L-2-Amino-3-methylbutan-1-ol
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- CAS-Nr.
- 2026-48-4
- Bezeichnung:
- L-2-Amino-3-methylbutan-1-ol
- Englisch Name:
- (S)-(+)-2-Amino-3-methyl-1-butanol
- Synonyma:
- L-VALINOL;L-VALINAL;S-VALINOL;H-VAL-OL;L-2-AMINO-3-METHYL-1-BUTANOL;l-2-amino-3-methylbutan-1-ol;(S)-2-AMINO-3-METHYL-1-BUTANOL;M0;val-ol;L-Valino
- CBNumber:
- CB9319657
- Summenformel:
- C5H13NO
- Molgewicht:
- 103.16
- MOL-Datei:
- 2026-48-4.mol
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L-2-Amino-3-methylbutan-1-ol Eigenschaften
- Schmelzpunkt:
- 30-34 °C
- Siedepunkt:
- 81 °C8 mm Hg(lit.)
- alpha
- 16 º (c=10,EtOH)
- Dichte
- 0.926 g/mL at 25 °C(lit.)
- Brechungsindex
- n20/D 1.4548(lit.)
- Flammpunkt:
- 196 °F
- storage temp.
- Store at +2°C to +8°C.
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- pka
- 12.82±0.10(Predicted)
- Aggregatzustand
- Liquid After Melting
- Farbe
- Clear slightly yellow
- Optische Aktivität
- [α]25/D +10°, c = 10 in H2O
- Wasserlöslichkeit
- Soluble in water.
- Sensitive
- Air Sensitive
- BRN
- 1719137
- InChIKey
- NWYYWIJOWOLJNR-RXMQYKEDSA-N
- CAS Datenbank
- 2026-48-4(CAS DataBase Reference)
- NIST chemische Informationen
- (S)-(+)-2-Amino-3-methyl-1-butanol(2026-48-4)
L-2-Amino-3-methylbutan-1-ol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36:Reizt die Augen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
white to light yellow crystal powde
Verwenden
L-Valinol is used as a reagent in the synthesis of simple 1,3-thiazolidine-2-thione derivatives which can exhibit fungicidal activity. L-Valinol is also used as a reagent in the synthesis of small-molecule inhibitors of MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for the treatment of cancer.
läuterung methode
Purify S-valinol by vacuum distillation using a short Vigreux column (p 11). Alternatively it is purified by steam distillation. The steam distillate is acidified with HCl; the aqueous layer is collected and evaporated. The residue is dissolved in butan-1-ol, filtered and dry Et2O added to crystallise the hydrochloride salt (hygroscopic), m 113o. The free base can be obtained by suspending the salt in Et2O and adding small volumes of saturated aqueous K2CO3 until effervescence is complete and the mixture is distinctly alkaline. At this stage the aqueous layer should appear as a white sludge. The mixture is heated to boiling and refluxed for 30minutes (more Et2O is added if necessary). Purification of Biochemicals — Amino Acids and Peptides The Et2O layer is decanted off from the white sludge, the sludge is extracted twice with Et2O (by boiling for a few minutes), the combined organic layers are dried (KOH pellets), evaporated and the residue is distilled in a vacuum. [Nagao et al. J Org Chem 55 1148 1990, Beilstein 4 III 805.]
L-2-Amino-3-methylbutan-1-ol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
L-2-Amino-3-methylbutan-1-ol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 499)Lieferanten
2026-48-4(L-2-Amino-3-methylbutan-1-ol)Verwandte Suche:
- (+)-L-VALINOL
- L-(+)-VALINOL
- H-VALINOL
- H-L-VAL-OL
- (2S)-2-AMINO-3-METHYL-BUTAN-1-OL
- L-Valinol ,98%
- (S)-2-Isopropyl-2-aminoethanol
- (S)-(+)-2-Amino-3-methyl-1-butanol,96%
- L-Valinol ,98% [ee: 95%]
- L-Valinol ,95%
- (S)-(+)-2-Amino-3-me
- L-Valino
- (S)-(+)-2-AMino-3-Methyl-1-butanol, 96% 1ML
- (S)-(+)-2-AMINO-3-METHYL-1-BUTANOL FOR S
- (S)-(+)-2-Amino-3-methyl-1-butanol(L-Valinal)
- L-Valinol, 98%, ee: 95%
- PKC PharMaceuticals, Inc.
- L - valerian aMMonia alcohol
- L-(+)-Valinol (S)-(+)-2-Amino-3-methyl-1-butanol L-2-Amino-3-methylbutan-1-ol
- (S)-(+)-2-Amino-3-methyl-1-butanol 96%
- L-Valinol Free Base
- L-Valinol, ee: 95%
- L-Valinol≥ 98% (GC)
- L-Valinol,99%e.e.
- L-Valinol,Elvitegravir intermediate
- 1-Butanol, 2-amino-3-methyl-, (S)-
- (S)-(+)-2-Amino-3-methyl-1-butanol~H-Val-ol
- Valinol,97%
- (R)-(+)-2-Amino-3-methyl-1-butanolL-Valanol
- L-Valinol(S)-(+)-2-Amino-3-methyl-1-butanol
- L-Valanol
- (S)-(+)-2-AMINO-3-METHYL-1-BUTANOL, 96% (95% EE/GLC)
- L-Val-ol
- (S)-2-AMINO-3-METHYL-1-BUTANOL 98.0%
- 1-Butanol, 2-amino-3-methyl-, (2S)-
- (S)-2-AMINO-3-METHYL-L-BUTANOL
- (S)-(+)-2-AMINO-3-METHYL-BUTANOL
- (S)-2-AMINO-3-METHYL-BUTAN-1-OL
- (S)-(+)-2-AMINO-3-METHYL-1-BUTANOL
- S-(-)-2-AMINO-3-METHYL-1-BUTANOL
- H-Val-ol
(S)-(+)-2-Amino-3-methyl-1-butanol)
- -(+)-VaL
- (S)-(+)-2-Amino-3-methyl-1-butanol USP/EP/BP
- L-VALINAL
- L-VALINOL
- L-2-AMINO-3-METHYL-1-BUTANOL
- l-2-amino-3-methylbutan-1-ol
- H-VAL-OL
- S-VALINOL
- (S)-2-AMINO-3-METHYL-1-BUTANOL
- M0
- AMG-232-008
- (+)-Valinol
- val-ol
- 2026-48-4
- 2046-48-4
- 226-48-4
- AMINE
