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(S)-(+)-2-Amino-3-methyl-1-butanol

CAS No.
2026-48-4
Chemical Name:
(S)-(+)-2-Amino-3-methyl-1-butanol
Synonyms
L-VALINOL;L-VALINAL;S-VALINOL;H-VAL-OL;L-2-AMINO-3-METHYL-1-BUTANOL;l-2-amino-3-methylbutan-1-ol;(S)-2-AMINO-3-METHYL-1-BUTANOL;M0;val-ol;L-Valino
CBNumber:
CB9319657
Molecular Formula:
C5H13NO
Molecular Weight:
103.16
MDL Number:
MFCD00064296
MOL File:
2026-48-4.mol
MSDS File:
SDS
Last updated:2024-03-22 17:12:53

(S)-(+)-2-Amino-3-methyl-1-butanol Properties

Melting point 30-34 °C
alpha 16 º (c=10,EtOH)
Boiling point 81 °C8 mm Hg(lit.)
Density 0.926 g/mL at 25 °C(lit.)
refractive index n20/D 1.4548(lit.)
Flash point 196 °F
storage temp. Store at +2°C to +8°C.
solubility DMSO (Slightly), Methanol (Slightly)
pka 12.82±0.10(Predicted)
form Liquid After Melting
color Clear slightly yellow
optical activity [α]25/D +10°, c = 10 in H2O
Water Solubility Soluble in water.
Sensitive Air Sensitive
BRN 1719137
InChIKey NWYYWIJOWOLJNR-RXMQYKEDSA-N
CAS DataBase Reference 2026-48-4(CAS DataBase Reference)
FDA UNII R54N4NJ3ZZ
NIST Chemistry Reference (S)-(+)-2-Amino-3-methyl-1-butanol(2026-48-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280a-P305+P351+P338-P321-P332+P313-P337+P313
Hazard Codes  Xi
Risk Statements  36-36/37/38
Safety Statements  26-24/25-36
WGK Germany  3
10-23
HazardClass  IRRITANT
HS Code  29221980
NFPA 704
2
2 1

(S)-(+)-2-Amino-3-methyl-1-butanol price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 186708 (S)-(+)-2-Amino-3-methyl-1-butanol 96% 2026-48-4 1g $54.3 2024-03-01 Buy
Sigma-Aldrich 186708 (S)-(+)-2-Amino-3-methyl-1-butanol 96% 2026-48-4 5g $88 2024-03-01 Buy
Sigma-Aldrich 8.14082 (S)-(+)-2-Amino-3-methyl-1-butanol for synthesis 2026-48-4 1mL $12.3 2024-03-01 Buy
TCI Chemical V0058 L-Valinol >97.0%(GC)(T) 2026-48-4 5g $99 2024-03-01 Buy
TCI Chemical V0058 L-Valinol >97.0%(GC)(T) 2026-48-4 25g $297 2024-03-01 Buy
Product number Packaging Price Buy
186708 1g $54.3 Buy
186708 5g $88 Buy
8.14082 1mL $12.3 Buy
V0058 5g $99 Buy
V0058 25g $297 Buy

(S)-(+)-2-Amino-3-methyl-1-butanol Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

(S)-(+)-2-Amino-3-methyl-1-butanol can be used to prepare:

  • Imines and oxazolines by reacting with aldehydes and nitriles, respectively.
  • Chiral oxazoline derived multidentate ligands containing cyclophosphazene moiety.

Uses

L-Valinol is used as a reagent in the synthesis of simple 1,3-thiazolidine-2-thione derivatives which can exhibit fungicidal activity. L-Valinol is also used as a reagent in the synthesis of small-molecule inhibitors of MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for the treatment of cancer.

Purification Methods

Purify S-valinol by vacuum distillation using a short Vigreux column (p 11). Alternatively it is purified by steam distillation. The steam distillate is acidified with HCl; the aqueous layer is collected and evaporated. The residue is dissolved in butan-1-ol, filtered and dry Et2O added to crystallise the hydrochloride salt (hygroscopic), m 113o. The free base can be obtained by suspending the salt in Et2O and adding small volumes of saturated aqueous K2CO3 until effervescence is complete and the mixture is distinctly alkaline. At this stage the aqueous layer should appear as a white sludge. The mixture is heated to boiling and refluxed for 30minutes (more Et2O is added if necessary). Purification of Biochemicals — Amino Acids and Peptides The Et2O layer is decanted off from the white sludge, the sludge is extracted twice with Et2O (by boiling for a few minutes), the combined organic layers are dried (KOH pellets), evaporated and the residue is distilled in a vacuum. [Nagao et al. J Org Chem 55 1148 1990, Beilstein 4 III 805.]

Global( 502)Suppliers
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Sichuan HongRi Pharma-Tech Co.,Ltd
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Henan Fengda Chemical Co., Ltd
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View Lastest Price from (S)-(+)-2-Amino-3-methyl-1-butanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-Val-OL pictures 2024-05-24 L-Val-OL
2026-48-4
US $0.00-0.00 / kg 1kg 98% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
(S)-(+)-2-Amino-3-methyl-1-butanol pictures 2024-03-23 (S)-(+)-2-Amino-3-methyl-1-butanol
2026-48-4
US $5.00-0.10 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
(S)-(+)-2-Amino-3-methyl-1-butanol pictures 2024-03-16 (S)-(+)-2-Amino-3-methyl-1-butanol
2026-48-4
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
  • L-Val-OL pictures
  • L-Val-OL
    2026-48-4
  • US $0.00-0.00 / kg
  • 98%
  • Sichuan HongRi Pharma-Tech Co.,Ltd
(+)-L-VALINOL L-(+)-VALINOL H-VALINOL H-L-VAL-OL (2S)-2-AMINO-3-METHYL-BUTAN-1-OL L-Valinol ,98% (S)-2-Isopropyl-2-aminoethanol (S)-(+)-2-Amino-3-methyl-1-butanol,96% L-Valinol ,98% [ee: 95%] L-Valinol ,95% (S)-(+)-2-Amino-3-me L-Valino (S)-(+)-2-AMino-3-Methyl-1-butanol, 96% 1ML (S)-(+)-2-AMINO-3-METHYL-1-BUTANOL FOR S (S)-(+)-2-Amino-3-methyl-1-butanol(L-Valinal) L-Valinol, 98%, ee: 95% PKC PharMaceuticals, Inc. L - valerian aMMonia alcohol L-(+)-Valinol (S)-(+)-2-Amino-3-methyl-1-butanol L-2-Amino-3-methylbutan-1-ol (S)-(+)-2-Amino-3-methyl-1-butanol 96% L-Valinol Free Base L-Valinol, ee: 95% L-Valinol≥ 98% (GC) L-Valinol,99%e.e. L-Valinol,Elvitegravir intermediate 1-Butanol, 2-amino-3-methyl-, (S)- (S)-(+)-2-Amino-3-methyl-1-butanol~H-Val-ol Valinol,97% (R)-(+)-2-Amino-3-methyl-1-butanolL-Valanol L-Valinol(S)-(+)-2-Amino-3-methyl-1-butanol L-Valanol (S)-(+)-2-AMINO-3-METHYL-1-BUTANOL, 96% (95% EE/GLC) L-Val-ol (S)-2-AMINO-3-METHYL-1-BUTANOL 98.0% 1-Butanol, 2-amino-3-methyl-, (2S)- (S)-2-AMINO-3-METHYL-L-BUTANOL (S)-(+)-2-AMINO-3-METHYL-BUTANOL (S)-2-AMINO-3-METHYL-BUTAN-1-OL (S)-(+)-2-AMINO-3-METHYL-1-BUTANOL S-(-)-2-AMINO-3-METHYL-1-BUTANOL H-Val-ol (S)-(+)-2-Amino-3-methyl-1-butanol) -(+)-VaL (S)-(+)-2-Amino-3-methyl-1-butanol USP/EP/BP L-VALINAL L-VALINOL L-2-AMINO-3-METHYL-1-BUTANOL l-2-amino-3-methylbutan-1-ol H-VAL-OL S-VALINOL (S)-2-AMINO-3-METHYL-1-BUTANOL M0 AMG-232-008 (+)-Valinol val-ol 2026-48-4 2046-48-4 226-48-4 AMINE