of the war gas sulfur mustard, is considered to be the first modern anticancer drug. In the early 1940s it was discovered to be effective in the treatment of human lymphomas.

brand name

Mustargen (Ovation).

General Description

White to off-white crystals or powder with a fishy odor. Initial pH (2% aqueous solution) 3.0-4.0.

General Description

Mechlorethamine is available in 10-mg vials for intravenous(IV) administration in the treatment of Hodgkin’slymphoma. It is part of the MOPP regimen used in treatingthis condition, which is comprised of mechlorethamine,vincristine (Oncovin), procarbazine, and prednisone. Theagent is also used topically in the treatment of mycosis fungoides,a rare type of cancer but the most common type ofcutaneous T-cell lymphoma. Additional uses have includedtreatment of cancers that have resulted in pleural effusion.Although the compound is a potent alkylating agent, resistancemay develop as a result of increased inactivation bysulfhydryl containing proteins such as glutathione andincreased expression of DNA repair mechanisms. Adverseeffects include dose-limiting myelosuppression and nausea/vomiting. There is a significant risk of extravasationupon IV administration, and the agent may produce painat the injection site. Additional adverse effects include alopecia, azoospermia, amenorrhea, hyperuricemia, and anincreased risk of secondary cancers.

Air & Water Reactions

Hygroscopic. Water soluble.

Reactivity Profile

Dry crystals are stable at temperatures up to 104° F. Chlormethine hydrochloride is incompatible with strong oxidizing agents. .

Hazard

Highly toxic, vesicant, and strongly irritant to mucous membranes.

Fire Hazard

Flash point data for Chlormethine hydrochloride are not available. Chlormethine hydrochloride is probably combustible.

Mechanism of action

Mechlorethamine in aqueous solution loses a chloride atom and forms a cyclic ethylenimmonium ion.This carbonium ion interacts with nucleophilic groups, such as the N7 and O6 of guanine, and leads to an interstrand cross-linking of DNA. Although there is great variation among normal and tumor tissues in their sensitivity to mechlorethamine, the drug is generally more toxic to proliferating cells than to resting or plateau cells. Mechlorethamine has a chemical and biological half-life in plasma of less than 10 minutes after intravenous injection. Little or no intact drug is excreted in urine.
The major indication for mechlorethamine is Hodgkin’s disease; the drug is given in the MOPP regimen. Other less reactive nitrogen mustards are now preferred for the treatment of non- Hodgkin’s lymphomas, leukemias, and various solid tumors.

Side effects

The dose-limiting toxicity of mechlorethamine is myelosuppression; maximal leukopenia and thrombocytopenia occur 10 to 14 days after drug administration, and recovery is generally complete at 21 to 28 days. Lymphopenia and immunosuppression may lead to activation of latent herpes zoster infections, especially in patients with lymphomas. Mechlorethamine will affect rapidly proliferating normal tissues and cause alopecia, diarrhea, and oral ulcerations. Nausea and vomiting may occur 1 to 2 hours after injection and can last up to 24 hours. Since mechlorethamine is a potent blistering agent, care should be taken to avoid extravasation into subcutaneous tissues or even spillage onto the skin. Reproductive toxicity includes amenorrhea and inhibition of oogenesis and spermatogenesis. About half of premenopausal women and almost all men treated for 6 months with MOPP chemotherapy become permanently infertile. The drug is teratogenic and carcinogenic in experimental animals.

Shipping

UN2928 Toxic solids, corrosive, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, 8-Corrosive material, Technical Name Required. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Waste Disposal

It is not appropriate to dispose of expired or waste product such as lab chemicals by flushing them down the toilet or discarding them to the trash. Larger quantities shall carefully take into consideration applicable EPA, and FDA regulations. If possible return the lab chemicals to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste lab chemicals shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Chlormethine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Chlormethine hydrochloride Suppliers

Global( 166)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32452 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 539 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25796 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23957 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 303 58
Hubei xin bonus chemical co. LTD
13657299721
zhangyuzhu@xhlchem.com CHINA 17425 58
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15882 69
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 5997 61

View Lastest Price from Chlormethine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-01 Chlormethine hydrochloride
55-86-7
US $100.00 / KG 1KG 99% Customized career henan chemical co
2019-04-10 Chlormethine hydrochloride
55-86-7
US $1.00 / g 10g 99% 5000 Kilograms Cangzhou Wanyou New Material Technology Co.,Ltd

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