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Halcinonide

Outline Physical and Chemical Properties Pharmacological effects Indications Adverse reactions Contraindications Precautions Specification Uses
Halcinonide
Halcinonide structure
CAS No.
3093-35-4
Chemical Name:
Halcinonide
Synonyms
halog;halcort;Adcortin;SQ 18566;halcimat;halciderm;Alcinonide;HALCINONIDE;Halcinonide CP2000;Halcinonide Impurity
CBNumber:
CB9106428
Molecular Formula:
C24H32ClFO5
Formula Weight:
454.96
MOL File:
3093-35-4.mol

Halcinonide Properties

Melting point:
264-265° (dec)
alpha 
D25 +155° (CHCl3)
Density 
1.1567 (estimate)
CAS DataBase Reference
3093-35-4(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  63
Safety Statements  36
WGK Germany  3
RTECS  TU5010200
HS Code  2937220000
Toxicity LD50 i.p. in mice: 150 mg/kg (Millonig, Yiakas)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Halcinonide price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1302509 Halcinonide United States Pharmacopeia (USP) Reference Standard 3093-35-4 200mg $352.8 2018-11-20 Buy
Cayman Chemical 23780 Halcinonide ≥98% 3093-35-4 10mg $25 2018-11-19 Buy
Cayman Chemical 23780 Halcinonide ≥98% 3093-35-4 25mg $56 2018-11-19 Buy
Cayman Chemical 23780 Halcinonide ≥98% 3093-35-4 50mg $94 2018-11-19 Buy
Cayman Chemical 23780 Halcinonide ≥98% 3093-35-4 100mg $175 2018-11-19 Buy

Halcinonide Chemical Properties,Uses,Production

Outline

Halcinonide is an efficient synthetic fluorine and chlorine corticosteroid, the effect of it is similar to fludrocortisone . It has strong anti-inflammatory, anti-allergic, anti-itching, inhibiting proliferation of immune effects, topical application can reduce the permeability of the capillary wall and cell membrane,and reduce the inflammatory exudate, and inhibit histamine and other inflammatory mediators formation and release.it is clinically used for subacute or chronic non-infectious skin diseases such as psoriasis, eczema, neurodermatitis, contact dermatitis, seborrheic dermatitis (non-face), atopic dermatitis, flat moss and discoid lupus erythematosus and the like which are hormone therapy ineffective .

Physical and Chemical Properties

White or off-white crystalline powder, odorless. Almost insoluble in water, slightly soluble in ethanol or methanol, soluble in acetone and chloroform. Sealed.

Pharmacological effects

This drug is a potent synthetic glucocorticoid ,its action is similar to fludrocortisone. It has strong anti-inflammatory, anti-allergic, anti-itching, inhibit proliferation of immune and other effects, topical application are unlikely to cause systemic adverse reactions. The drug has the same effect of inhibiting the proliferation of granulation tissue as dexamethasone ,it is stronger than hydrocortisone. The drug is not substantially absorbed in external skin, it has no irritating effect on the body. The extent of absorption of topical application is hugely different among anatomic sites: forearm 1%, 4% of the scalp, forehead, 7%, 36% of the scrotum, the greatest penetration is in the groin, armpits and face. The drug is mainly metabolized in the liver, it is mostly excreted by the kidneys, and less by biliary excretion.
The above information is edited by the chemicalbook of Tian Ye.

Indications

The drug is suitable for treatment of contact dermatitis, atopic dermatitis, lichen,the small size of psoriasis, lichen, heat rash, genital atrophic lichen sclerosus, non-parasitic prurigo, ring granuloma, discoid lupus erythematosus, non-facial seborrheic dermatitis, mycosis fungoides pruritus symptomatic .It is also used for the treatment of insect bites, parasitic prurigo through specific treatment. It has a good effect on the treatment of psoriasis .

Adverse reactions

1. There are a small number of patients whose applicator parts of the skin occurs burning, stinging, itching temporary, long-term use can occur telangiectasia skin (especially face), skin atrophy, stretch marks (teenagers prone), fragile skin, hirsutism, folliculitis, milia, skin bleaching, delayed ulcer healing, packet method in skin folds easily causes fungal infection.
2. When it is much absorbed through the skin, it can cause systemic adverse reactions.

Contraindications

1.Patients who are allergic to this drug and adrenal corticosteroids are banned.
2. The primary skin diseases , exudative dermatitis, ulcerative lesions, acne, rosacea caused by bacteria, fungi, viruses and parasites are banned.
3. It is forbidden using in the eyelid portion (cause a risk of glaucoma).

Precautions

1. The large area of large quantities of drugs or medication packet mode allow more amount of the drug being absorbed through the skin, which causes systemic reactions, especially in young children and infants, it can cause reversible Cushing's syndrome and growth retardation, sudden withdrawal can cause acute adrenal insufficiency.
2. When the local intolerance phenomena occurs,the drug should be stopped and the reason should be found.
3. It should be paid attention that drug staying in the skin folds and diaper can be absorbed into the body.

Specification

Ointments, creams, solutions: 0.1%.

Uses

Cortical hormone drugs for the treatment of psoriasis and eczema dermatitis .

Uses

Anti-inflammatory (topical).

brand name

Halog (Bristol-Myers Squibb); Halog (Westwood-Squibb).

General Description

Halcinonide, 21-chloro-9-fluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione, was the first chloroGC marketed. Likemany other potent GCs, it is used only topically.

Halcinonide Preparation Products And Raw materials

Raw materials

Preparation Products


Halcinonide Suppliers

Global( 142)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3202 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21756 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 535 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 27142 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23962 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28237 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58

View Lastest Price from Halcinonide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-17 Halcinonide
3093-35-4
US $7.00 / kg 1kg 99% 100KG career henan chemical co
2018-03-09 Halcinonide
3093-35-4
US $100.00 / KG 10G 99.9% 100kg/week Hubei XinRunde Chemical Co., Ltd.

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