o-프탈알데히드
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o-프탈알데히드 속성
- 녹는점
- 55-58 °C(lit.)
- 끓는 점
- 83-84 °C (0.7501 mmHg)
- 밀도
- 1.13
- 증기압
- 0.56Pa at 25℃
- 굴절률
- 1.4500 (estimate)
- 인화점
- >230 °F
- 저장 조건
- 2-8°C
- 용해도
- o-프탈알데히드의 용해도는 20°C에서 3g/100mL 디이소프로필 에테르, 5g/100mL 탈이온수, 20g/100mL 클로로포름 또는 20g/100mL 아세톤입니다.
- 물리적 상태
- 가루
- 색상
- 노란색
- 수소이온지수(pH)
- 7 (53g/l, H2O, 20℃)
- 수용성
- 녹는
- 감도
- Air Sensitive
- Merck
- 14,7368
- BRN
- 878317
- 노출 한도
- ACGIH: SL .025 mg/100 cm2; Ceiling 0.1 ppb (Skin)
- 안정성
- 안정적인. 공기에 민감합니다. 강한 산화제, 강한 염기와 호환되지 않습니다.
- InChIKey
- ZWLUXSQADUDCSB-UHFFFAOYSA-N
- LogP
- 0.99 at 30℃
- CAS 데이터베이스
- 643-79-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi,T,N,C | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38-43-34-25-50-52/53 | ||
안전지침서 | 26-28-36-45-36/37/39-61-37/39 | ||
유엔번호(UN No.) | UN2923 8/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | TH6950000 | ||
F 고인화성물질 | 1-8-10 | ||
자연 발화 온도 | 480 °C | ||
위험 참고 사항 | Irritant/Air Sensitive | ||
TSCA | Yes | ||
위험 등급 | 8 | ||
포장분류 | Ⅱ | ||
HS 번호 | 29122900 | ||
유해 물질 데이터 | 643-79-8(Hazardous Substances Data) | ||
독성 | LD50 orally in Rabbit: 178 mg/kg LD50 dermal Rat > 2000 mg/kg |
o-프탈알데히드 C화학적 특성, 용도, 생산
개요
황색 결정. 녹는점 56~57℃. 어느 것이든 물 및 대개의 유기 용매에 녹는다. 석유 에테르에 잘 안 녹는다. 수증기 증류할 수 있다. 산화크롬(Ⅵ)으로 산화하면 프탈산이 된다.화학적 성질
o-Phthalaldehyde is a pale yellow crystalline solid.o-Phthalaldehyde is mainly used as a high-level disinfectant (a low-temperature chemical method) for heat-sensitive medical and dental equipment such as endoscopes and thermometers; in recent years, it has gained popularity as a safe and better alternative to glutaraldehyde.
There are some researches show, pH7.5 contains the sterilizing agent of o-phthalaldehyde 0.5%, and its sterilizing power, sterilization speed, stability and toxicity all are better than glutaraldehyde, can kill mycobacterium in the 5min, the bacterium number reduces by 5 logarithmic value, and o-phthalaldehyde is very stable, tasteless in pH3~9 scopes, non-stimulated to human nose, eye mucosa, and need not activate before using, various materials are had good consistency, have tangible microbiocidal activity.
용도
o-Phthalaldehyde can be widely used for precolumn derivatization of amino acids in HPLC separation or Capillary electrophoresis. For flow cytometric measurements of protein thiol groups.정의
ChEBI: A dialdehyde in which two formyl groups are attached to adjacent carbon centres on a benzene ring.정의
Using o-phthalaldehyde (OPA) in combination with a thiol reagent is a standard method for detecting primary amines in amino acids, peptides, and proteins. O-phthalaldehyde, in the presence of 2-mercaptoethanol, reacts with primary amines to form highly fluorescent products. Picomole quantities of amino acids, peptides, and proteins can be detected easily. o-Phthalaldehyde is five to ten times more sensitive than fluorescamine and is soluble and stable in aqueous buffers. Despite its widespread use, the exact reaction mechanism has been debated since the 1980s. Rovelli's results support the mechanism originally proposed by Sternson and Wong, in which the primary amine first reacts with OPA, followed by a reaction with the thiol to form the fluorescent isoindole product[1-2].제조 방법
o-Phthalaldehyde is a high-level chemical disinfectant that is commonly used for disinfection of dental and medical instruments as an alternative to glutaraldehyde, which is a known skin and respiratory sensitizer.A variety of processes for manufacturing o-phthalaldehyde have been reported in the literature.
o-Phthalaldehyde is produced by heating pure benzaldehyde and chloroform with potassium hydroxide solution. The resulting solution is further acidified with hydrochloric acid and cooled to yield a colorless powder of o-phthalaldehyde.
It is also produced by ozonization of naphthalene in alcohol followed by catalytic hydrogenation.
Catalytic oxidation of various chemicals is also used in manufacturing o-phthalaldehyde. o-Phthalaldehyde can be manufactured by oxidation of phthalan by nitrogen monoxide in acetonitrile with N-hydroxyphthalimide as the catalyst to yield 80% to 90%.
Biotechnological Applications
O-phthalaldehyde(OPA) is used for precolumn derivatization of amino acids for HPLC separation and for flow cytometric measurements of protein thiol groups. Used for fluorometric determination of histamine, histidine and other amino acids. Also used for cholesterol assay in the picomole range.Phthaldialdehyde has been used:
in the preparation of O-phthaldialdehyde reagent for analysing gentamycin content.
in the preparation of reagent for determining the degree of hydrolysis of milk proteins.
in the measurement of free amino acids of milk samples by O-phthaldialdehyde/N-acetyl-L-cysteine (OPA/NAC) assay.
in the derivatization of putrescine samples.
잠재적 노출
The primary routes of human exposure to o-phthalaldehyde are by inhalation and through the skin, which may occur through accidental or occupational exposures. Along with its increasing popularity as a chemical sterilizer, o-phthalaldehyde has many applications in analytical methods and in diagnostic kits. o-Phthalaldehyde is also used as an intermediate in the synthesis of pharmaceuticals and as a reagent in the tanning industry, hair colorings, wood treatment, and antifouling paints. o-Phthalaldehyde was approved for use as an indoor antimicrobial pesticide in 1997; however, it is no longer registered with the United States Environmental Protection Agency (USEPA) for this use.Carcinogenicity
No information on the carcinogenicity of o-phthalaldehyde in experimental animals or humans was found in a review of the literature.o-프탈알데히드 준비 용품 및 원자재
원자재
준비 용품
o-프탈알데히드 공급 업체
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