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Flibanserin

description Uses Application Mechanism of action Drugs for enhancing female sexuality
Flibanserin
Flibanserin structure
CAS No.
167933-07-5
Chemical Name:
Flibanserin
Synonyms
Girosa;Bimt 17;Fbanselin;BIMT 17BS;Flubanserin;Flibanserin;Filbanserin;Flibanerins;Flibaneserin;Flibanserine
CBNumber:
CB91178756
Molecular Formula:
C20H21F3N4O
Formula Weight:
390.4
MOL File:
167933-07-5.mol

Flibanserin Properties

Density 
1.292±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble10mg/mL, clear
form 
powder
pka
12.12±0.30(Predicted)
color 
white to beige
InChIKey
PPRRDFIXUUSXRA-UHFFFAOYSA-N
FDA UNII
37JK4STR6Z
NCI Drug Dictionary
flibanserin
ATC code
G02CX02
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319-H335
Precautionary statements  P261-P301+P310-P305+P351+P338
Hazard Codes  T
Risk Statements  25-36/37/38
Safety Statements  26-45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3

Flibanserin price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0797 Flibanserin ≥98% (HPLC) 167933-07-5 5mg $72.1 2021-03-22 Buy
Sigma-Aldrich SML0797 Flibanserin ≥98% (HPLC) 167933-07-5 25mg $291 2021-03-22 Buy
Cayman Chemical 19203 Flibanserin ≥98% 167933-07-5 10mg $86 2021-03-22 Buy
Cayman Chemical 19203 Flibanserin ≥98% 167933-07-5 5mg $45 2021-03-22 Buy
Cayman Chemical 19203 Flibanserin ≥98% 167933-07-5 25mg $169 2021-03-22 Buy

Flibanserin Chemical Properties,Uses,Production

description

Flibanserin (Addyi-Sprout Pharmaceuticals) is a first-in-class oral medication approved by FDA for the treatment of acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. Although it meets the need for drugs that address women's sexual function, flibanserin is unlike agents that treat erectile dysfunction, as it is intended to increase sexual desire, not performance.
Flibanserin is the first prescription medicine for the treatment of this sexual dysfunction. The FDA approval is not without warnings; flibanserin is subject to the Risk Evaluation and Mitigation Strategy (REMS) to ensure safe use by patients, and has a boxed warning directed to prescribing providers. The goal is to inform patients and providers of the increased risk of hypotension and syncope (Vallejos 2017).

Uses

Filbanserin is an agonist of serotonin-5HT1A receptor and an antagonist of the 5-HT2A receptor. Binds dopamine receptors with Ki values ranging from 4-24 nM. Used to treat hypoactive sexual desire disorder in females.

Application

Flibanserin is an N-alkylpiperazine that is 1-[2-(1,3-dihydro-2-oxobenzimidazol-1-yl)ethyl]piperazine in which the remaining amino proton is replaced by a 3-(trifluoromethyl)phenyl group. A multifunctional serotonin agonist and antagonist which is used for the treatment of pre-menopausal women with hypoactive sexual desire disorder. Flibanserin has a role as a serotonergic agonist, a serotonergic antagonist and an antidepressant. Flibanserin is a member of benzimidazoles, a N-arylpiperazine, a N-alkylpiperazine and an organofluorine compound.

Mechanism of action

Flibanserin is a novel multifunctional serotonin agonist and antagonist (MSAA) that improves sexual functioning in premenopausal women who suffer from reduced sexual interest and desire.Flibanserin theoretically improves sexual functioning by enhancing downstream release of dopamine and norepinephrine while reducing serotonin release in the brain circuits that mediate symptoms of reduced sexual interest and desire.
Flibanserin has demonstrated clinical efficacy in premenopausal women who have reduced interest in and desire for sex and has 2 principal pharmacologic actions in microcircuits: it is a full agonist at postsynaptic serotonin 5HT1A receptors and an antagonist at postsynaptic 5HT2A receptors..Flibansetrin has high affinity for serotonin receptors in the brain: it acts as an agonist on 5-HT1A and an antagonist on 5-HT2A. In vivo, flibanserin binds equally to 5-HT1A and 5-HT2A receptors.

