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FLUTOLANIL

FLUTOLANIL
FLUTOLANIL structure
CAS No.
66332-96-5
Chemical Name:
FLUTOLANIL
Synonyms
MONCUT;NNF 136;MONCUT(R);Flutalanil;FLUTOLANIL;Flutolanil 0.1;FLUTOLANIL STANDARD;FLUTOLANIL, 250MG, NEAT;Flutolanil Solution, 1000ppm;Flutolanil @100 μg/mL in MeOH
CBNumber:
CB9478268
Molecular Formula:
C17H16F3NO2
Formula Weight:
323.31
MOL File:
66332-96-5.mol

FLUTOLANIL Properties

Melting point:
108° (Araki, Yabutani); mp 104-105° (Araki, 1985)
Boiling point:
339.1±42.0 °C(Predicted)
Density 
1.2463 (estimate)
vapor pressure 
6.5 x 10-6 Pa (25 °C)
storage temp. 
0-6°C
Water Solubility 
6.53 mg l-1 (20 °C)
pka
12.44±0.70(Predicted)
FDA UNII
2USL6Y9JZ4
Pesticides: Freedom of Information Act (FOIA)
Flutolanil
EPA Substance Registry System
Flutolanil (66332-96-5)
SAFETY
  • Risk and Safety Statements
RTECS  CV5581320
Toxicity LD50 in male and female rats, male and female mice (mg/kg): >10,000, >10,000 orally; in male and female rats (mg/kg): >5000 dermally (Araki)

FLUTOLANIL Chemical Properties,Uses,Production

Uses

Agricultural fungicide.

Uses

Flutolanil is used to control Basidiomycetes diseases in rice, cereals, sugar beet and other crops.

Safety Profile

Low toxicity by ingestion, skincontact, intraperitoneal, and subcutaneous routes. Whenheated to decomposition it emits toxic vapors of NOx andF??.

Metabolic pathway

Flutolanil is an analogue of mepronil in which the methyl group is replaced by trifluoromethyl. Both compounds have systemic activity. This change in structure should render flutolanil more biostable by hindering hydrolysis and removing the option of methyl hydroxylation and further oxidation. This seems to be borne out in practice in that most of the metabolism of flutolanil occurs via O-dealkylation and aryl hydroxylation. Hydrolysis has not been detected.

Degradation

Flutolanil is a stable arylamide with no particularly weak link in its comparatively simple chemistry. It is stable over the pH range 3-11 and it is stable to heat (PM). It is stable in sunlight (PM) but it was slowly degraded in 50% aqueous ethanol solution irradiated with a high pressure mercury lamp whilst bubbling oxygen through the solution (Tsao and Eto, 1991). The study was conducted using non-radiolabelled compound. No degradation occurred in the absence of oxygen. Even under these conditions, the addition of photosensitisers was required to give a reasonable amount of breakdown. With 5% acetone in the solution, 20% degradation was obtained in 8 hours. Almost no decomposition occurred on a glass surface in 8 hours unless a sensitiser (e.g. benzophenone) was added. This gave 40% decomposition.
The products in solution and on surfaces were different, as shown in Scheme 1. The major product (80%) in solution was 2-(trifluoromethyl)- benzamide (2). The benzoic acid (3) was identified as a minor product. The N-ethoxycarbonyl derivative (4) was due to reaction with the solvent. Amide bond cleavage was postulated to occur via oxidation in the aniline ring (Tsao and Eto, 1991; Yumita et al., 1984). The resulting phenolic products and anilines were converted into unidentified polar polymers.
No product 2 was obtained by irradiation on a glass surface (Tsao and Eto, 1991). Under these conditions 3'-hydroxy-2-(trifluoromethyl)benzanilide (5), i.e. dealkylated flutolanil, and a rearrangement product (6) were the main products. Flutolanil is therefore an extremely stable compound which undergoes slow photo-oxidation rather than aqueous photolysis.

FLUTOLANIL Preparation Products And Raw materials

Raw materials

Preparation Products


FLUTOLANIL Suppliers

Global( 67)Suppliers
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