2-Cyclohexylmandelic acid
- CAS No.
- 4335-77-7
- Chemical Name:
- 2-Cyclohexylmandelic acid
- Synonyms
- rcc32;kl-007-m1;lespedamine;-2-hydroxy-phenyL;CYCLOHEXYLMANDELIC;TIMTEC-BB SBB008619;hexahydrobenzilicacid;Oxybutynin Impurity D;2-Cyclohexylmennic acid;CYCLOHEXYL MANDELIC ACID
- CBNumber:
- CB7472035
- Molecular Formula:
- C14H18O3
- Molecular Weight:
- 234.29
- MDL Number:
- MFCD00194543
- MOL File:
- 4335-77-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Oxybutynin Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material | PHR2548 | 200 mg | $777 |
| Phenylcyclohexylglycolic acid British Pharmacopoeia (BP) Reference Standard | BP703 | 25MG | $292 |
| α-Cyclohexylmandelic acid 97% | 706418 | 5g | $63.7 |
| Oxybutynin Related Compound A United States Pharmacopeia (USP) Reference Standard | 1485114 | 100mg | $1390 |
| alpha-Cyclohexyl-DL-mandelic Acid >98.0%(HPLC)(T) | C2393 | 5g | $70 |
| More product size | |||
| Melting point | 163 °C |
|---|---|
| Boiling point | 135℃/3mm |
| Density | 1.206±0.06 g/cm3(Predicted) |
| RTECS | GV2770000 |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Methanol (Sparingly) |
| form | Solid |
| pka | 3.49±0.25(Predicted) |
| color | White to pale brown |
| InChI | 1S/C14H18O3/c15-13(16)14(17,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1,3-4,7-8,12,17H,2,5-6,9-10H2,(H,15,16) |
| InChIKey | YTRNSQPXEDGWMR-UHFFFAOYSA-N |
| SMILES | OC(=O)C(O)(C1CCCCC1)c2ccccc2 |
| CAS DataBase Reference | 4335-77-7(CAS DataBase Reference) |
| FDA UNII | QH762W903U |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318-H335 | |||||||||
| Precautionary statements | P261-P264-P280-P280-P304+P340+P312-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 37/38-41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29181990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Cyclohexylmandelic acid price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2548 | Oxybutynin Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material | 4335-77-7 | 200 mg | $777 | 2026-04-30 | Buy |
| Sigma-Aldrich | BP703 | Phenylcyclohexylglycolic acid British Pharmacopoeia (BP) Reference Standard | 4335-77-7 | 25MG | $292 | 2026-04-30 | Buy |
| Sigma-Aldrich | 706418 | α-Cyclohexylmandelic acid 97% | 4335-77-7 | 5g | $63.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1485114 | Oxybutynin Related Compound A United States Pharmacopeia (USP) Reference Standard | 4335-77-7 | 100mg | $1390 | 2026-04-30 | Buy |
| TCI Chemical | C2393 | alpha-Cyclohexyl-DL-mandelic Acid >98.0%(HPLC)(T) | 4335-77-7 | 5g | $70 | 2026-04-30 | Buy |
2-Cyclohexylmandelic acid Chemical Properties,Uses,Production
Description
This indole alkaloid occurs in the leaves of Lespedeza bicolor var. japonica and, when pure, is a colourless oil. Its MeOH solution, the ultraviolet spectrum exhibits absorption maxima at 223.4, 279 and 291 mJi. The crystalline hydrochloride has m.p. 163-4°C (dec.); the picrate forms long, yellow needles from MeOH, m.p. 160-2°C (dec.) and the styphnate, also yellow needles, has m.p. 170°C (dec.). The structure has been established as 3-(dimethylaminoethyl)-1-methoxyindole.
Chemical Properties
White Solid
Uses
intermediate for Oxybutynin HCl, Oxyphenonium Bromide
Uses
An intermediate in the synthesis of oxybutynin (O868525). Oxybutynin USP Related Compound A.
Definition
ChEBI: Alpha-Cyclohexylmandelic acid is a member of benzenes.
Synthesis
31197-69-0
4335-77-7
General procedure for the synthesis of 2-cyclohexyl-2-hydroxyphenylacetic acid from oxybutynin impurity 2: To a solution of methanol (20 mL) containing cyclohexyl-hydroxy-phenylacetic acid (1.04 g, 3.96 mmol) was added a 1N NaOH solution (8 mL). The reaction mixture was heated to 80 °C and stirred continuously for 3.5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently extracted with ether. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and finally concentrated under reduced pressure to give the crude product as a white solid. Purification of the crude product by recrystallization from a solvent mixture of hexane and dichloromethane afforded 900 mg of 2-cyclohexyl-2-hydroxyphenylacetic acid in 97% yield. The structure of the product was confirmed by 1H-NMR (CDCl3).
References
Morimoto, Oshio., Annalen, 682, 212 (1965)
2-Cyclohexylmandelic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2176 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Changzhou Carman Chemical Co., Ltd. | 15061933924 | CHINA | 514 | 58 | |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| zhangjiagang vinsce bio-pharm. limited. | 86-512-58389969 | sales1@swellxin.com | CHINA | 111 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
View Lastest Price from 2-Cyclohexylmandelic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-26 | 2-Cyclohexylmandelic Acid
4335-77-7
|
US $8.70 / KG | 10KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2025-04-04 | 2-Cyclohexylmandelic acid
4335-77-7
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2019-07-06 | 2-Cyclohexylmandelic acid
4335-77-7
|
US $8.00 / kg | 1kg | 99% | 10MT | Career Henan Chemical Co |
-
- 2-Cyclohexylmandelic Acid
4335-77-7
- US $8.70 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 2-Cyclohexylmandelic acid
4335-77-7
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2-Cyclohexylmandelic acid
4335-77-7
- US $8.00 / kg
- 99%
- Career Henan Chemical Co
