Triphosphopyridine nucleotide

Triphosphopyridine nucleotide Properties

storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	H₂O: 50 mg/mL, clear, slightly yellow
form	powder to crystal
pka	pKa1 3.9; pKa2 6.1(at 25℃)
color	White to Orange to Green
λmax	260nm(lit.)
Merck	14,6348
InChIKey	XJLXINKUBYWONI-WFYQBQJJNA-N
FDA UNII	BY8P107XEP
EPA Substance Registry System	Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'.fwdarw.5'-ester with 3-(aminocarbonyl)-1-.beta.-D-ribofuranosylpyridinium, inner salt (53-59-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	UU3440000
F	10-21
HS Code	2934.99.9001

Triphosphopyridine nucleotide price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	N5755	β-Nicotinamide adenine dinucleotide phosphate hydrate	53-59-8	100mg	$176	2024-03-01	Buy
Sigma-Aldrich	N5755	β-Nicotinamide adenine dinucleotide phosphate hydrate	53-59-8	1g	$926	2024-03-01	Buy
TCI Chemical	N0943	β-Nicotinamide Adenine Dinucleotide Phosphate [for Biochemical Research] >83.0%(HPLC)	53-59-8	100mg	$120	2024-03-01	Buy
Cayman Chemical	21045	NADP+ ≥90%	53-59-8	50mg	$45	2021-12-16	Buy
Cayman Chemical	21045	NADP+ ≥90%	53-59-8	100mg	$81	2021-12-16	Buy

Product number	Packaging	Price	Buy
N5755	100mg	$176	Buy
N5755	1g	$926	Buy
N0943	100mg	$120	Buy
21045	50mg	$45	Buy
21045	100mg	$81	Buy

Triphosphopyridine nucleotide Chemical Properties,Uses,Production

Description

Triphosphopyridine nucleotide is a coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. Triphosphopyridine nucleotide serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH).

Chemical Properties

Triphosphopyridine nucleotide is white or off-white powder, it is easy to absorb moisture and deliquescence. pKa{1}=3.9; pKa{2}=6.1. It is soluble in water, methanol, insoluble in ethanol, insoluble in ether and ethyl acetate.

Uses

β-Nicotinamide adenine dinucleotide phosphate hydrate is suitable for use in:
the measurement of Glucose-6-phosphate dehydrogenase activity
the Cytochrome P450 3A4 assay as a part of NADPH-regenerating system
the Cytochrome P450 2D6 assay as a part of NADPH-regenerating system
the determination of Glucose-6-phosphate content

Definition

The oxidized form of nicotinamide adenine dinucleotide phosphate (NADP) that receives electrons from photosystem I during photosynthesis. It exists as an anion under normal physiologic conditions.

Biological Functions

Triphosphopyridine nucleotide (NADP) serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH).

Biochem/physiol Actions

β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP).

Synthesis

Triphosphopyridine nucleotide is prepared by the reaction of NADPH. It is synthesised mainly by the interaction of both NfrA1 enzyme and a Bacillus subtilis under the conditions of bacterial luciferase. Reaction conditions were as follows: with hydrogenchloride; NfrA1 enzyme; nitrofurazone; 2-amino-2-hydroxymethyl-1,3-propanediol In water at 23℃; pH=7.0; Enzyme kinetics; Further Variations; Reagents; Oxidation.
Triphosphopyridine nucleotide synthesis

Purification Methods

Purify NMN by passage through a column of Dowex-1 (Clform) and washing with H2O until no absorbance is observed at 260 nm. The tubes containing NMN are pooled, adjusted to pH 5.5-6 and evaporated in vacuo to a small volume. This is adjusted to pH 3 with dilute HNO3 in an ice-bath and treated with 20volumes of Me2CO at 0-5o. The heavy white precipitate is collected by centrifugation at 0o. It is best stored wet and frozen or it can be dried to give a gummy residue. It has max 266nm ( 4,600) and min 249nm ( 3600) at pH 7.0 (i.e. no absorption at 340nm). It can be estimated by reaction with CNor hydrosulfite which form the 4-adducts (equivalent to NADH) which have UV max 340nm ( 6,200). Thus after reaction, an OD340 of one is obtained from a 0.1612mM solution in a 1cm path cuvette. [Plaut & Plaut Biochemical Preparations 5 56 1957, Maplan & Stolzenbach Methods Enzymol 3 899 1957, Kaplan et al. J Am Chem Soc 77 815 1955, Beilstein 22/2 V 168.]

Triphosphopyridine nucleotide Preparation Products And Raw materials

Raw materials

AMBERLITE(R) IRC-50 Trichloroacetic acid [(2R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxy-oxolan-2-yl]me thoxyphosphonic acid

Preparation Products

11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE 5-amino-2,5-dioxo-pentanoic acid 25 MG -NICOTINAMIDE ADENINE DINUCLEOTIDEPHOSPHATE REDUCED.NA4-SALT AN.GR.

