Chinese Japanese Germany Korea


Avanafil structure
Chemical Name:
D03217;avanfil;vanafil;Stendra;AVANAFE;Avanafil;Avanafil-d3;O cut the non;Avanafil(TA-1790);Avanafil fandachem
Molecular Formula:
Formula Weight:
MOL File:

Avanafil Properties

Melting point:
storage temp. 
Sealed in dry,Store in freezer, under -20°C
CAS DataBase Reference
330784-47-9(CAS DataBase Reference)
NCI Drug Dictionary
  • Risk and Safety Statements
HS Code  29339900

Avanafil price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 23024 Avanafil ≥98% 330784-47-9 100mg $25 2021-03-22 Buy
Cayman Chemical 23024 Avanafil ≥98% 330784-47-9 250mg $56 2021-03-22 Buy
Cayman Chemical 23024 Avanafil ≥98% 330784-47-9 500mg $94 2021-03-22 Buy
Cayman Chemical 23024 Avanafil ≥98% 330784-47-9 1g $163 2021-03-22 Buy

Avanafil Chemical Properties,Uses,Production


Avanafil (Zepeed) was approved by the Korean Health Ministry for the treatment of erectile dysfunction (ED) in August 2011. Avanafil is a highly selective type 5 phosphodiesterase (PDE5) inhibitor. Avanafil is reported to be the most selective PDE5 inhibitor on the market. The onset of Tmax and half-life also varies among the marketed PDE5 inhibitors. Sildenafil has a Tmax at 1 h and a half-life of 3–5 h. Vardenafil is somewhat similar with a Tmax of 0.6 h and a half-life of 4–6 h. Tadalafil has the longest half-life among the marketed drugs with a half-life of 17 h. Avanafil has a fast onset of action reaching Tmax in 0.6 h with a half-life of 1.2 h. A synthesis of avanafil (TA-1790) is described in the patent literature. The main elimination route of avanafil is through the bile and feces. Avanafil was also found to be reabsorbed through enterohepatic recirculation.

Chemical Properties

White Solid


Mitsubishi Tanabe Pharma Corporation (Japan)


A phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction.


Avanafil is a highly selective PDE5 inhibitor with IC50 of 1 nM.


ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4-[(3-chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid with the amino group of pyrimidin-2-ylmethylamine Used for treatment of erectile dysfunction.

brand name


Clinical Use

Avanafil was originally discovered at Tanabe Seiyaku (now Mitsubishi Tanabe). JW Pharmaceutical (previously Choongwae Pharma) and VIVUS have since developed and launched avanafil, which is an oral PDE5 inhibitor for the treatment of erectile dysfunction (ED). Although many marketed PDE5 inhibitors (e.g. sildenafil, vardenafil and tadalafil) are available for the treatment of ED, many patients are still unable to achieve the desired results and experience undesired side-effects with these existing medications. As such, second-generation PDE5 inhibitors with enhanced PDE5 selectivity, shorter systemic half-lives, and improved tolerability are desired. Developed to meet these criteria, Avanafil exhibited good oral bioavailability and PDE5 selectivity in both preclinical studies and clinical trials. Avanafil had a short onset of action (35 min) and short half-life (1.5 h).

Chemical Synthesis

The synthesis presented is based on the published patent procedure and is outlined in the scheme. Commercially available 4-chloro-2-(methylsulfanyl)pyrimidine- 5-carboxylic acid ethyl ester (25) was treated with 3- chloro-4-methoxybenzylamine (26) and triethylamine at room temperature to give 4-benzylaminopyrimidine derivative 27 in 96% yield. Sulfide 27 was then oxidized with m-chloroperbenzoic acid (m-CPBA), followed bytreatment with L-prolinol and triethylamine to afford ethyl pyrimidinate 28 in 83% yield. This ester was then saponified with 10% sodium hydroxide to give pyrimidine- 5-carboxylic acid 29 in 80% yield, which then underwent conventional amide bond formation using 2-(aminomethyl) pyrimidine (29a), N-(3-dimethylaminopropal)-N0-ethylcarbodiimide hydrochloride (EDCI) and 1-hydroxybenzotriazole hydrate (HOBt) to give avanafil (IV) in 83% yield.

Avanafil Preparation Products And Raw materials

Raw materials

Preparation Products

Avanafil Suppliers

Global( 303)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu CHINA 13187 58
Hubei XinRunde Chemical Co., Ltd.
02783214688 CHINA 567 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-34979012 CHINA 739 60
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 CHINA 1817 55
hdzhl biotechnology co., ltd
86-13032617415 CHINA 1275 58
Pharmahands (Taizhou) Co., Ltd.
+86 523-86200360
CHINA 358 58
Shanghai Payne Pharmaceutical Technology Co.Ltd
18678586262 021-58123769 China 1355 58
Wuhan Monad Medicine Tech Co.,LTD
18771942761 02768782018 CHINA 1000 58
Shanghai UCHEM Inc.
15502138767 15502138767 CHINA 2667 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55

Related articles

View Lastest Price from Avanafil manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-21 Avanafil
US $1.00 / g 1000g 99% 20ton/month Wuhan Aoliqisi New Material Technology Co., Ltd.
2021-10-21 Avanafil
US $30.00 / g 1000g 99% 20ton/month Wuhan Aoliqisi New Material Technology Co., Ltd.
2021-10-20 Avanafil
US $500.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd

330784-47-9(Avanafil)Related Search:

Copyright 2017 © ChemicalBook. All rights reserved