ML417
- CAS No.
- 1386162-69-1
- Chemical Name:
- ML417
- Synonyms
- ML417;ML417, 10 mM in DMSO;2-{4-[2-(4-methoxyphenoxy)ethyl]piperazine-1-carbonyl}-1H-indole;(1H-indol-2-yl)(4-(2-(4-methoxyphenoxy)ethyl)piperazin-1-yl)methanone;Methanone, 1H-indol-2-yl[4-[2-(4-methoxyphenoxy)ethyl]-1-piperazinyl]-;neuroprotection,dopaminergic,β-arrestin,ML417,ML-417,translocation,phosphorylation,neurons,ML 417,Inhibitor,Dopamine Receptor,inhibit
- CBNumber:
- CB76183003
- Molecular Formula:
- C22H25N3O3
- Molecular Weight:
- 379.45
- MDL Number:
- MFCD32693923
- MOL File:
- 1386162-69-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 613.3±55.0 °C(Predicted) |
|---|---|
| Density | 1.231±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 2mg/mL, clear |
| form | Solid |
| pka | 16.11±0.30(Predicted) |
| color | Off-white to light yellow |
| InChIKey | HAZPAMUWUHDPDA-UHFFFAOYSA-N |
| SMILES | N2(CCN(CC2)C(=O)c3[nH]c4c(c3)cccc4)CCOc1ccc(cc1)OC |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
ML417 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 36582 | ML-417 ≥98% | 1386162-69-1 | 5mg | $83 | 2026-04-30 | Buy |
| Cayman Chemical | 36582 | ML-417 ≥98% | 1386162-69-1 | 10mg | $157 | 2026-04-30 | Buy |
| Cayman Chemical | 36582 | ML-417 ≥98% | 1386162-69-1 | 25mg | $370 | 2026-04-30 | Buy |
| Biosynth | LFC16269 | ML417 | 1386162-69-1 | 50mg | $1034.5 | 2026-06-04 | Buy |
| Biosynth | LFC16269 | ML417 | 1386162-69-1 | 100mg | $1440 | 2026-06-04 | Buy |
ML417 Chemical Properties, Uses, Production
Uses
ML417 is a selective and brain penetrant D3 dopamine receptor (D3R) agonist, with an EC50 of 38 nM. ML417 potently promotes D3R-mediated β-arrestin translocation, G protein mediated signaling, and pERK phosphorylation with minimal effects on other GPCR-mediated signaling. ML417 exhibits neuroprotection against toxin-induced neurodegeneration of dopaminergic neurons[1].
Biological Activity
ML417 is a blood-brain barrier permeable, potent and highly selective agonist of D3 dopamine receptor (D3R) with very limited cross-reactivity at other GPCRs. ML417 potently induces G-protein activation, D3R-mediated b-arrestin translocation and pERK phosphorylation. It does not activate other dopamine receptors. ML417 protect D3R-expressing dopaminergic neurons from 6-OHDA induced cell death.
in vivo
In vivo pharmacokinetics experiments in mice (using 20 mg/kg; i.p.) reveals that ML417 is brain penetrant and exhibits a plasma half-life of 3.44 hours and a brain half-life of 4.23 hours. ML417 displays a plasma Tmax of 0.5 hours and Cmax of 6500 ng/ml, and a brain Tmax of 0.25 hours and Cmax of 28000 ng/ml[1].
| Animal Model: | 6-8 week old male C57BL/6 mice[1] |
| Dosage: | 20 mg/kg |
| Administration: | I.p. (Pharmacokinetic Analysis) |
| Result: | Brain penetrant and exhibits a plasma half-life of 3.44 hours and a brain half-life of 4.23 hours. Displayed a plasma Tmax of 0.5 hours and Cmax of 6500 ng/ml, and a brain Tmax of 0.25 hours and Cmax of 28000 ng/ml. |
IC 50
D3 Receptor: 38 nM (EC50)
References
[1] Moritz AE, et al. Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist. J Med Chem. 2020;63(10):5526‐5567. DOI:10.1021/acs.jmedchem.0c00424
ML417 Preparation Products And Raw materials
Raw materials
Preparation Products
ML417 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4865 | 55 | |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2996 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 18916372613 | yanzihan@shyuanye.com | China | 87240 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 7998 | 62 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2962 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9765 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28149 | 68 |
| Twochem Co.Ltd. | 021-58111628 15800915896 | sales@twochem.com | China | 1782 | 58 |