Triphosphopyridine nucleotide Suppliers

Global( 333)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Maintain Biotech Co., Ltd.	+86-75589664337 +86-15112661142	cami@maintain-bio.com	China	66	58
Hubei Aumei New Material Co., Ltd.	+86-027-87366298 +8615927270571	tianyi@skbiology.cn	China	294	58
Wuhan Aoliqisi New Material Technology Co., Ltd.	+86-13545906766; +8613545906766	sales@whaop.com	China	265	58
Wuhan Golt Biotech Co., Ltd.	+8615389281203	maria@goltbiotech.com	China	980	58
SyncoZymes (Shanghai) Co., Ltd.,	+86-021-68187180-811 +86-13681683526	lchen@syncozymes.com	China	188	58
Shaanxi LonierHerb Bio Technology Co Ltd	+86-86-+86-86-029-87551862 +8617702909819	sales006@ingredients-lonier.com	China	2596	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Wuhan Haorong Biotechnology Co.,ltd	+8618565342920	sales@chembj.net	China	269	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	1000	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	616	58

Supplier	Advantage
Maintain Biotech Co., Ltd.	58
Hubei Aumei New Material Co., Ltd.	58
Wuhan Aoliqisi New Material Technology Co., Ltd.	58
Wuhan Golt Biotech Co., Ltd.	58
SyncoZymes (Shanghai) Co., Ltd.,	58
Shaanxi LonierHerb Bio Technology Co Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Wuhan Haorong Biotechnology Co.,ltd	58
Shaanxi Haibo Biotechnology Co., Ltd	58
Nantong Guangyuan Chemicl Co,Ltd	58

View Lastest Price from Triphosphopyridine nucleotide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-24	Triphosphopyridine nucleotide 53-59-8	US $0.00-0.00 / KG	1KG	99%	5000	Wuhan Haorong Biotechnology Co.,Ltd
2024-04-12	NADP(Triphosphopyridine nucleotide) 53-59-8	US $0.00 / kg	1kg	99%	2000ton	Shaanxi Haibo Biotechnology Co., Ltd
2024-03-08	NADP zwitterion 53-59-8	US $10.00 / kg	1kg	99%	1000kg	Nantong Guangyuan Chemicl Co,Ltd

Triphosphopyridine nucleotide
53-59-8
US $0.00-0.00 / KG
99%
Wuhan Haorong Biotechnology Co.,Ltd

NADP(Triphosphopyridine nucleotide)
53-59-8
US $0.00 / kg
99%
Shaanxi Haibo Biotechnology Co., Ltd

NADP zwitterion
53-59-8
US $10.00 / kg
99%
Nantong Guangyuan Chemicl Co,Ltd

Triphosphopyridine nucleotide Spectrum

Triphosphopyridine nucleotide(53-59-8)IR1

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B-NICOTINAMIDEADENINEDINUCLEOTIDEPHOSPHATE,HYDRATE TRIPHOSPHOPYRIDINE NUCLEOTIDE CODEHYDROGENASE II BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHORIC ACID BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE REDUCED BETA-NADP β-Nicotinamide adenine dinucleotide phosphate (NADP) BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (NADP+) NADP (b-NicotinaMide adenine dinucleotide phosphate)trihydrate beta-NicotinaMide Adenine Dinucleotide Phosphate [for BiocheMical Research] β-NADP, Coenzyme II, NADP, TPN, Triphosphopyridine nucleotide NADP-ox NADP-oxidized β-Nicotinamide adenine dinucleotide phosphate hydrate,β-NADP, CoenzymeII, NADP, TPN, Triphosphopyridine nucleotide 2’-(dihydrogenphosphate),5’.fwdarw.’-adenosine5’-(trihydrogendiphosphate beta-tpn Triphosphopyridine n Co II Triphosphopyridinnucleotid ATRAZINE NEAT BOTTLE 2,5L SMALL BROWN GLASS DIN45 CHLOROETHANE 200UG/ML IN METHANOL Triphosphopyridine nucleotid Beta-nicotinamide adenine dinucleotide phosphate(NADP+) free base β-nicotinamide adenine dinucleotide phosphate(NADP+) free base codehydraseii cozymaseii enosine2’-(dihydrogenphosphate)5’-(trihydrogenpyrophosphate),innersalt esterwith3-(aminocarbonyl)-1-beta-d-ribofuranosylpyridiniumhydroxide,inner nadphosphate pyridinium,3-carbamoyl-1-beta-d-ribofuranosyl-,hydroxide,5’,5’-esterwithad tpn(nucleotide) NADP(β-Nicotinamide adenine dinucleotide phosphate hydrate) 5'-ester with3-(aminocarbonyl)-1-b-D-ribofuranosylpyridinium, inner salt Adenosine5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'® β-Nicotinamide Adenine Dinucleotide Phosphate [for Biochemical Research] Β-NICOTINAMID-ADENIN-DINUCLEOTID-PHOSPHORSURE NADP zwitterion Adenosine5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'5'-ester with3-(aminocarbonyl)-1-b-D-ribofuranosylpyridinium, inner salt Triphosphopyridine nucleotide(NADP) β-nicotinamide adenine dinucleotide phosphoric acid(NADP+) β-NicotinamideAdenineDinucleotidePhosphate[forBiochemicalResearch]> NADP /Beta-Nicotinamide Adenine Dinucleotide Phosphate Triphosphopyridine nucleotide USP/EP/BP b-Nicotinamide Adenine Dinucelotide Phosphate (Nicotinamide adenine dinucleotide phosphate) Triphosphopyridine nucleotide β-Nicotinamide Adenine Dinucleotide Phosphate [for Biochemical Research] 1-((2R,3R,4S,5R)-5-((((((((2R,3R,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)tetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-3-carbamoylpyridin-1-ium nadide phosphate B-NICOTINAMIDE ADENINE DINUCLEOTIDE*PHOS PHATE FREE β-nicotinamide adenine dinucleotide phosphate hydrate [(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-[[[[(2R,3S,4R,5R)-5-(5-carbamoylpyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxymethyl]-4-hydroxy-oxolan-3-yl]oxyphosphonic acid TPN TPNH Β-NADP BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE NADPH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE