3,5-Dimethyl-1H-pyrrole-2-carboxaldehyde
- CAS No.
- 2199-58-8
- Chemical Name:
- 3,5-Dimethyl-1H-pyrrole-2-carboxaldehyde
- Synonyms
- 3,5-DIMETHYL-1H-PYRROLE-2-CARBALDEHYDE;1H-Pyr;PYR-9588;Sunitinib Impurity 51;3, 5-dimethyl-2-pyrrolidene;2-ForMyl-3,5-diMethylpyrrole;3,5-Dimethyl-2-formyl-1H-pyrrole;2,4-DiMethylpyrrole-5-carboxaldehyde;3,5-Dimethyl-2-pyrrolecarboxaldehyde;3,5-DIMETHYLPYRROLE-2-CARBOXALDEHYDE
- CBNumber:
- CB8468167
- Molecular Formula:
- C7H9NO
- Molecular Weight:
- 123.15
- MDL Number:
- MFCD00111522
- MOL File:
- 2199-58-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 95-99 °C (lit.) |
|---|---|
| Boiling point | 237.3±35.0 °C(Predicted) |
| Density | 1.099±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO, Methanol |
| pka | 16.23±0.50(Predicted) |
| form | Solid |
| color | Light Brown |
| Sensitive | Air Sensitive |
| InChI | InChI=1S/C7H9NO/c1-5-3-6(2)8-7(5)4-9/h3-4,8H,1-2H3 |
| InChIKey | RDFZYUOHJBXMJA-UHFFFAOYSA-N |
| SMILES | N1C(C)=CC(C)=C1C=O |
| CAS DataBase Reference | 2199-58-8(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
3,5-Dimethyl-1H-pyrrole-2-carboxaldehyde price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 640514 | 3,5-Dimethylpyrrole-2-carboxaldehyde 95% | 2199-58-8 | 1g | $95.4 | 2026-04-30 | Buy |
| TCI Chemical | D3950 | 3,5-Dimethyl-2-pyrrolecarboxaldehyde >98.0%(GC) | 2199-58-8 | 1g | $114 | 2026-04-30 | Buy |
| TCI Chemical | D3950 | 3,5-Dimethyl-2-pyrrolecarboxaldehyde >98.0%(GC) | 2199-58-8 | 5g | $390 | 2026-04-30 | Buy |
| TRC | TRC-D446690-500MG | 3,5-Dimethyl-1H-pyrrole-2-carboxaldehyde | 2199-58-8 | 500mg | $84 | 2026-06-03 | Buy |
| TRC | TRC-D446690-2G | 3,5-Dimethyl-1H-pyrrole-2-carboxaldehyde | 2199-58-8 | 2g | $223 | 2026-06-03 | Buy |
3,5-Dimethyl-1H-pyrrole-2-carboxaldehyde Chemical Properties, Uses, Production
Chemical Properties
Colorless solid
Uses
3,5-Dimethyl-1H-pyrrole-2-carboxaldehyde is an intermediate used in the synthesis of a series of anaplastic lymphoma kinase (ALK) inhibitors, a new target for therapy of non-small-cell lung cancer (NSCLC).
Synthesis
625-82-1
2199-58-8
General procedure for the synthesis of 3,5-dimethyl-2-pyrrolecarboxaldehyde from 2,4-dimethylpyrrole: A. Under argon protection, dimethylformamide (4.5 mL, 57.8 mmol) was cooled to 0 °C, followed by dropwise addition of phosphorus trichloride (57.8 mmol) over 5 min. The cooling bath was removed and after 15 minutes of reaction, 1,2-dichloroethane (15 mL) was added. The reaction mixture was cooled again to 0 °C and a 1,2-dichloroethane (15 mL) solution of 2,4-dimethylpyrrole (52.6 mmol) was added dropwise over 15 min. The reaction mixture was heated to reflux maintained for 15 min and then cooled to room temperature. A solution of sodium acetate (24 g) in water (75 mL) was slowly added to the reaction mixture and the resulting mixture was heated to reflux again for 20 minutes. After the reaction mixture was cooled to room temperature, it was diluted with dichloromethane and the aqueous phase was washed with dichloromethane (2 x 50 mL). The organic phases were combined, washed with saturated sodium bicarbonate solution, dried over anhydrous sodium sulfate and concentrated in vacuum. The crude product was purified by silica gel column chromatography with hexane solution of 10% ethyl acetate as eluent to give 5.2 g (80% yield) of the target product 3,5-dimethyl-2-pyrrolecarboxaldehyde. [M + H]+ = 124.1, [M - H]- = 122.0.
References
[1] Patent: US6982265, 2006, B1. Location in patent: Page/Page column 28
[2] Gazzetta Chimica Italiana, 1934, vol. 64, p. 778,782
3,5-Dimethyl-1H-pyrrole-2-carboxaldehyde Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TAIZHOU DKD CHEMICAL CO., LTD. | 0576-58336633 18658336633 | yf.chen@tzdkdchem.com | China | 117 | 58 |
| Changzhou ruiqing medical technology co., LTD | 0519-85859396 15380475813;15380475813 | 656870630@qq.com | China | 389 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 18918157536; | sales8178@energy-chemical.com | China | 45000 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Suzhou haiyu Biochem Industrial Co., LTD | 512-68097639 18013585858 | 744942877@qq.com | China | 915 | 62 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9388 | 66 |
View Latest Price from 3,5-Dimethyl-1H-pyrrole-2-carboxaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 3,5-Dimethyl-1H-pyrrole-2-carboxaldehyde
2199-58-8
|
$70.00-700.00 | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2022-11-09 | 3,5-Dimethyl-1H-pyrrole-2-carboxaldehyde
2199-58-8
|
25kg | 99% | 20 tons | TAIZHOU DKD CHEMICAL CO., LTD. | ||
 |
2021-07-10 | 2,6-DIMETHYL-3-HYDROXYPYRIDINE
2199-58-8
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 3,5-Dimethyl-1H-pyrrole-2-carboxaldehyde
2199-58-8
- $70.00-700.00
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- 3,5-Dimethyl-1H-pyrrole-2-carboxaldehyde
2199-58-8
- $0.00
- 99%
- TAIZHOU DKD CHEMICAL CO., LTD.
-
- 2,6-DIMETHYL-3-HYDROXYPYRIDINE
2199-58-8
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
