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アジスロマイシン

アジスロマイシン 化学構造式
83905-01-5
CAS番号.
83905-01-5
化学名:
アジスロマイシン
别名:
アジスロマイシン二水和物標準品;アジスロマイシン;アジトロマイシン
英語化学名:
Azithromycin
英語别名:
Zeto;xz405;Tobil;Zifin;XZ-450;Azenil;Azimin;Aziwok;Aztrin;Setron
CBNumber:
CB1442887
化学式:
C38H72N2O12
分子量:
748.98
MOL File:
83905-01-5.mol

アジスロマイシン 物理性質

融点 :
113-115°C
比旋光度 :
D20 -37° (c = 1 in CHCl3)
貯蔵温度 :
Store at -20°C
溶解性:
Practically insoluble in water, freely soluble in anhydrous ethanol and in methylene chloride.
外見 :
neat
酸解離定数(Pka):
pKa 8.74 (H2O t=25 I=0.167) (Uncertain);9.45(H2O t=25 I=0.167) (Uncertain)
光学活性 (optical activity):
[α]/D 45±2°, c = 1% in ethanol
安定性::
Stable. Incompatible with strong oxidizing agents.
CAS データベース:
83905-01-5(CAS DataBase Reference)
EPAの化学物質情報:
1-Oxa-6-azacyclopentadecan- 15-one, 13-[(2,6-dideoxy-3-C-methyl- 3-O-methyl-.alpha.-L-ribo- hexopyranosyl)oxy]-2-ethyl- 3,4,10-trihydroxy-3,5,6,8, 10,12,14-heptamethyl-11-[[ 3,4,6-trideoxy-3-(dimethylamino)-. beta.-D-xylo-hexopyranosyl] oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S, 13S,14R)-(83905-01-5)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xi,Xn
Rフレーズ  42/43
Sフレーズ  22-36/37-45
WGK Germany  2
RTECS 番号 RN6960000
HSコード  29419090
有毒物質データの 83905-01-5(Hazardous Substances Data)
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H317 アレルギー性皮膚反応を起こすおそれ 感作性、皮膚 1 警告 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 吸入するとアレルギー、喘息または、呼吸困難 を起こすおそれ 感作性、呼吸器 1 危険 P261, P285, P304+P341, P342+P311,P501
注意書き
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P284 呼吸用保護具を着用すること。
P304+P340 吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。
P342+P311 呼吸に関する症状が出た場合:医師に連絡すること。

アジスロマイシン 価格 もっと(5)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC3771 アジスロマイシン
Azithromycin
83905-01-5 50mg ¥30000 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01LKTA9834 アジトロマイシン
Azithromycin
83905-01-5 5g ¥62400 2018-12-26 購入
関東化学株式会社(KANTO) 49860-80 アジスロマイシン二水和物標準品
Azithromycin dihydrate standard
83905-01-5 50mg ¥38000 2018-12-13 購入
Sigma-Aldrich Japan 75199 アジスロマイシン analytical standard
Azithromycin analytical standard
83905-01-5 25mg-f ¥43400 2018-12-25 購入
Sigma-Aldrich Japan 1046067 United States Pharmacopeia (USP) Reference Standard
Azithromycin Identity United States Pharmacopeia (USP) Reference Standard
83905-01-5 75mg ¥223800 2018-12-25 購入

アジスロマイシン MSDS


Azithromycin

アジスロマイシン 化学特性,用途語,生産方法

用途

マクロライド系抗生物質です。

効能

抗生物質, タンパク質合成阻害薬

説明

Azithromycin is a long-acting macrolide antibiotic structurally related to erythromycin A (EA), having a methyl-substituted nitrogen at position 9a in the aglycone ring. Azithromycin is reported to be highly effective in the treatment of respiratory and urinary infections; it has the advantages of being acid-stable and requiring a shorter course of treatment than EA.

化学的特性

White Crystalline Powder

Originator

Pliva (Yugoslavia)

使用

Labelled Azithromycin, a semi-synthetic macrolide antibiotic; related to Erythromycin A. Antibacterial.

使用

Azithromycin is a semi-synthetic, ring-expanded erythromycin, produced by a Beckmann rearrangement of erythromycin oxime and reduction to the imine ether, followed by reductive methylation. Azithromycin was the first of the azalides and was designed to improve stability and biological half-life of erythromycin A, as well as improve activity against Gram negative bacteria. Since its discovery in 1980 by Djokic and co-workers, azithromycin has enjoyed considerable therapeutic success.

使用

Cephalosporin antibiotic

使用

Azithromycin is a semi-synthetic, ring-expanded erythromycin produced by a Beckmann rearrangement of erythromycin oxime and reduction to the imine ether, followed by reductive methylation. Azithromycin was the first of the azalides and was designed to improve the stability and biological half-life of erythromycin A, as well as improve activity against Gram negative bacteria. Since its discovery in 1980 by Djokic and co-workers, azithromycin has enjoyed considerable therapeutic success.

使用

Labeled Azithromycin, Intended for use as an internal standard for the quantification of Azithromycin by GC- or LC-mass spectrometry

定義

ChEBI: A macrolide antibiotic useful for the treatment of bacterial infections.

brand name

Zithromax (Pfizer); Zmax (Pfizer);Sunamed.

抗菌性

It is less potent than erythromycin A against Gram-positive isolates, but is more active against Gram-negative bacteria. It is four times more potent than erythromycin A against H. influenzae, N. gonorrhoeae and Campylobacter spp., and twice as active against Mor. catarrhalis. It also exhibits superior potency against Enterobacteriaceae, notably Esch. coli, Salmonella enterica serotypes, and Shigella spp. It is active against Mycobacteria, notably the M. avium complex and against intracellular micro-organisms such as Legionella and Chlamydia spp.
Chemical modification at the 9 position of the erythronolide A ring of erythromycin A blocks the internal ketalization and markedly improves acid stability. At pH 2, loss of 10% activity occurred in less than 4 s with erythromycin A, but took 20 min with azithromycin. The AUC at 0–24 h is 4.5 mg.h/L. The level is only slightly increased on repeated dosing.
Binding to plasma protein varies with the concentration, from around 50% at 0.05 mg/L to 7.1% at 1 mg/L. The apparent elimination half-life is dependent upon sampling interval: between 8 and 24 h it ranged from 11 to 14 h; between 24 and 72 h it was 35–40 h.
It rapidly penetrates the tissues, reaching levels that approach or, in some cases, exceed the simultaneous plasma levels and persist for 2–3 days. Only about 6% of the dose is found in urine in the first 24 h.

一般的な説明

The spectrum of antimicrobial activity of azithromycin issimilar to that observed for erythromycin and clarithromycinbut with some interesting differences. In general,it is more active against Gram-negative bacteria and less activeagainst Gram-positive bacteria than its close relatives.The greater activity of azithromycin against H. influenzae,M. catarrhalis, and M. pneumoniae coupled with its extendedhalf-life permits a 5-day dosing schedule for thetreatment of respiratory tract infections caused by thesepathogens. The clinical efficacy of azithromycin in the treatmentof urogenital and other sexually transmitted infectionscaused by Chlamydia trachomatis, N. gonorrhoeae, H.ducreyi, and Ureaplasma urealyticum suggests that singledosetherapy with it for uncomplicated urethritis or cervicitismay have advantages over use of other antibiotics.

応用例(製薬)

A semisynthetic derivative of erythromycin A, supplied as the dihydrate for oral administration.

生物活性

Macrolide antibiotic. Inhibits 50S ribosomal subunit formation and elongation at transpeptidation step in gram-positive and gram-negative organisms. Orally active with improved pharmacokinetics over erythromycin in mouse models.

薬物動態学

Oral absorption:37%
Cmax 250 mg oral: 0.17 mg/L after 2.2 h
500 mg oral: 0.4 mg/L after2h
Plasma half-life (terminal): 11–40 h
Volume of distribution: 31 L/kg
Plasma protein binding :7–50%
Chemical modification at the 9 position of the erythronolide A ring of erythromycin A blocks the internal ketalization and markedly improves acid stability. At pH 2, loss of 10% activity occurred in less than 4 s with erythromycin A, but took 20 min with azithromycin. The AUC at 0–24 h is 4.5 mg.h/L. The level is only slightly increased on repeated dosing.
Binding to plasma protein varies with the concentration, from around 50% at 0.05 mg/L to 7.1% at 1 mg/L. The apparent elimination half-life is dependent upon sampling interval: between 8 and 24 h it ranged from 11 to 14 h: between 24 and 72 h it was 35–40 h.
It rapidly penetrates the tissues, reaching levels that approach or, in some cases, exceed the simultaneous plasma levels and persist for 2–3 days. Only about 6% of the dose is found in urine in the first 24 h.

副作用

Azithromycin is well tolerated with little gastrointestinal disturbance.

アジスロマイシン 上流と下流の製品情報

原材料

準備製品


アジスロマイシン 生産企業

Global( 349)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 661 60
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24001 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21968 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 541 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1730 55

83905-01-5(アジスロマイシン)キーワード:


  • 83905-01-5
  • -l-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamet
  • xz405
  • AZYTHROMYCIN
  • Azithromycin CP2000 USP24
  • AZITHROMYCIN IMPURITY A6-DEMETHYLAZITHROMYCIN EP STANDARD
  • AZITHROMYCIN IMPURITY B3-DEOXYAZITHROMYCIN EP STANDARD
  • AZITHROMYCIN USP STANDARD
  • AZITHROMYCIN DIHYDRATE(COMPACTED)
  • Azithromycin(Dihydrate)Usp27
  • Azitrocin
  • Ribotrex
  • Sumamed
  • Trozocina
  • XZ-450
  • Zithromaz
  • Zitromax
  • 1-Oxa-6-azacyclopentadecan-15-one, 13-(2,6-dideoxy-3-C-methyl-3-O-methyl-.alpha.-L-ribo-hexopyranosyl)oxy-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-3,4,6-trideoxy-3-(dimethylamino)-.beta.-D-xylo-hexopyranosyloxy-, (2R,3S,4R,5R,8R,10R,11R,1
  • 4''-EPL-9-DEOXO-9A-METHYL-9A-ASN-9A-HOMOERY-THROMYCIN/AZITHROMYCIN
  • AZITHROMYCIN/4''-EPI-9-DEOXO-9A-METHYL-9A-AZA-9A-HOMOERY-THROMYCINA/AZITHROMYCIN
  • water soluble azithromycin70%
  • 4"-Epi-9-deoxo-9α-methyl-9α-aza-9α-homoerythromycin A
  • Surnamed
  • Zitroroax
  • (2R,3R,4R,5R,8R,10R,11R,13S,14R)-11-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2S,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
  • (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentade
  • (2R,3S,4R,5R,8R,10R,11R,13S,14R)-11-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
  • 13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one
  • AzithroMycin Identity
  • AzithroMycin (ZithroMax)
  • AzithroMycin API
  • アジスロマイシン二水和物標準品
  • アジスロマイシン
  • アジトロマイシン
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