Tocopherol
- CAS No.
- 1406-18-4
- Chemical Name:
- Tocopherol
- Synonyms
- A-TOCOPHEROL;Mixed Tocopherols;DL-TOCOPHEROL;RAC-ALPHA-TOCOPHEROL;ALL-RAC-ALPHA-TOCOPHEROL;DL-ALPHA TOCOPHERYL ACETATE 500;Erevit forte;IRGANOX E 201;DL-PROFECUNDIN;naturalvitaminee
- CBNumber:
- CB8275358
- Molecular Formula:
- C29H50O2
- Molecular Weight:
- 430.71
- MDL Number:
- MFCD00072051
- MOL File:
- 1406-18-4.mol
- MSDS File:
- SDS
| Melting point | 292 °C |
|---|---|
| storage temp. | 0-6°C |
| Odor | Typical vegetable oil |
| LogP | 10.962 (est) |
| FDA 21 CFR | 184.1890 |
| CAS DataBase Reference | 1406-18-4(CAS DataBase Reference) |
| FDA UNII | H4N855PNZ1 |
| NIST Chemistry Reference | «alpha»-Tocopherol(1406-18-4) |
| EPA Substance Registry System | Vitamin E (1406-18-4) |
| Cosmetics Info | Tocopherol |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
Tocopherol Chemical Properties,Uses,Production
Chemical Properties
Viscous oils. Soluble in fats; insoluble in water. Stable to heat in the absence of oxygen, to strong acids, and to visible light; unstable to UV light, alkalies, and oxidation.
Uses
Medicine, nutrition, antioxidants for fats, animal feed additive.
Uses
Fat-soluble vitamin E, which is a light yellow oil readily degradable by heat. As a vitamin, it is essential for normal muscle growth and prevents vitamin A destruction by deterioration. It also functions as an antioxidant. It prevents the oxidation of certain fatty acids and is stable unless the food becomes rancid. Vegetable oils contain a higher concentration of natural antioxidants, including tocopherols, than animal fats and are thus more stable. Tocopherol is obtained from vegetable oils, beans, eggs, and milk. It is also termed alpha-tocopherol.
Definition
(vitamin E). Any of a group of related substances (α-, β-, γ-, andΔ-tocopherol) that constitute vitamin E. The α-form (which occurs naturally as the d-isomer) is the most potent. Occurs naturally in plants, especially wheat germ. All are derivatives of dihydrobenzo-γ-pyran and differ from each other only in the number and position of methyl groups. Vitamin E is required by certain rodents for normal reproduction. Muscular and central nervous system depletion along with generalized edema are deficiency symptoms in all animals. It is not required as a dietary supplement for humans.
Preparation
Tocopherol is synthesised in two ways. One is to extract it from natural plant sources and the other is to obtain it by chemical synthesis. The following are the chemical synthesis routes:
The most important natural raw materials for production of tocopherols by extraction are deodoriser sludges, which are distillates obtained in the deodorisation of vegetable oils. Such distillates contain sterols, sterol esters and triacylglycerols, as well as tocopherols and tocotrienols. The concentration of tocopherols depends on the deodorisation parameters (temperature, vacuum, quantity of injected steam and equipment) but their amount is lower than 10%, usually 8–9 %, of unsaponifiable matter present. Separation of tocopherol from the other distilled compounds is possible by several methods: (1) by esterification with a lower alcohol, washing and vacuum distillation; (2) by saponification, or (3) by fractional liquid–liquid extraction. The concentrates obtained in this way may be purified further by molecular distillation, extraction, crystallisation, or combinations of these procedures.
The tocopherol concentrates recommended as antioxidants are mixtures with relatively high contents of γ-tocopherol and δ-tocopherol (being obtained from soybean oil), but α-tocopherol is also present. The total tocopherol concentration usually lies between 30 and 80%. The rest is constituted of triacylglycerols.
Pharmacology
The antioxidant effects of tocopherol can be translated into different changes at the pharmacodynamic level. In vitro studies have shown that this antioxidant activity can produce modification in protein kinase C (PKC) which will later be translated into an inhibition of cell death. Some other derivate effects are the anti-inflammatory properties of tocopherol which can be related to the modulation of cytokines or prostaglandins, prostanoids and thromboxanes.
Toxicology
Tocopherol is considered as non-toxic but if very high doses are administered, there are reports of hemorrhagic activity. Reproductive and developmental toxicity tests are negative. These negative results were also observed in the analysis of mutagenicity and carcinogenicity.
Tocopherol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-13102810335 | admin@hbsaisier.cn | China | 747 | 58 |
| Hebei Dangtong Import and export Co LTD | +8615632927689 | admin@hbdangtong.com | China | 991 | 58 |
| shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 | sales@sdperfect.com | China | 294 | 58 |
| Hebei Anlijie Biotechnology Co., Ltd | +8619031013551 | ably@aljbio.com | China | 177 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 290 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
Related Qustion
- Q:What are the key factors effecting Tocopherol synthesis?
- A:Tocopherols belong to the vitamin E group of fat-soluble antioxidants, which are essential for human nutrition. Tocopherol cyc....
- Jan 12，2024
View Lastest Price from Tocopherol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-26 | Tocopherol
1406-18-4
|
US $50.00-40.00 / kg | 1kg | 99% | 20Tons | Hebei Dangtong Import and export Co LTD | |
 |
2024-04-25 | Vitamin E
1406-18-4
|
US $6.00 / KG | 1KG | 99% | 20TONS | Hebei Longbang Technology Co., Ltd | |
 |
2024-04-22 | Tocopherol
1406-18-4
|
US $0.00 / kg | 1kg | 99.8% | 1000 kg | BINBO BIOLOGICAL CO.,LTD |
-
- Tocopherol
1406-18-4
- US $50.00-40.00 / kg
- 99%
- Hebei Dangtong Import and export Co LTD
-
- Vitamin E
1406-18-4
- US $6.00 / KG
- 99%
- Hebei Longbang Technology Co., Ltd
-
- Tocopherol
1406-18-4
- US $0.00 / kg
- 99.8%
- BINBO BIOLOGICAL CO.,LTD