8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt
- CAS No.
- 56932-43-5
- Chemical Name:
- 8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt
- Synonyms
- NSC 87877 sodium;NAPHTHYLAZOXINE S;NAPHTHYLAZOXINE 6S;NSC-87877 disodium;NSC-87877(sodium salt);nsc-87877 disodium salt;NSC87877/Naphthylazoxine6S;NAPHTHYLAZOXINE S DISODIUM SALT;NSC-87877 disodium, 10 mM in DMSO;SHP1/2 PTPase Inhibitor, NSC-87877
- CBNumber:
- CB6408024
- Molecular Formula:
- C19H11N3Na2O7S2
- Molecular Weight:
- 503.42
- MDL Number:
- MFCD00041863
- MOL File:
- 56932-43-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | Inert atmosphere,Room Temperature |
|---|---|
| solubility | water: 10 mg/mL |
| form | Solid |
| color | Brown to black |
| Water Solubility | water: 10mg/mL |
| InChIKey | YOGRUDWAJPVHEL-LLDDCTHSSA-L |
| SMILES | [Na+].[Na+].[S](=O)(=O)([O-])c1cc2c(cc(cc2)N\N=C3/C=C(c4c(nccc4)C/3=O)[S](=O)(=O)[O-])cc1 |
| EPA Substance Registry System | 5-Quinolinesulfonic acid, 8-hydroxy-7-[(6-sulfo-2-naphthalenyl)azo]-, disodium salt (56932-43-5) |
| UNSPSC Code | 12352200 |
| NACRES | NA.54 |
SAFETY
Risk and Safety Statements
| Safety Statements | 24/25 |
|---|---|
| WGK Germany | WGK 2 |
| TSCA | TSCA listed |
| Storage Class | 11 - Combustible Solids |
8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 565851 | SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem | 56932-43-5 | 50MG | $175 | 2026-04-30 | Buy |
| ChemScene | CS-0045315 | NSC-87877 disodium 98.0% | 56932-43-5 | 5mg | $65 | 2026-06-04 | Buy |
| ChemScene | CS-0045315 | NSC-87877 disodium 98.0% | 56932-43-5 | 10mg | $108 | 2026-06-04 | Buy |
| ChemScene | CS-0045315 | NSC-87877 disodium 98.0% | 56932-43-5 | 25mg | $217 | 2026-06-04 | Buy |
| ChemScene | CS-0045315 | NSC-87877 disodium 98.0% | 56932-43-5 | 50mg | $379 | 2026-06-04 | Buy |
8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt Chemical Properties, Uses, Production
Chemical Properties
dark red to red-brown powder
Uses
NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2].
Biological Activity
Cell permeable: yes', 'Primary Target
SHP1/2 PTPase', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 355 nM and 318 nM against SHP-1 and SHP-2 protein tyrosine phosphatases, respectively
in vivo
NSC-87877 (30mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity[3].
| Animal Model: | Intrarenal neuroblastoma (NB) tumor mouse model in female nude mice[3]. |
| Dosage: | 30mg/kg. |
| Administration: | IP once daily for 15 days. |
| Result: | Significantly inhibited NB tumor growth. |
References
[1] Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70. DOI:10.1124/mol.106.025536
[2] Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5. DOI:10.1016/j.bbrc.2009.02.069
[3] Y Shi, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6(8):e1841. DOI:10.1038/cddis.2015.207
8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Hubei Jusheng Technology Co.,Ltd | 027-59599241 18871490274 | 1400878000@qq.com | China | 9491 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 87240 | 60 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28149 | 68 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Guangzhou Tomums Life Science Co., Ltd. | 020-31155029 18902330969 | sales@tomums.cn | China | 4688 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
View Latest Price from 8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | NSC-87877 disodium
56932-43-5
|
$39.00-117.00 | 98.00% | 10g | TargetMol Chemicals Inc. |
-
- NSC-87877 disodium
56932-43-5
- $39.00-117.00
- 98.00%
- TargetMol Chemicals Inc.
56932-43-5 (8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt) Related Search:
1of4
