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COMBRETASTATIN A-4

COMBRETASTATIN A-4
COMBRETASTATIN A-4 structure
CAS No.
117048-59-6
Chemical Name:
COMBRETASTATIN A-4
Synonyms
CA4;CS-A4;CS-284;CRC 87-09;Combrestatin A4;CoMbretastatin A;Combretastatin A4;(Z)-CombretastatinA4;Combretastatin A4 >CA-4, Combretastatin A-4
CBNumber:
CB9496826
Molecular Formula:
C18H20O5
Formula Weight:
316.35
MOL File:
117048-59-6.mol

COMBRETASTATIN A-4 Properties

Melting point:
84.5-85.5°C
Boiling point:
490.3±45.0 °C(Predicted)
Density 
1.184±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: >10mg/mL
pka
9.65±0.10(Predicted)
form 
powder
color 
off-white
Merck 
14,2494
FDA UNII
16U6OP69RQ
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS05,GHS06
Signal word  Danger
Hazard statements  H301+H311+H331-H318
Precautionary statements  P261-P280-P301+P310-P305+P351+P338-P311
Hazard Codes  T
Risk Statements  23/24/25-41
Safety Statements  26-36/37-39-45
RIDADR  UN 2811
WGK Germany  2
HazardClass  6.1
PackingGroup 
HS Code  29095000

COMBRETASTATIN A-4 price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C7744 Combretastatin A4 ≥98% (HPLC), powder 117048-59-6 5mg $97.6 2021-12-16 Buy
Sigma-Aldrich 234200 Combretastatin A-4 117048-59-6 10mg $173.9 2021-12-16 Buy
TCI Chemical C2520 Combretastatin A4 >98.0%(HPLC) 117048-59-6 25mg $244 2021-12-16 Buy
TCI Chemical C2520 Combretastatin A4 >98.0%(HPLC) 117048-59-6 250mg $1353 2021-12-16 Buy
Cayman Chemical 10007412 Combrestatin A4 ≥98% 117048-59-6 5mg $50 2021-12-16 Buy

COMBRETASTATIN A-4 Chemical Properties,Uses,Production

Description

Combrestatin A4 (CA4) is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. Combrestatin A4 was shown to inhibit tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma), and MCF-7 (breast cancer) with IC50 values of 2.16, 5.20, 3.46, and 18.47 nM, respectively. CA4 inhibits tubulin polymerization with an IC50 value of 2.2 μM.

Chemical Properties

Crystalline Powder

Uses

Combretastatin is a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. A potent cytotoxic agent which strongly inhibits the polymerization of tubulin by binding to the colchicine site.

Biological Activity

Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo . Acts by inhibiting tubulin polymerization (IC 50 = 2-3 μ M).

Anticancer Research

It is a stilbenoid compound and the active among all combretastatins isolated fromthe bark of Combretum caffrum and is used for colon, lung, and leukemia cancertherapy (Shoeb 2006).

COMBRETASTATIN A-4 Preparation Products And Raw materials

Raw materials

Preparation Products


COMBRETASTATIN A-4 Suppliers

Global( 226)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3013 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Zhejiang ZETian Fine Chemicals Co. LTD
18957127338
stella@zetchem.com China 2008 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com China 2712 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Xi'an Kono chem co., Ltd.,
13289246953 029-86107037
info@konochemical.com CHINA 3000 58
NanJing Spring & Autumn Biological Engineering CO., LTD.
0086 13815430202 0086 13815430202
sale02@cqherb.com CHINA 376 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58

View Lastest Price from COMBRETASTATIN A-4 manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-17 Combretastatin A4 117048-59-6
117048-59-6
US $17.00 / mg 20mg ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2021-11-02 Combretastatin A4
117048-59-6
US $390.00 / g 1g 99% 1kg Baoji Guokang Healthchem co.,ltd
2021-07-02 COMBRETASTATIN A-4
117048-59-6
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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