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Diazapam structure
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

Diazapam Properties

Melting point:
1.2245 (rough estimate)
refractive index 
1.6330 (estimate)
Flash point:
11 °C
storage temp. 
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.6 mg/mL
3.4(at 25℃)
Stable. Light-sensitive. Incompatible with strong oxidizing agents.
CAS DataBase Reference
439-14-5(CAS DataBase Reference)
NIST Chemistry Reference
2H-1,4-benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl-(439-14-5)
EPA Substance Registry System
2H-1,4-Benzodiazepin- 2-one, 7-chloro-1,3-dihydro-1-methyl- 5-phenyl-(439-14-5)


Hazard Codes  Xn,T,F,Xi
Risk Statements  21/22-39/23/24/25-23/24/25-11-36/37/38
Safety Statements  36/37-45-36-26-16-7
RIDADR  UN 2811 6.1/PG 3
WGK Germany  2
RTECS  DF1575000
HazardClass  6.1(b)
PackingGroup  III
Hazardous Substances Data 439-14-5(Hazardous Substances Data)

Diazapam price

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Diazapam Chemical Properties,Uses,Production

Chemical Properties

Light Yellow Crystalline Solid

Chemical Properties

Diazepam is a yellow crystalline powder.


Anxiolitic; muscle relaxant (skeletal); anticonvulsant. Controlled substance (depressant)


Anxiolytic; muscle relaxant (skeletal); anticonvulsant. Controlled substance (depressant).


Diazepam is an anxiolytic; muscle relaxant (skeletal); anticonvulsant. Diazepam is a controlled substance (depressant).

brand name

Diastat (Valeant); Dizac (Pharmacia & Upjohn); Q-Pam (Quantum Pharmics); Valium (Roche).

General Description

Off-white to yellow crystalline powder. Practically odorless. Tasteless at first with a bitter aftertaste.

General Description

Diazepam is given orally (Valium) or rectally (Diastat) as anadjunctive treatment in patients with generalized tonic–clonicstatus epilepticus (i.e., an acute and potentially fatal seizure)or in patients with refractory epilepsy in combination withother AEDs.For details on diazepam (Valium), see its discussionunder anxiolytics and sedative–hypnotic agents.

General Description

Diazepam, 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepine-2-one .Like chlordiazepoxide, repeated administration of diazepamleads to accumulation of an active nordazepam,which can be detected in the blood for more than 1 weekafter discontinuation of the drug. This drug is a long actingfor the same reason. Diazepam is metabolized to nordazepamby CYP2C19 and CYP3A4. Cimetidine, by inhibitingCYP3A4, decreases the metabolism and clearanceof diazepam. Thus, drugs that affect the activityof CYP2C19 or CYP3A4 may alter diazepam kinetics.Because diazepam clearance is decreased in the elderlyand in patients with hepatic insufficiency, a dosage reductionmay be warranted. It is widely used for several anxietystates and has an additional wide range of uses (e.g., asan anticonvulsant, a premedication in anesthesiology, andin various spastic disorders).

Air & Water Reactions

Hydrolysis occurs in aqueous solutions with a maximum stability around pH 5. . Insoluble in water.

Fire Hazard

Flash point data for Diazapam are not available; however, Diazapam is probably combustible.

Biological Activity

Ligand at the GABA A receptor benzodiazepine modulatory site. Anxiolytic, anticonvulsant and sedative/hypnotic agent.

Safety Profile

Poison by ingestion, parenteral, subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by skin contact. Questionable carcinogen with experimental tumorigenic data. Human systemic effects: dermatitis, effect on inflammation or mediation of inflammation, change in cardiac rate, somnolence, respiratory depression, and other respiratory changes, visual field changes, diplopia (double vision), change in motor activity, muscle contraction or spasticity, ataxia (loss of muscle coordination), an antipsychotic and general anesthetic. Human reproductive effects by ingestion and intravenous routes causing developmental abnormalities of the fetal cardiovascular (circulatory) system and postnatal effects. Experimental teratogenic and reproductive effects. Human mutation data reported. An allergen. A drug for the treatment of anxiety. When heated to decomposition it emits very toxic fumes of Cl and NOx.


UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Diazapam Preparation Products And Raw materials

Raw materials

Preparation Products

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Diazapam Spectrum

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