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2-Chloropropionic acid

Description Preparation Application Biochemical Action Safety
2-Chloropropionic acid
2-Chloropropionic acid
Chemical Name:
2-Chloropropionic acid
NSC-173;NSC-401806;2-chloropropionic;2-Chlorpropionsure;RARECHEM AL BO 1240;2-Chloropropionic ac;-Chloropropanoicacid;2-chloro-propanoicaci;2-chloro-propionicaci;A-CHLOROPROPIONIC ACID
Molecular Formula:
Formula Weight:
MOL File:

2-Chloropropionic acid Properties

Melting point:
-12--14 °C
Boiling point:
170-190 °C(lit.)
1.182 g/mL at 25 °C(lit.)
vapor pressure 
4 mm Hg ( 20 °C)
refractive index 
n20/D 1.4345(lit.)
Flash point:
215 °F
storage temp. 
Store below +30°C.
H2O: soluble
<1 (200g/l, H2O, 20℃)
Water Solubility 
freely soluble
Stable. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference
598-78-7(CAS DataBase Reference)
NIST Chemistry Reference
Propanoic acid, 2-chloro-(598-78-7)
EPA Substance Registry System
Propanoic acid, 2-chloro-(598-78-7)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  C
Risk Statements  22-35-21/22
Safety Statements  23-26-28-36-45-36/37/39-28A
RIDADR  UN 2511 8/PG 3
WGK Germany  1
RTECS  UE8575000
HazardClass  8
PackingGroup  III
HS Code  29159080
Hazardous Substances Data 598-78-7(Hazardous Substances Data)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H310 Fatal in contact with skin Acute toxicity,dermal Category 1, 2 Danger P262, P264, P270, P280, P302+P350,P310, P322, P361, P363, P405, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H371 May cause damage to organs Specific target organ toxicity, single exposure Category 2 Warning P260, P264, P270, P309+P311, P405,P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P262 Do not get in eyes, on skin, or on clothing.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to..…

2-Chloropropionic acid price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 109274 2-Chloropropionic acid 92% 598-78-7 100g $30.8 2017-11-08 Buy
Sigma-Aldrich 109274 2-Chloropropionic acid 92% 598-78-7 500g $67.9 2017-11-08 Buy
TCI Chemical C0275 2-Chloropropionic Acid >98.0%(GC)(T) 598-78-7 25g $14 2017-11-08 Buy
TCI Chemical C0275 2-Chloropropionic Acid >98.0%(GC)(T) 598-78-7 500g $50 2017-11-08 Buy
Alfa Aesar A12860 (±)-2-Chloropropionic acid, 94% 598-78-7 500g $51.3 2017-11-08 Buy

2-Chloropropionic acid Chemical Properties,Uses,Production


2-Chloropropionic acid is a colorless to white crystalline solid or liquid that is denser than water; therefore, can sink and mix with water. It has a slight odor and is the simplest chiral chlorocarboxylic aid.


2-Chloropropionic acid is prepared from diazotization of L-alanine in hydrochloric acid.


2-Chloropropionic acid is employed in the production of propargyl 2-chloropropionate (PCP), which is an atom transfer radical polymerization (ATRP) initiator, by the esterification of propargyl alcohol.

The chemical is also used in the synthesis of benzimidazole derivatives when treated with o-phenylenediamine phosphate.

It can also be used in the preparation of biologically active chitin derivative (1-carboxyethyl) chitosan.

It is used as a building block for the preparation of herbicides, dyestuffs, pesticides, as well as forest- and agro-chemicals.

Biochemical Action

2-Chloropropionic acid induces necrosis of granule cell layer of rat cerebellum when administered orally.


2-Chloropropionic acid is a neurotoxin, as such it should be handled with utmost care. When inhaled, the chemical can irritate the nose, throat, and lungs, causing wheezing and coughing.

The chemical is a corrosive substance, which may occur by ingestion. Contact of the chemical with the eyes and skin may cause pain, irritation, redness, and severe burns.

Chemical Properties

colourless liquid

General Description

A pale liquid with a slight odor. Sinks in and mixes with water. Only aluminum, stainless steel or steel covered with a protective lining or coating may contact the liquid or vapor.

Air & Water Reactions

Water soluble.

Reactivity Profile

2-Chloropropionic acid is neutralized in exothermic reactions by all bases. Reacts with aqueous solutions containing a chemical base and dissolves if neutralization generates a soluble salt. May react with active metals to form gaseous hydrogen and a metal salt. May corrode or dissolve iron, steel, and aluminum parts and containers. Reacts with cyanide salts to generate gaseous hydrogen cyanide. Reacts with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides to generate flammable and/or toxic gases and heat. Reacts with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Reacts with carbonates and bicarbonates to generate a harmless gas (carbon dioxide) but some heat. Can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. May initiate polymerization reactions or catalyze other chemical reactions. Fire produces highly toxic chloride fumes [USCG, 1999].

Health Hazard

Harmful if inhaled. Irritating to throat. May cause severe skin and eye burns. Harmful if absorbed through skin.

Purification Methods

Dry it with P2O5 and fractionally distil it under vacuum. [Beilstein 2 IV 745.]

2-Chloropropionic acid Preparation Products And Raw materials

Raw materials

Preparation Products

2-Chloropropionic acid Suppliers

Global( 161)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32765 55
career henan chemical co
+86-371-86658258 CHINA 10012 58
13867897135 CHINA 931 58
Shanghai ideal Industrial Co., Ltd. 021-60899019
021-60899437 China 2931 58
Changzhou Liren Medical Technology Co. Ltd. 0519-85859058 CHINA 164 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96815 76
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 China 30308 84
TCI (Shanghai) Development Co., Ltd. 800-988-0390
021-67121385 China 22909 81
BeiJing Hwrk Chemicals Limted 4006990298;010-57411839;0757-86311057;021-51691807
010-87653215;0757-86311057;021-55236763 China 14687 55
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 China 44192 61

View Lastest Price from 2-Chloropropionic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-06 2-Chloropropionic acid
US $1.00 / KG 1KG 98% 1

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