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Osthole

Plant extracts Physical and Chemical Properties Pharmacological effects Botanical insecticides
Osthole
Osthole structure
CAS No.
484-12-8
Chemical Name:
Osthole
Synonyms
Ostol;OSTHOL;Ostole;Cnidium;OSTHOLE;NSC 31868;OSTHOLE(P);AKOS 236-34;Osthole, CP;Damiana p.e
CBNumber:
CB7454402
Molecular Formula:
C15H16O3
Formula Weight:
244.29
MOL File:
484-12-8.mol

Osthole Properties

Melting point:
83-84°C
Boiling point:
347.2°C (rough estimate)
Density 
1.1263 (rough estimate)
refractive index 
1.5570 (estimate)
storage temp. 
room temp
solubility 
methanol: soluble10mg/mL, clear, colorless
form 
powder
color 
white
λmax
322nm(MeOH)(lit.)
Merck 
14,6895
InChIKey
MBRLOUHOWLUMFF-UHFFFAOYSA-N
CAS DataBase Reference
484-12-8(CAS DataBase Reference)
NIST Chemistry Reference
Osthole(484-12-8)
SAFETY
  • Risk and Safety Statements
WGK Germany  3
RTECS  GN7700000
HS Code  29322090

Osthole price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 78889 Osthole analytical standard 484-12-8 25mg $269 2019-12-02 Buy
Sigma-Aldrich 02150595 Osthole primary pharmaceutical reference standard 484-12-8 10mg $121 2019-12-02 Buy
TCI Chemical O0426 Osthole >98.0%(GC) 484-12-8 250mg $76 2019-12-02 Buy
TCI Chemical O0426 Osthole >98.0%(GC) 484-12-8 1g $227 2019-12-02 Buy
Cayman Chemical 19195 Osthole ≥98% 484-12-8 1g $112 2018-11-13 Buy

Osthole Chemical Properties,Uses,Production

Plant extracts

Osthole is a substance extracted from the fruit of the annual Umbelliferae plant Fructus Cnidii. It appears as yellow-green to white crystalline powder. It is insoluble in cold water and petroleum ether, easily soluble in acetone, methanol, ethanol, chloroform and ethyl acetate and soluble in boiling petroleum ether. It has various effects including antispasmodic, hypotensive, anti-arrhythmic, enhancing immune function and broad-spectrum antimicrobial effect. It is clinically mainly used for the treatment of men impotence, scrotal wet itchy, women prurUus Yulvae and cold uterus and infertility, rheumatism, scabies, eczema and trichomonas vaginitis. Osthole can also be used to make field insecticides, fungicides with contact killing action being the primary effect and stomach poisoning being the auxiliary effect. The drug liquid can be absorbed through body surface and enter into the body and further act on the nervous system of pests, causing the non-functional muscle contraction of the pests and eventually leading to death due to energy exhaustion. It has a relative excellent contact-killing effect on various kinds of pests such as cabbage caterpillar, tea looper, cotton bollworm, beet armyworm and any kinds of aphids.

Physical and Chemical Properties

Osthole belongs to coumarin compounds. It is prismatic-like crystals (diethyl ether) and needle-like crystals (Ethanol) with the melting point being 83~84 ℃ and the boiling point being 145~150 ℃. It is soluble in alkaline solution, methanol, ethanol, chloroform, acetone, ethyl acetate, and boiling petroleum ether but insoluble in water and petroleum ether.

Pharmacological effects

Osthole has various kinds of effects of antispasmodic, hypotensive, anti-arrhythmic and enhancing immune function and broad-spectrum antimicrobial effect. Osthole can not only have efficacy such as anti-hypertensive, anti-arrhythmic, anti-inflammatory, anti-tumor and anti-osteoporosis effect, but can also act as a new type of biological pesticides with significant efficacy in treating pests and plant pathogens.
The above information is edited by the chemicalbook of Dai Xiongfeng.

Botanical insecticides

Osthole is a class of natural coumarin compound which had been initially extracted from Umbelliferae plants. The dried ripe fruit of Fructus Cnidii in the Umbelliferae plant, Cnidium monnieri has a relative high content, hence obtaining the name. Related research has shown that Osthole is also presented in other kinds of plants, including Umbelliferae including Angelica, Archangelica Hoffm and Cnidium as well as rutaceous plant such as citrus, clausena, Limonia acidissima and Haplophyllum A. Juss. In addition, it is also distributed in a few species of Asteraceae and legumes.
Osthole has its chemical name being 7-methoxy-8-isopenteylcoumarin with the core structure consisting of benzene and pyrone ring. As a member of coumarins compounds, Osthole, in addition to containing the core structure of coumarin, also has isopentenyl structure. Compound containing isopentenyl structure, as a phytoalexin, plays an important role in fighting against disease.
Osthole, as a kind of botanical pesticide, has contact-killing effect being the primary effect and stomach poisoning effect being the auxiliary effect. The drug liquid can be absorbed into the insect body through body surface and acts on the nervous system of pests, causing non-functional muscle contraction and final death due to energy exhaustion. Indoor activity virulence tests have showed that it has a higher activity against Pieris rapae (LD50 is 6.2258 mg/kg). It is demonstrated through the field efficacy trials that it has excellent efficacy in the treatment of Pieris rapae of cruciferous vegetables and tea and tea looper caterpillar. The drug dosage for prevention and treatment of the Pieris rapae of cruciferous vegetables has the active ingredient be 4.8~7.2g/hm (equals to 80~120 mL per acre if converted to 0.4% Osthole cream commercialized product); the drug dosage against tea mites has the active ingredient be 6 to 7.2 g/hm (equals to 100~120 mL per acre if converted to 0.4% Osthole cream commercialized product). Apply the drug liquid at an amount of 50~75 kg per acre with uniform spray; the period of validity is about 7d. It is safe for crop within the dose range with no drug injury.

Definition

ChEBI: A natural product found in Peucedanum ostruthium and Angelica pubescens.

Osthole Preparation Products And Raw materials

Raw materials

Preparation Products


Osthole Suppliers

Global( 282)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Standard Technology Co., Ltd.
18502101150
+86-21-57127007-6606 ft-sales@nature-standard.com CHINA 570 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21686 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32447 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 570 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29996 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2368 58

View Lastest Price from Osthole manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-10-15 Osthole
484-12-8
US $0.00 / mg 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
2019-10-15 Osthole
484-12-8
US $0.00 / mg 5mg Analytical Standard 10 g Shanghai Standard Technology Co., Ltd.
2019-07-16 Osthole 484-12-8
484-12-8
US $25.00 / g 1g ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.

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