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Flumazenil

Flumazenil
Flumazenil structure
CAS No.
78755-81-4
Chemical Name:
Flumazenil
Synonyms
FMZ;YM-684;ANEXATE;Mazicon;Lanexat;Ro 1722;Romazicon;Flumazepil;FluMenazil;Ro 41-8157
CBNumber:
CB9208108
Molecular Formula:
C15H14FN3O3
Formula Weight:
303.29
MOL File:
78755-81-4.mol

Flumazenil Properties

Melting point:
201-203°C
storage temp. 
2-8°C
solubility 
Soluble in DMSO to 25mM
form 
solid
color 
white
Water Solubility 
128 mg/L
Merck 
14,4135
CAS DataBase Reference
78755-81-4(CAS DataBase Reference)
NIST Chemistry Reference
Flumazenil(78755-81-4)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-27-36/37/39
WGK Germany  2
RTECS  NI2922170
HS Code  2933997500
Toxicity LD50 in mice, rats (mg/kg): 4000, 1360 i.p.; 4300, 6000 orally (Hunkeler)

Flumazenil price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F6300 Flumazenil >99% (HPLC), solid 78755-81-4 25mg $313 2018-11-20 Buy
Sigma-Aldrich 1273808 Flumazenil United States Pharmacopeia (USP) Reference Standard 78755-81-4 200mg $1740 2018-11-13 Buy
TCI Chemical F0958 Flumazenil >99.0%(GC) 78755-81-4 25mg $58 2018-11-22 Buy
TCI Chemical F0958 Flumazenil >99.0%(GC) 78755-81-4 100mg $170 2018-11-22 Buy
Alfa Aesar J62537 Flumazenil, 98% 78755-81-4 500mg $1078 2018-11-13 Buy

Flumazenil Chemical Properties,Uses,Production

Description

Flumazenil is a benzodiazepine antagonist useful as a fast-acting antidote in the treatment of benzodiazepine intoxication, and in reversing the central sedative effects of benzodiazepines during anesthesia.

Chemical Properties

Colourless crystals

Originator

Hoffmann-La Roche (Switzerland)

Uses

A benzodiazepine antagonist

Uses

Imidazodiazepine which selectively blocks the central effects of classic benzodiazepines. It is used as benzodiazepine antagonist.

Uses

beta-blocker, antihypertensive

Uses

benzodiazepine antagonist sedation reversal drug

Definition

ChEBI: An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an ntidote to benzodiazepine overdose.

brand name

Romazicon (Roche);Anexate.

Biological Activity

Benzodiazepine antagonist, non-selective for α 1, α 2, α 3 or α 5-containing GABA A receptors. Centrally active upon systemic administration in vivo .

Veterinary Drugs and Treatments

Flumazenil may be useful for the reversal of benzodiazepine effects after either therapeutic use or overdoses. Flumazenil may be of benefit in the treatment of encephalopathy in patients with severe hepatic failure.

Flumazenil Preparation Products And Raw materials

Raw materials

Preparation Products


Flumazenil Suppliers

Global( 210)Suppliers
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Henan DaKen Chemical CO.,LTD.
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Hubei Jusheng Technology Co.,Ltd.
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QUALITY CONTROL CHEMICALS INC.
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