Ethyl trifluoromethanesulfonate
- CAS No.
- 425-75-2
- Chemical Name:
- Ethyl trifluoromethanesulfonate
- Synonyms
- ETHYL TRIFLATE;Ethyl trifluoromethanesulf;Ethyltrifluormethansulfonat;Ethyl trifluoromethanesulfote;Ethyl trifluoromethesulfonate;ETHYL TRIFLUROMETHANSULFONATE;Ethyl trifluoroMethanesulfonat;Ethyl trifluoromethylsulfonate;ETHYL TRIFLUOROMETHANESULFONATE;ETHYL TRIFLURO METHANESULFONATE
- CBNumber:
- CB4332659
- Molecular Formula:
- C3H5F3O3S
- Molecular Weight:
- 178.13
- MDL Number:
- MFCD00000410
- MOL File:
- 425-75-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Ethyl trifluoromethanesulfonate 99% | 246530 | 1g | $41.2 |
| Ethyl trifluoromethanesulfonate 99% | 246530 | 5g | $63.2 |
| Ethyl Trifluoromethanesulfonate >98.0%(GC) | T1191 | 5g | $30 |
| Ethyl Trifluoromethanesulfonate >98.0%(GC) | T1191 | 25g | $104 |
| Ethyl trifluoromethanesulfonate 99% | 246530 | 25g | $206 |
| More product size | |||
| Boiling point | 115 °C (lit.) |
|---|---|
| Density | 1.374 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 96 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform, Methanol (Slightly) |
| form | Oil |
| color | Colourless |
| Specific Gravity | 1.374 |
| Water Solubility | Hydrolyzes in water. |
| Sensitive | Hygroscopic |
| BRN | 1770746 |
| Stability | Volatile |
| InChI | 1S/C3H5F3O3S/c1-2-9-10(7,8)3(4,5)6/h2H2,1H3 |
| InChIKey | UVECLJDRPFNRRQ-UHFFFAOYSA-N |
| SMILES | CCOS(=O)(=O)C(F)(F)F |
| CAS DataBase Reference | 425-75-2(CAS DataBase Reference) |
| EPA Substance Registry System | Methanesulfonic acid, trifluoro-, ethyl ester (425-75-2) |
| UNSPSC Code | 12352108 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H314 | |||||||||
| Precautionary statements | P210-P233-P240-P280-P303+P361+P353-P305+P351+P338 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | C,T,F | |||||||||
| Risk Statements | 10-34 | |||||||||
| Safety Statements | 16-26-36/37/39-45 | |||||||||
| RIDADR | UN 2920 8/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| F | 3 | |||||||||
| Hazard Note | Highly Toxic | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29049090 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Flam. Liq. 3 Skin Corr. 1B |
|||||||||
| Limited Quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
Ethyl trifluoromethanesulfonate price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 246530 | Ethyl trifluoromethanesulfonate 99% | 425-75-2 | 1g | $41.2 | 2026-03-19 | Buy |
| Sigma-Aldrich | 246530 | Ethyl trifluoromethanesulfonate 99% | 425-75-2 | 5g | $63.2 | 2026-03-19 | Buy |
| TCI Chemical | T1191 | Ethyl Trifluoromethanesulfonate >98.0%(GC) | 425-75-2 | 5g | $30 | 2026-03-19 | Buy |
| TCI Chemical | T1191 | Ethyl Trifluoromethanesulfonate >98.0%(GC) | 425-75-2 | 25g | $104 | 2026-03-19 | Buy |
| Sigma-Aldrich | 246530 | Ethyl trifluoromethanesulfonate 99% | 425-75-2 | 25g | $206 | 2026-03-19 | Buy |
Ethyl trifluoromethanesulfonate Chemical Properties,Uses,Production
Description
Ethyl trifluoromethanesulfonate is a cationic polymerization agent used to produce polyurethane, polyacrylate, and other synthetic resins. It is an effective drug for the treatment of HIV infection and chronic bronchitis. Ethyl trifluoromethanesulfonate has been shown to inhibit the replication of HIV-1 virus at concentrations as low as 1 μM when tested in vitro. The mechanism of this drug's anti-HIV activity is unknown and may involve the inhibition of reverse transcriptase or proteases. Ethyl trifluoromethanesulfonate can be detected in vivo up to 4 hours after administration. This drug is metabolized into trifluoroacetic acid by esterases, glycosidases, and/or oxidases.
Chemical Properties
Clear colorless to yellow liquid
Uses
Ethyl trifluoromethanesulfonate is a powerful ethylating agent. due to the strong electron-absorbing ability of trifluoromethanesulfonyl, the reactivity is much higher than that of conventional alkylation reagents such as bichloride or alkyl sulfonate.
Synthesis
Triethyl orthoformate (4.44g,30mmol) was slowly added to trifluoromethanesulfonic anhydride (8.47g,30mmol) under ice bath, transferred to 25°C for reaction, monitored by NMR for 15 min, and the reaction was completed, distilled under reduced pressure to obtain 10.15g of ethyl trifluoromethanesulfonate colorless liquid in 94% yield.
Purification Methods
The ester reacts slowly with H2O and aqueous alkali. If its IR has no OH bands (~3000 cm-1) then purify it by redistillation. If OH bands are present, then dilute with dry Et2O and shake (carefully) with aqueous NaHCO3 until effervescence ceases, then wash with H2O and dry (MgSO4), filter, evaporate and distil the residue under a slight vacuum then at atmospheric pressure in a N2 atmosphere. IT IS A POWERFUL ALKYLATING AGENT, AND THE FUMES ARE VERY TOXIC — PERFORM ALL OPERATIONS IN AN EFFICIENT FUME CUPBOARD. [Gramstad & Haszeldine J Chem Soc 173 1956, Howells & McCown Chem Rev 77 69 1977, Beilstein 3 IV 34.]
Ethyl trifluoromethanesulfonate Preparation Products And Raw materials
Raw materials
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Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| JIANGXI TIME PHARMACEUTICAL CO.,LTD | +86-0794-7183888 +86-13155888520 | sales@groupchem.com | China | 27 | 58 |
| LY Global chemicals co.,ltd . | +8618939937369 | info@lychems.cn | China | 969 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-18712993135 | sales01@tairunfaz.com | China | 8051 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13843 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21591 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
View Lastest Price from Ethyl trifluoromethanesulfonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-29 | Ethyl trifluoromethanesulfonate
425-75-2
|
US $5.00 / kg | 1kg | ≥99% | 200mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2026-04-17 | Ethyl triflate
425-75-2
|
US $2.00-5.00 / kg | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2025-06-27 | Ethyl trifluoromethanesulfonate
425-75-2
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Ethyl trifluoromethanesulfonate
425-75-2
- US $5.00 / kg
- ≥99%
- Jinan Finer Chemical Co., Ltd
-
- Ethyl triflate
425-75-2
- US $2.00-5.00 / kg
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- Ethyl trifluoromethanesulfonate
425-75-2
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
