Atrasentan hydrochloride
- CAS No.
- 195733-43-8
- Chemical Name:
- Atrasentan hydrochloride
- Synonyms
- ABT627;ABT-627;ABT 627;A 147627.1;Abbott 147627;Atrasentan HCl;Unii-E4G31X93za;ABT-627 hydrochloride;A-147627 hydrochloride;Atrasentan hydrochloride
- CBNumber:
- CB82128704
- Molecular Formula:
- C29H38N2O6.HCl
- Molecular Weight:
- 547.08
- MDL Number:
- MFCD13194884
- MOL File:
- 195733-43-8.mol
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
|---|---|
| solubility | Soluble in DMSO |
| form | Powder |
| InChIKey | IJFUJIFSUKPWCZ-FZVADPAUNA-N |
| SMILES | C1(=CC2=C(OCO2)C=C1)[C@@H]1[C@@H](C(=O)O)[C@H](C2C=CC(OC)=CC=2)N(CC(N(CCCC)CCCC)=O)C1.Cl |&1:9,10,14,r| |
| FDA UNII | E4G31X93ZA |
| NCI Drug Dictionary | atrasentan hydrochloride |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
Atrasentan hydrochloride price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A793930 | AtrasentanHydrochloride | 195733-43-8 | 25mg | $825 | 2021-12-16 | Buy |
| AK Scientific | 0895CB | Atrasentanhydrochloride | 195733-43-8 | 50mg | $937 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA64949 | Atrasentan hydrochloride | 195733-43-8 | 100mg | $1010 | 2021-12-16 | Buy |
| ChemScene | CS-1373 | Atrasentan(hydrochloride) 99.51% | 195733-43-8 | 50mg | $1087 | 2021-12-16 | Buy |
| AK Scientific | 0895CB | Atrasentanhydrochloride | 195733-43-8 | 5mg | $277 | 2021-12-16 | Buy |
Atrasentan hydrochloride Chemical Properties,Uses,Production
Description
Atrasentan Hydrochloride is the orally available hydrochloride salt of pyrrolidine-3-carboxylic acid with potential antineoplastic activity. As a selective antagonist of the endothelin-A (ETA) receptor, atrasentan binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation.
Uses
Atrasentan belongs to a pyrrolidine and benzodioxole derivative. It is a selective antagonist of the endothelin-A (ETA) receptor and binds selectively to the ETA receptor, which may result in the inhibition of endothelin-induced angiogenesis and tumor cell proliferation. Its potential therapeutic uses include the treatment of diabetic nephropathies and as an antineoplastic agent.
Biological Activity
Atrasentan is a selective endothelin ETA receptor antagonist with an IC50 of 0.2 nM for ETA compared to 190 nM for ETB receptors. It blocks blocks endothelin induced cell proliferation, and has been investigated as a possible treatment for prostate cancer, and more recently for therapy for diabetic kidney disease.
Atrasentan hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Atrasentan hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Xi'an ZB Biotech Co.,Ltd | sales03@xazbbio.com | CHINA | 722 | 58 | |
| Wuhan Ruilida Biomedical Technology Co., Ltd. | 18201884268 | magean83@163.com | China | 1283 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |