L-(-)-Histidinol dihydrochloride
- CAS No.
- 1596-64-1
- Chemical Name:
- L-(-)-Histidinol dihydrochloride
- Synonyms
- (S)-B2;(±)-Midodrin;H-HIS-OL 2HCL;L-HISTIDINOL 2 HCL;L-(-)-Histidinol dih;L-HISTIDINE DIHYDROCHLORIDE;L-Histidinol·2hydrochloride;L-HISTIDINOL DIHYDROCHLORIDE;L-Histidinol (hydrochloride);L-histidinol dihydrochloroide
- CBNumber:
- CB6666879
- Molecular Formula:
- C6H13Cl2N3O
- Molecular Weight:
- 214.09
- MDL Number:
- MFCD00078058
- MOL File:
- 1596-64-1.mol
| Melting point | 198-201 °C (dec.)(lit.) |
|---|---|
| alpha | -3 º (C=2, H2O 24 ºC) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Sparingly) |
| form | Crystalline Powder |
| color | White to slightly beige |
| BRN | 3914853 |
| InChIKey | FRCAFNBBXRWXQA-XRIGFGBMSA-N |
| CAS DataBase Reference | 1596-64-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-36-37/39-36/37-22 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NI8260000 | |||||||||
| HS Code | 29332900 | |||||||||
| NFPA 704 |
|
L-(-)-Histidinol dihydrochloride price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H6647 | L-Histidinol dihydrochloride ≥98 (TLC) | 1596-64-1 | 1g | $189 | 2024-03-01 | Buy |
| Sigma-Aldrich | H6647 | L-Histidinol dihydrochloride ≥98 (TLC) | 1596-64-1 | 5g | $741 | 2024-03-01 | Buy |
| Cayman Chemical | 18739 | L-Histidinol (hydrochloride) ≥95% | 1596-64-1 | 500mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 18739 | L-Histidinol (hydrochloride) ≥95% | 1596-64-1 | 1g | $138 | 2024-03-01 | Buy |
| Sigma-Aldrich | H6647 | L-Histidinol dihydrochloride ≥98 (TLC) | 1596-64-1 | 10mg | $38.1 | 2024-03-01 | Buy |
L-(-)-Histidinol dihydrochloride Chemical Properties,Uses,Production
Description
L-Histidinol is a natural amino alcohol that serves as an intermediate in the biosynthesis of the amino acid L-histidine in bacteria, archaebacteria, fungi, and plants. It is generated from its immediate precursor, L-histidinol phosphate, by a phosphatase. L-Histidinol is oxidized to L-histidinal, which in turn is oxidized to L-histidine, by a single enzyme, histidinol dehydrogenase.
Chemical Properties
white to slightly beige crystalline powder
Uses
A metabolite within Histidine metabolism.
Definition
ChEBI: L-Histidinol dihydrochloride is an aralkylamine.
in vitro
preliminary experiments were done to investigate the cytotoxic effect of l-histidinol on cultured eac cells. results showed that l-histidinol up to 4 mm had no cytotoxic effects on eac cells. doxorubicin alone showed concentration-dependent cytotoxic effects. l-histidinol combination with doxorubicin led to significant potentiation of doxorubicin cytotoxicity to eac cells compared to doxorubicin alone. the concentration that caused 50% growth inhibition in eac cells after 24 h incubation was about 0.2 μg/ml, whereas it was 0.1 μg/ml when l-histidinol was added to culture medium [1].
in vivo
l-histidinol at 250 mg/kg for five consecutive doses before doxorubicin single injection could enhance the antitumour activity of doxorubicin in eac-bearing mice as demonstrated by a significant increase in average life span and cure rate of mice. in normal mice, l-histidinol, in the same dose regimen, could not alter the acute cardiotoxicity and lethality of doxorubicin [1].
References
[1] al-shabanah oa, badary oa, al-gharably nm, al-sawaf ha. effects of l-histidinol on the antitumour activity and acute cardiotoxicity of doxorubicin in mice. pharmacol res. 1998 sep;38(3):225-30.
L-(-)-Histidinol dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
L-(-)-Histidinol dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21149 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
View Lastest Price from L-(-)-Histidinol dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-28 | L-(-)-Histidinol dihydrochloride
1596-64-1
|
US $35.00 / kg | 1kg | 99% | 5000 tons | Hebei Duling International Trade Co. LTD | |
 |
2020-01-09 | L-(-)-Histidinol dihydrochloride
1596-64-1
|
US $1.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- L-(-)-Histidinol dihydrochloride
1596-64-1
- US $35.00 / kg
- 99%
- Hebei Duling International Trade Co. LTD
-
- L-(-)-Histidinol dihydrochloride
1596-64-1
- US $1.00 / KG
- 99%
- Career Henan Chemical Co