LY2334737
- CAS No.
- 892128-60-8
- Chemical Name:
- LY2334737
- Synonyms
- LY2334737;LY 2334737;LY-2334737;LY2334737;2'-Deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)cytidine;Cytidine, 2'-deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)-;anticancer,HEV,Gemcitabine,HEVs,HRVs,LY 2334737,EV-A71,Rhinovirus,inhibit,Nucleoside Antimetabolite/Analog,Enterovirus,HRV,orally,LY2334737,LY-2334737,antiviral,Inhibitor
- CBNumber:
- CB82668271
- Molecular Formula:
- C17H25F2N3O5
- Molecular Weight:
- 389.39
- MDL Number:
- MFCD25976631
- MOL File:
- 892128-60-8.mol
| Density | 1.41±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 9.66±0.20(Predicted) |
| FDA UNII | YLR364XYSA |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
LY2334737 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1815 | LY2334737 99.02% | 892128-60-8 | 5mg | $283 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BL98401 | LY 2334737 | 892128-60-8 | 50mg | $402.5 | 2021-12-16 | Buy |
| ChemScene | CS-1815 | LY2334737 99.02% | 892128-60-8 | 10mg | $432 | 2021-12-16 | Buy |
| AK Scientific | 9607CS | Cytidine,2'-deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)- | 892128-60-8 | 50mg | $593 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BL98401 | LY 2334737 | 892128-60-8 | 10mg | $115 | 2021-12-16 | Buy |
LY2334737 Chemical Properties,Uses,Production
Biological Activity
ly2334737 is an oral prodrug of gemcitabine, the clinically efficacious anticancer agent [1].ly2334737 has been shown the hydrolytic activity by carboxylesterase 2 (ces2). the michaelis-menten kinetic parameters are exhibited to be : km of 43μm and vmax of 40nmol/min/mg protein. in addition, ly2334737 has been found to be cytotoxic to cells in the ncl-60 panel with the ec50 values of 0.512±0.016μm, 0.402±0.018μm and 0.034±0.002μm for pc-gfp alone, hct-116 mock transfectant and hct-116 ces2 transfectant cell lines, respectively. apart from these, the study result has been noted that parental sk-ov-3 cells were approximately 4-fold more sensitive to ly2334737 cytotoxicity than the sk-ov-3 knockdown with the ec50 values of 1.1μm and 4.5μm, respectively [1].
References
[1] pratt se1, durland-busbice s, shepard rl, heinz-taheny k, iversen pw, dantzig ah. human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (ly2334737) and confers prodrug sensitivity to cancer cells. clin cancer res. 2013 mar 1;19(5):1159-68.
LY2334737 Preparation Products And Raw materials
Raw materials
Preparation Products
LY2334737 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 10026 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |