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2-Chloropropionic acid

Chemical Name:
2-Chloropropionic acid
2-Chloropropionoic acid;2-chloroproprionic acid;NSC-173;NSC-401806;2-chloropropionic;2-Chlorpropionsure;RARECHEM AL BO 1240;2-Chloropropionic ac;-Chloropropanoicacid;2-chloro-propanoicaci
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
MSDS File:
Last updated:2023-08-24 17:20:48

2-Chloropropionic acid Properties

Melting point -12--14 °C
Boiling point 170-190 °C(lit.)
Density 1.182 g/mL at 25 °C(lit.)
vapor pressure 4 mm Hg ( 20 °C)
refractive index n20/D 1.4345(lit.)
Flash point 215 °F
storage temp. Store below +30°C.
solubility H2O: soluble
pka 2.96±0.10(Predicted)
form clear liquid
color Colorless to Almost colorless
PH <1 (200g/l, H2O, 20℃)
Water Solubility freely soluble
BRN 1720259
Exposure limits ACGIH: TWA 0.1 ppm (Skin)
Stability Stable. Incompatible with strong oxidizing agents, strong bases.
LogP 0.82 at 20.5℃
CAS DataBase Reference 598-78-7(CAS DataBase Reference)
EWG's Food Scores 1-2
Proposition 65 List 2-Chloropropionic Acid
NIST Chemistry Reference Propanoic acid, 2-chloro-(598-78-7)
EPA Substance Registry System 2-Chloropropionic acid (598-78-7)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
Signal word  Danger
Hazard statements  H302-H314
Precautionary statements  P260-P280-P301+P312+P330-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  C
Risk Statements  22-35-21/22
Safety Statements  23-26-28-36-45-36/37/39-28A
RIDADR  UN 2511 8/PG 3
WGK Germany  1
RTECS  UE8575000
HazardClass  8
PackingGroup  III
HS Code  29159080
NFPA 704
3 0

2-Chloropropionic acid price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 109274 2-Chloropropionic acid 92% 598-78-7 100g $37.9 2023-06-20 Buy
Sigma-Aldrich 109274 2-Chloropropionic acid 92% 598-78-7 500g $85 2023-06-20 Buy
TCI Chemical C0275 2-Chloropropionic Acid >98.0%(GC)(T) 598-78-7 25g $23 2023-06-20 Buy
TCI Chemical C0275 2-Chloropropionic Acid >98.0%(GC)(T) 598-78-7 500g $81 2023-06-20 Buy
Alfa Aesar A12860 (±)-2-Chloropropionic acid, 94% 598-78-7 100g $24.7 2023-06-20 Buy
Product number Packaging Price Buy
109274 100g $37.9 Buy
109274 500g $85 Buy
C0275 25g $23 Buy
C0275 500g $81 Buy
A12860 100g $24.7 Buy

2-Chloropropionic acid Chemical Properties,Uses,Production


2-Chloropropionic acid is a colorless to white crystalline solid or liquid that is denser than water; therefore, can sink and mix with water. It has a slight odor and is the simplest chiral chlorocarboxylic aid.


2-Chloropropionic acid is prepared from diazotization of L-alanine in hydrochloric acid.


2-Chloropropionic acid is employed in the production of propargyl 2-chloropropionate (PCP), which is an atom transfer radical polymerization (ATRP) initiator, by the esterification of propargyl alcohol.

The chemical is also used in the synthesis of benzimidazole derivatives when treated with o-phenylenediamine phosphate.

It can also be used in the preparation of biologically active chitin derivative (1-carboxyethyl) chitosan.

It is used as a building block for the preparation of herbicides, dyestuffs, pesticides, as well as forestand agro-chemicals.

Biochemical Action

2-Chloropropionic acid induces necrosis of granule cell layer of rat cerebellum when administered orally.


2-Chloropropionic acid is a neurotoxin, as such it should be handled with utmost care. When inhaled, the chemical can irritate the nose, throat, and lungs, causing wheezing and coughing.

The chemical is a corrosive substance, which may occur by ingestion. Contact of the chemical with the eyes and skin may cause pain, irritation, redness, and severe burns.

Chemical Properties

colourless liquid


  • 2-Chloropropionic acid is used in the preparation of propargyl 2-chloropropionate (PCP), an atom transfer radical polymerization (ATRP) initiator, by the esterification of propargyl alcohol.
  • It can be employed in the synthesis of a biologically active chitin derivative, (1-carboxyethyl) chitosan.
  • It can be treated with o-phenylenediamine phosphate to synthesize benzimidazole derivatives.


Intermediate for weed killers.

General Description

A pale liquid with a slight odor. Sinks in and mixes with water. Only aluminum, stainless steel or steel covered with a protective lining or coating may contact the liquid or vapor.

Air & Water Reactions

Water soluble.

Reactivity Profile

2-Chloropropionic acid is neutralized in exothermic reactions by all bases. Reacts with aqueous solutions containing a chemical base and dissolves if neutralization generates a soluble salt. May react with active metals to form gaseous hydrogen and a metal salt. May corrode or dissolve iron, steel, and aluminum parts and containers. Reacts with cyanide salts to generate gaseous hydrogen cyanide. Reacts with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides to generate flammable and/or toxic gases and heat. Reacts with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Reacts with carbonates and bicarbonates to generate a harmless gas (carbon dioxide) but some heat. Can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. May initiate polymerization reactions or catalyze other chemical reactions. Fire produces highly toxic chloride fumes [USCG, 1999].


Combustible. Toxic by skin contact. Male reproductive damage.

Health Hazard

Harmful if inhaled. Irritating to throat. May cause severe skin and eye burns. Harmful if absorbed through skin.

Flammability and Explosibility

Non flammable

Biochem/physiol Actions

2-Chloropropionic acid on oral administration induces necrosis of granule cell layer of rat cerebellum.

Safety Profile

Poison by skin contact. A corrosive. Combustible when exposed to heat or flame. To fight fire, use water, foam, alcohol foam. When heated to decomposition it emits toxic fumes of Cl-. See also 3-CHLOROPROPIONIC ACID.

Purification Methods

Dry it with P2O5 and fractionally distil it under vacuum. [Beilstein 2 IV 745.]

Synthesis of 2-Chloropropionic acid from L(+)-Lactic acid
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View Lastest Price from 2-Chloropropionic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloropropionic acid pictures 2023-08-24 2-Chloropropionic acid
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
2-Chloropropionic acid pictures 2021-10-14 2-Chloropropionic acid
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2-Chloropropionic acid pictures 2021-07-02 2-Chloropropionic acid
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
ALPHA-CHLOROPROPIONIC ACID 2-CHLOROPROPIONIC ACID pract (±)-2-Chloropropionicacid,97% A-CHLOROPROPIONIC ACID Propanoic acid, 2-chloro- (n)-2-chloropropionic acid MONO-CHLOROPROPANOICACID 2-Chlorpropionsure 2-CHLOROPROPIONIC ACID (92%) 2-Chloropropionic acid,95% 2-Chloropropionic ac NSC-173 NSC-401806 2-Chloropropionic acid, 95% 500ML 2-CHLOROPROPIONIC ACID FOR SYNTHESIS alpha-monochloropropionicacid -Chloropropanoicacid Propionic acid, 2-chloro- Propionic acid, alpha-chloro- RARECHEM AL BO 1240 (+/-)-2-CHLOROPROPIONIC ACID 2-CHLOROPROPIONIC ACID (R,S)-2-Chloro-propionicacid 2-chloro-propanoicaci 2-chloropropionic 2-chloro-propionicaci alpha-chloro-propionicaci alpha-Monochloropropionic acid Beta 2-Chloro Propionic Acid 2-chlropropionic acid 2-Chloropropionic Acid > 2-Chloropropionic acid ISO 9001:2015 REACH 2-Chloropropionic acid, puriss, 98% 2-Chloropropionic Acid pure, 97% 2-Chloropropionoic acid 2-chloroproprionic acid *Ethyl Acetate Impurity 14 (Ethyl Propionate) 598-78-7 520-01-7 CH3CHClCOOH CARBOXYLIC ACID Organic Building Blocks Building Blocks C1 to C5 Carbonyl Compounds Carboxylic Acids API Intermediate C1 to C5 Carbonyl Compounds Carboxylic Acids Organic acids