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o-Cresolphthalein

CAS No.
596-27-0
Chemical Name:
o-Cresolphthalein
Synonyms
cresolphthalein;o-Cresolphalein;o-Cresolphthalei;o-cresolphtaleine;O-CRESOLPHTHALEIN;O-Cresolphtnalein;3,3-Bis(4-hydroxy-;Cresolphthanalein;o-CRESOLPHTHLALEIN;TIMTEC-BB SBB006498
CBNumber:
CB6392671
Molecular Formula:
C22H18O4
Molecular Weight:
346.38
MDL Number:
MFCD00005912
MOL File:
596-27-0.mol
MSDS File:
SDS
Last updated:2023-08-11 16:54:45

o-Cresolphthalein Properties

Melting point 223-225 °C
Boiling point 401.12°C (rough estimate)
Density 1.1425 (rough estimate)
refractive index 1.4400 (estimate)
solubility Solubility Slightly soluble in water; soluble in ethanol
form powder
pka 9.40(at 25℃)
color Clear colorless
PH Range 8.2 (colorless) - 9.8 (violet/red)
Water Solubility slightly soluble
λmax 566nm, 381nm
Merck 14,2576
BRN 310554
Major Application Sensors, display device, photoresists, recording materials, imaging materials, authentication system for secure documents, decoder system, lithium cells, electroplating process, inks, markers, toners, correction fluid, paints, adhesives, floor coatings, gas leaking detector for safety in industries, toys, food storage, diapers, determination of calcium, lotions, urine analysis test strips, drugs, blood analysis
InChIKey CPBJMKMKNCRKQB-UHFFFAOYSA-N
CAS DataBase Reference 596-27-0(CAS DataBase Reference)
FDA UNII XOU2D9049G
EPA Substance Registry System 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxy-3-methylphenyl)- (596-27-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07,GHS08
Signal word  Danger
Hazard statements  H225-H319-H335+H336-H340-H360-H372-H373
Precautionary statements  P201-P202-P210-P233-P240-P241+P242+P243-P260-P264-P270-P271-P280-P303+P361+P353-P304+P340+P312-P305+P351+P338+P337+P313-P308+P313-P403+P233-P405-P501
Hazard Codes  Xn
Risk Statements  40-36/37/38-20/21/22
Safety Statements  36/37-36-26
RIDADR  1170
WGK Germany  3
RTECS  SM8390000
TSCA  Yes
HS Code  3822.19.0080
NFPA 704
0
1 0

o-Cresolphthalein price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C85778 o-Cresolphthalein indicator grade 596-27-0 10g $58.4 2024-03-01 Buy
TCI Chemical C0404 o-Cresolphthalein 596-27-0 25g $65 2024-03-01 Buy
TCI Chemical C0404 o-Cresolphthalein 596-27-0 100g $171 2024-03-01 Buy
Alfa Aesar A12899 o-Cresolphthalein 596-27-0 10g $35.7 2024-03-01 Buy
Alfa Aesar A12899 o-Cresolphthalein 596-27-0 50g $113 2024-03-01 Buy
Product number Packaging Price Buy
C85778 10g $58.4 Buy
C0404 25g $65 Buy
C0404 100g $171 Buy
A12899 10g $35.7 Buy
A12899 50g $113 Buy

o-Cresolphthalein Chemical Properties,Uses,Production

Chemical Properties

white to pink or beige to tan powder. soluble in ethanol, ether, glacial acetic acid, soluble in dilute alkali and turns purple, slightly soluble in water, hardly soluble in benzene.

Uses

O-Cresolphthalein has been used as a component in calcifying media for calcification assay. It is also used as an indicator (pH range, 8.2 colorless, 9.8 red) and analytical reagent.

Application

O-Cresolphthalein is a gadolinium chelate that is used as a contrast agent for magnetic resonance imaging (MRI) of the brain, spine, and joints. The gadolinium ion is bound to the cresol molecule, which has an attached hydroxyl group. This complex attaches to the phosphorous pentoxide and creates a precipitate of metal hydroxides in the presence of water and sodium carbonate. O-Cresolphthalein is also used in clinical pathology to measure glomerular filtration rate (GFR), which is important for diagnosing renal disease. MRI scans are used to diagnose osteogenic genes that are associated with bone diseases such as osteoporosis.

Biochem/physiol Actions

o-Cresolphthalein is a reversible pH indicator. The kinetics of the reverse pathway (red-purple to colorless) is slow, thereby making it an appropriate molecule to check flow patterns in ducts with corrugated walls. It is also used for the colorimetric determination of calcium content via the o-cresolphthalein complexone method. Binding of calcium to o-cresolphthalein, in the presence of alkaline conditions (pH 10-12), results in the formation of a red complex with an absorbance at 570-575nm.