Drugs for enhancing female sexuality

Flibanserin is the world's first New drug for enhancing female sexuality. It can reduce the amount of 5-hydroxytryptamine which inhibits sexuality and improve sexual stimulant dopamine levels. It is already submitted to Food and Drug Administration of the United States for approval.
This drug can directly effect on the  sexual pleasure control area of the female brain to restore female Flagging libido. By adjusting the aphrodisiac body system, Flibanserin Helps to restore the balance of sexual appetite suppression and exciting mechanism and lead to form a healthy sexual performance. The curative effect can be obtained a few weeks later. At the same time, the female viagra also has a certain side effects. One-eighth of tested women appeared dizziness, fatigue and sleepiness.
Similar to antidepressants, Flibanserin will affect the brain secretion chemicals associated with emotions and desires. In fact, it was used as a drug for the treatment of depression before before it becomes a sex medicine.
Different from the working principle of "viagra", Flibanserin works by adjusting the chemicals in female brains.
In addition, "viagra" only works for most men, Flibanserin has effects on women with low libido. If the patient does not have a sexual interest to someone, Flibanserin will not affect her. Flibanserin will not cause hyperaphrodisia. Clayton. Anita, adviser of the drug companies says :“it is not an aphrodisiac and it only helps to balance the chemicals in the female brain to make a female restore sex desire, but not more than the normal level. However, it takes some time for this drug to work and women should take the drug every day.
Flibanserin tablet
Figure 1 shows Flibanserin tablet.

Description

Flibanserin is a drug originally developed by Boehringer-Ingelheim and later Sprout Pharmaceuticals, which was approved in 2015 by the FDA for the treatment of premenopausal women with hypoactive sexual desire disorder (HSDD). The drug, which was originally developed for the treatment of depression by Boehringer- Ingelheim, is a full agonist of the 5-HT1A receptor, an antagonist of the 5-HT2A receptor, and a partial agonist of the dopamine-4 (D4) receptor, which triggers increased dopamine and norepinephrine levels along with decreased serotonin levels. In three randomized trials involving 2400 premenopausal women, the drug was found to increase the number of satisfying sexual events by 0.5-1.0 events per month and increased sexual desire on average by 10-12% over placebo. Side effects include decreased blood pressure and loss of consciousness, especially in subjects who consumed alcohol.

Uses

Antidepressant (5-HT1a agonist and 5-HT2 antagonist).

Chemical Synthesis

The large-scale synthesis of flibanserin (X) mostly follows a patent from Symed Laboratories Limited which demonstrated hundred-gram-scale preparation of the drug as described in Scheme. Starting from commercially available 1-(prop-1- en-2-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one (74), installation of an ethylene side chain was accomplished under conventional alkylation conditions with 1,2-dibromoethane and base, and this event was immediately followed by a second alkylation reaction involving piperazine to secure piperazinyl benzimidazolone 75. Interestingly, the enamine double bond within 74 was apparently reduced to the corresponding isopropyl group under these conditions. Although the authors do not comment about this reduction directly, similar examples of olefin reduction under non-hydrogenative alkylation conditions have been reported in the literature separately by both Pai and Ryu. Removal of the isopropyl group was facilitated by means of aqueous sodium hydroxide to afford 76, which underwent N-arylation under Buchwald conditions with 1-bromo-3-(trifluoromethyl)benzene 77 to furnish flibanserin (X) in 63% yield.

Flibanserin Preparation Products And Raw materials

Raw materials

Preparation Products


Flibanserin Suppliers

Global( 273)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hong Kong Tiansheng New Material Trading Co., Ltd
+8617320695765
17320695765 zxx@hktiansheng.com China 492 58
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58
Hebei Miaobian Biotechnology Co., Ltd
17733850068 +8617733850068
Iglesia@cnhbmiaobian.com CHINA 880 58
Baoji Guokang Bio-Technology Co., Ltd.
09173909592
09173909592 cngksw@aliyun.com CHINA 9441 58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
18802962783
rebecca@tgybio.com CHINA 1217 58
Guangzhou TongYi biochemistry technology Co.,LTD
+8613073028829
mack@tongyon.com China 3001 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55

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View Lastest Price from Flibanserin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-04 Flibanserin
167933-07-5
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-12-03 Flibanserin
167933-07-5
US $400.00-35.00 / KG/CTN 1KG 99% 1000kg/month Shanxi Lianxu New Material Co., LTD
2021-12-03 Flibanserin
167933-07-5
US $10.00 / Kg/Bag 1KG 99% 10 Tons Hebei Senko Biotechnology Co., Ltd.

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