1-(3-Chlorphenyl)piperazine
- CAS No.
- 6640-24-0
- Chemical Name:
- 1-(3-Chlorphenyl)piperazine
- Synonyms
- MCPP;1-(3-CHLOROPHENYL)PIPERAZINE;CHLOROPHENYLPIPERAZINE;m-Chlorophenylpiperazine;NSC 49307;AKOS BBS-00003580;TIMTEC-BB SBB003579;RARECHEM AH CK 0071;1,3ChlorofenylPiperazine;3-chlorophenyl piperazine
- CBNumber:
- CB6325545
- Molecular Formula:
- C10H13ClN2
- Molecular Weight:
- 196.68
- MDL Number:
- MFCD00040732
- MOL File:
- 6640-24-0.mol
| Melting point | 210-214°C |
|---|---|
| Boiling point | 105 °C |
| Density | 1.193 |
| refractive index | 1,598-1,600 |
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| solubility | Chloroform (Slightly), Methanol (Sparingly) |
| form | Oil |
| pka | 8.85±0.10(Predicted) |
| color | Colourless to Orange |
| LogP | 2.468 |
| CAS DataBase Reference | 6640-24-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | REY0CNO998 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS09 |
|---|---|
| Hazard statements | H411 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39-36 |
| HazardClass | IRRITANT |
| HS Code | 29339900 |
1-(3-Chlorphenyl)piperazine Chemical Properties,Uses,Production
Chemical Properties
clear colorless to light yellow oily liquid
Uses
It is noteworthy that 1-(3-Chlorphenyl)piperazine (m-CPP), resulting from N-dealkylation of Trazodone, is a major circulating metabolite in humans common to several antidepressants including Trazodone, Nefazodone, and Etoperidone. The metabolite m-CPP is of significant interest because it has 5-HT2C agonistic and 5-HT2A antagonistic properties. It has also been suggested that m-CPP may contribute to the antidepressant efficacy of Trazodone.
Uses
It is noteworthy that 1-(3-Chlorphenyl)piperazine (m-CPP), resulting from N-dealkylation of Trazodone, is a major circulating metabolite in humans common to several antidepressants including Trazodone, Nefazodone, and Etoperidone (1,2,3). The metabolite m-CPP is of significant interest because it has 5-HT2C agonistic and 5-HT2A antagonistic properties. It has also been suggested that m-CPP may contribute to the antidepressant efficacy of Trazodone.
Definition
ChEBI: A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.
Hazard
A poison.
1-(3-Chlorphenyl)piperazine Preparation Products And Raw materials
Raw materials
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Preparation Products
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