85-44-9
95-48-7
108-95-2
77-09-8
854-76-2
596-27-0
Synthesis of o-Cresolphthalein from Phthalic anhydride and o-Cresol and Phenol

o-Cresolphthalein Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 331)Suppliers
Supplier Tel Email Country ProdList Advantage
Honest Joy Holdings Limited
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Shenyang Simchoice Chemical Co.,Ltd
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+86 18953170293 sales@sdzschem.com China 2931 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715 admin@nexconn.com China 10248 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 alice@crovellbio.com China 8823 58

View Lastest Price from o-Cresolphthalein manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
o-Cresolphthalein pictures 2024-04-08 o-Cresolphthalein
596-27-0
US $18.50 / Kg/Drum 25KG 95.0% 500kg per month Shenyang Simchoice Chemical Co.,Ltd
o-Cresolphthalein pictures 2023-08-12 o-Cresolphthalein
596-27-0
US $0.00-0.00 / kg 1kg 0.99 50000kg Hebei Kingfiner Technology Development Co. , Ltd.
 o-Cresolphthalein  pictures 2023-06-15 o-Cresolphthalein
596-27-0
US $48.00 / Kg/Drum 25KG 98% 1-10mt Baoji Guokang Bio-Technology Co., Ltd.
  • o-Cresolphthalein pictures
  • o-Cresolphthalein
    596-27-0
  • US $18.50 / Kg/Drum
  • 95.0%
  • Shenyang Simchoice Chemical Co.,Ltd
  • o-Cresolphthalein pictures
  • o-Cresolphthalein
    596-27-0
  • US $0.00-0.00 / kg
  • 0.99
  • Hebei Kingfiner Technology Development Co. , Ltd.
3’,3’’-dimethyl-phenolphthalei cresolphthalein Di-o-Cresolphthalide o-Cresolphalein o-cresolphtaleine 3,3-bis(4-hydroxy-3-methylphenyl)-(3H)-Isobenzofuranone 3,3-bis(4-hydroxy-3-methylphenyl)-1(3h)-isobenzofuranon 3,3-Bis(4-hydroxy-3-methylphenyl)-1-(3H)-iso-benzofuranone 3,3-bis(4-hydroxy-3-methylphenyl)-1(3h)-isobenzofuranone 3,3'-DIMETHYLPHENOLPHTHALEIN LABOTEST-BB LT00451717 O-CRESOLPHTHALEIN TIMTEC-BB SBB006498 3,3-bis(4-hydroxy-m-tolyl)phthalide o-Cresollphthalein (0.04% in ca. ethanol) o-Cresolphthalein (0.1% in ca. 90% ethanol) ortho-cresolphthalein 3,3-Bis(3-methyl-4-hydroxyphenyl)phthalide 3,3-Bis(4-hydroxy-3-methylphenyl)-2-benzofuran-1-one O-CRESOLPHTHALEIN INDICATOR ORTHO-CRESOLPHTHALEIN, INDICATOR GRADE O-Cresolphthaleine(PhIndicator) O-Cresolphtnalein o-CRESOLPHTHALEIN (pH INDICATOR) o-Cresolphthalein/CH o-Cresolphthalein, indicator grade, pure o-Cresolphthalein (0.04% in ca. 95% Ethanol) [for pH Determination] 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxy-3-methylphenyl)- o-Cresolphthalein p.a. o-CRESOLPHTHALEIN SOLUTION 0.04% in ALCOHOL o-Cresolphthalein (0.1% in ca. 90% Ethanol) [for Titration] 3,3-Bis(3-methyl-4-hydroxyphenyl)isobenzofuran-1(3H)-one 3,3-Bis(4-hydroxy-3-methylphenyl)isobenzofuran-1(3H)-one o-Cresolphthalein, indicator grade,98% o-Cresolphthalein,pure,indicator grade (0.04% in ca. 95% Ethanol) [for pH DeterMination] o-Cresolphthalein  o-Cresolphthalei 3,3-Bis(4-hydroxy-3-methylphenyl) O-Cresolphthalein extrapure 25GM o-Cresolphthalein - Cas NO.: 596-27-0 o-Cresolphthalein AR, 95% o-Cresolphthalein USP/EP/BP O-cresolphthalein indicator (8.2-9.8) 3,3-Bis(4-hydroxy- O-Cresolphthalein CAS 596-27-0 O-Cresolphthalein extrapure 5GM Cresolphthanalein O-cresolphthalein alcohol soluble o-methylphenolphthalein o-CRESOLPHTHLALEIN 596-27-0 5966-27-0 C22H18C4 C33H18O4 C22H18O4 Indicator (pH) pH Indicators