1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy
![1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy Structure](CAS/20150408/GIF/145317-11-9.gif)
- CAS No.
- 145317-11-9
- Chemical Name:
- 1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy
- Synonyms
- BIM X;BIM-X hydrochloride;Ro 31-8425 Ro 31-8425;Bisindoylmaleimide X HCl;BIM X;RO 31-8425RO 31-8425;Bisindoylmaleimide X hydrochloride ≥95%;Bisindoylmaleimide X (Ro 31-8425);BISINDOLYLMALEIMIDE X HYDROCHLORIDE (BIM-X HYDROCHLORIDE);3-[8-(aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy
- CBNumber:
- CB82667395
- Molecular Formula:
- C26H25ClN4O2
- Molecular Weight:
- 460.96
- MDL Number:
- MOL File:
- 145317-11-9.mol
1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy Properties
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
|---|---|
| solubility | Soluble in DMSO (up to 10 mg/ml) |
| form | Red solid. |
| color | Red |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B3931 | Bisindolylmaleimide X hydrochloride ≥90%, solid | 145317-11-9 | 1MG | $140 | 2023-06-20 | Buy |
| Sigma-Aldrich | B3931 | Bisindolylmaleimide X hydrochloride ≥90%, solid | 145317-11-9 | 5MG | $539 | 2023-06-20 | Buy |
| Cayman Chemical | 17511 | Bisindolylmaleimide X (hydrochloride) ≥98% | 145317-11-9 | 1mg | $60 | 2024-03-01 | Buy |
| Cayman Chemical | 17511 | Bisindolylmaleimide X (hydrochloride) ≥98% | 145317-11-9 | 5mg | $201 | 2024-03-01 | Buy |
| TRC | B448525 | BisindolylmaleimideXHydrochloride | 145317-11-9 | 5mg | $165 | 2021-12-16 | Buy |
1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy Chemical Properties,Uses,Production
Description
Ro 31-8425 (145317-11-9) is a selective, reversible, ATP-competitive inhibitor of protein kinase C. Inhibits PKCα, β1, β2, γ and ε, IC50= 8, 8, 14,13 and 39 nM respectively.1? Extremely useful tool for probing PKC-dependent physiology2 or signaling pathways3. Increases MSC adhesion to an ICAM-1 coated substrate in vitro and enables targeted delivery of systematically administered MSCs to inflamed sites in vivo in a CD11a-dependent manner.4? Cell permeable.
Uses
Bisindolylmaleimide X hydrochloride is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCα by Bisindolylmaleimide X and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure.
References
1) Wilkinson et al. (1993), Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C; Biochem. J., 294 335 2) Niu et al. (2011), PKCε regulates contraction-stimulated GLUT4 traffic in skeletal muscle cells; J. Cell Physiol., 226 173 3) Jimenez-Lopez et al. (2005), Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells; J. Pharmacol. Exp. Ther., 312 998 4) Levy et al. (2015), A small-molecule screen for enhanced homing of systemically infused cells; Cell Rep., 10 1261
1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |