Pamidronate disodium salt
- CAS No.
- 57248-88-1
- Chemical Name:
- Pamidronate disodium salt
- Synonyms
- cgp23339a;PAMIDRONATE;CGP 23339AE;PAMIDRONICDISODIUMSALT;PaMidronate DisodiuM API;Pamidronate disodium salt;Disodium Pamidronate Pamidronate (sodium salt);Disodium Pamidronate Hydrate;Pamidronate disodium hydrate
- CBNumber:
- CB9707409
- Molecular Formula:
- C3H12NNaO7P2
- Molecular Weight:
- 259.07
- MDL Number:
- MFCD01938386
- MOL File:
- 57248-88-1.mol
- MSDS File:
- SDS
Melting point | 300 °C |
---|---|
storage temp. | 2-8°C |
solubility | H2O: 28 mg/mL |
form | solid |
color | white |
Merck | 14,7003 |
Stability | Hygroscopic |
CAS DataBase Reference | 57248-88-1(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | C7S8VWP5DH |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H319 | |||||||||
Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 22-48-41-37/38-20/21/22 | |||||||||
Safety Statements | 22-26-36/37/39-45 | |||||||||
RIDADR | 3077 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | SZ6525000 | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29319090 | |||||||||
NFPA 704 |
|
Pamidronate disodium salt price More Price(43)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | P2371 | Pamidronate disodium salt hydrate ≥95% (NMR), solid | 57248-88-1 | 10mg | $133 | 2024-03-01 | Buy |
Sigma-Aldrich | P2371 | Pamidronate disodium salt hydrate ≥95% (NMR), solid | 57248-88-1 | 100mg | $616 | 2024-03-01 | Buy |
Sigma-Aldrich | BP615 | Disodium pamidronate British Pharmacopoeia (BP) Reference Standard | 57248-88-1 | 100MG | $259 | 2023-06-20 | Buy |
TCI Chemical | D3921 | Disodium Pamidronate Hydrate >97.0%(T) | 57248-88-1 | 100mg | $52 | 2024-03-01 | Buy |
TCI Chemical | D3921 | Disodium Pamidronate Hydrate >97.0%(T) | 57248-88-1 | 1g | $302 | 2024-03-01 | Buy |
Pamidronate disodium salt Chemical Properties,Uses,Production
Description
Disodium pamidronate is a calcium metabolism regulator useful in the treatment of hypercalcemia associated with malignancy. It presumably reduces the bone resorption of calcium by inhibiting the formation and attachment of osteoclasts. Other potential uses include osteoporosis and calcitonin-resistant Paget’s disease.
Chemical Properties
White Crystals
Originator
Henkel (United Kingdom)
Uses
A farnesyl diphosphate synthase inhibitor
Uses
Pamidronate disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis. It is used to prevent bone loss, and treat osteoporosis.
Uses
A bisphosphonate antiresorptive agent; bone resorption inhibitor.
Manufacturing Process
For a batch size of 5 L, 587.5 g (3.2 moles) of mannitol is dissolved in 3.5 L of water. Pamidronic acid (31.6 g, 0.133 moles) is mixed with a 1.0 L aliquot of the mannitol solution to form a slurry. The slurry is then transferred into the remainder of the mannitol solution, and stirred for at least 15 min. Aqueous 1 N sodium hydroxide (270 ml) is then added and the mixture is stirred until a clear, colorless solution results. The pH is then adjusted to 6.50.1 using either 1 M aqueous phosphoric acid or 1 N aqueous sodium hydroxide, as needed. The solution is then filtered through a 0.22 micron filter, and filled at 20°C into vials at 4.0 ml (4.172 g)/vial, under sterile conditions. The aqueous solution is frozen at -37°C and lyophilized (20 mbar, 20°-40°C) to yield 1,250 vials, each containing 30 mg of amorphous disodium pamidronate. The vials are sealed under positive nitrogen pressure. The disodium pamidronate is amorphous (noncrystalline) by X-ray diffraction and contains 0.7 wt-% water.
brand name
Aredia (Novartis).
Therapeutic Function
Bone resorption suppressant
Biochem/physiol Actions
Pamidronate disodium?has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.
Veterinary Drugs and Treatments
Pamidronate may be useful in treating hypercalcemia associated with vitamin D-related toxicoses or hypercalcemia of malignancy. There is ongoing research on the use of this drug to determine if it has clinical usefulness in directly treating “micro-metastases” in osteosarcomas.
Pamidronate disodium salt Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 2263 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29067 | 58 |
AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
View Lastest Price from Pamidronate disodium salt manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-07-29 | Pamidronate disodium salt USP/EP/BP
57248-88-1
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | ||
2021-07-13 | Pamidronate disodium salt
57248-88-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2021-07-10 | Pamidronate disodium salt
57248-88-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
- Pamidronate disodium salt USP/EP/BP
57248-88-1
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
- Pamidronate disodium salt
57248-88-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- Pamidronate disodium salt
57248-88-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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