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ビタミン K1

ビタミン K1 化学構造式
84-80-0
CAS番号.
84-80-0
化学名:
ビタミン K1
别名:
ビタミン K1;2-メチル-3-フィチル-1,4-ナフトキノン;フィトナジオン;フィロキノン;ビタミンK1(フィトナジオン);フィロキノン標準品(異性体混合物);ビタミンK1 溶液;フィトメナジオン;ビタミン K1【フィトナジオン】;フィトナジオン (JP17)
英語化学名:
Vitamin K1
英語别名:
kativn;K-Ject;Kaywan;Orakay;Kephton;2',3'-t;Kativ N;Veda K1;Veta K1;K1VitaM
CBNumber:
CB3482555
化学式:
C31H46O2
分子量:
450.7
MOL File:
84-80-0.mol

ビタミン K1 物理性質

融点 :
−20 °C(lit.)
比旋光度 :
D25 -0.28° (dioxane)
沸点 :
140°C 0mm
比重(密度) :
0.984 g/mL at 25 °C(lit.)
屈折率 :
n20/D 1.527(lit.)
闪点 :
>230 °F
貯蔵温度 :
2-8°C
外見 :
viscous liquid
比重:
0.984
水溶解度 :
Miscible with dehydrated alcohol, acetone, petroleum ether, hexane, dioxane, chloroform, ether, benzene and vegetable oils. Immiscible with water.
Sensitive :
Light Sensitive
Merck :
14,7380
BRN :
2568816
InChIKey:
MBWXNTAXLNYFJB-LKUDQCMESA-N
CAS データベース:
84-80-0(CAS DataBase Reference)
NISTの化学物質情報:
Phytonadione(84-80-0)
EPAの化学物質情報:
Phylloquinone (84-80-0)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xi
Rフレーズ  36/37/38
Sフレーズ  26-37/39-24/25
RIDADR  UN1170 - class 3 - PG 2 - Ethanol, solution
WGK Germany  2
RTECS 番号 QJ5800000
1-8-10
TSCA  Yes
HSコード  29362900
有毒物質データの 84-80-0(Hazardous Substances Data)
消防法 危-4-3-III
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P337+P313 眼の刺激が続く場合:医師の診断/手当てを受けること。
P403+P235 換気の良い場所で保管すること。涼しいところに 置くこと。

ビタミン K1 価格 もっと(31)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00022815 ビタミンK1(フィトナジオン)
Vitamin K1(Phytonadione)
84-80-0 250mg ¥5500 2020-09-21 購入
富士フイルム和光純薬株式会社(wako) W01ACSVIT-016N ビタミンK1
Vitamin K1
84-80-0 100mg ¥7400 2021-03-23 購入
東京化成工業 P0642 ビタミンK1 >98.0%(E)
Vitamin K1 >98.0%(E)
84-80-0 5g ¥9700 2021-03-23 購入
関東化学株式会社(KANTO) 44060-60 ビタミンK1 >98.0%(UV‐VIS)
Vitamin K1 >98.0%(UV‐VIS)
84-80-0 1g ¥3100 2021-03-23 購入
Sigma-Aldrich Japan 47773 analytical standard
Phylloquinone (K1) analytical standard
84-80-0 100 mg ¥5600 2021-03-23 購入

ビタミン K1 化学特性,用途語,生産方法

外観

黄色~赤みの黄色, 澄明の液体

定義

本品は、次の化学式で表されるナフトキノン誘導体である。

溶解性

水に不溶, エタノール, エーテルに可溶。

用途

ビタミン K1 化合物です。

用途

HPLCによるビタミンK1測定用標準品。

化粧品の成分用途

皮膚コンディショニング剤

効能

低プロトロンビン血症治療薬, 止血薬, ビタミンK1補充薬

商品名

カチーフ (日本製薬); ケーワン (エーザイ)

化学的特性

Yellow Oil

化学的特性

Phylloquinone is an odorless yellow viscous oil or crystals.

Originator

Mephyton ,MSD ,US ,1941

使用

vitamin K1

使用

Labeled Phytonadione, intended for use as an internal standard for the quantification of Phytonadione by GC- or LC-mass spectrometry.

使用

Occurs widely in green plants, algae, photosynthetic bacteria.

Manufacturing Process

11 parts by weight of 2-methyl-1,4-naphthohydroquinone, 30 parts by volume of water-free dioxane and 1.5 parts by volume of boron trifluoride etherate are heated to 50°C. While agitating and introducing nitrogen, 10 parts by weight of phytol dissolved in 10 parts by volume of dioxane are added in the course of 15 minutes. Thereupon, the dark colored reaction mixture is stirred for 20 additional minutes at 50°C, cooled down and 60 parts by volume of ether are added. The reaction mixture is washed first with water, then with a mixture of 3 parts of N-sodium hydroxide and 2 parts of a 2.5% solution of sodium hydrosulfite and again with water. The aqueous extracts are washed with ether. The ether solutions are collected, dried over sodium sulfate and concentrated, toward the end under reduced pressure.
The waxlike condensation product so obtained is mixed with 60 parts by volume of petroleum ether (boiling limits 30°C to 40°C) and agitated with hydrogen in the presence of a little active palladium lead catalyst (Pd-CaCO3catalyst, the activity of which is reduced by the addition of lead and quinoline). During the operation, the condensation product separates in the form of a voluminous white precipitate. The latter is separated by filtration in the absence of air while adding an inert coarse-grained adsorption agent (for example, aluminum silicate salt for filter purposes), and washed with cooled petroleum ether. Thereupon, the 2-methyl-3-phytyl-1,4-naphthohydroquinone is extracted from the filter cake by means of ether, the ethereal solution is concentrated to 100 parts by volume and the reaction product is oxidized by stirring the solution with 6.6 parts by weight of silver oxide during 30 minutes. The solution is filtered through sodium sulfate, the latter is rinsed with ether and the solvent is evaporated. There are obtained 5.7 parts by weight of 2-methyl-3-phytyl-1,4-naphthoquinone (vitamin K1) in the form of a golden yellow oil.

Therapeutic Function

Prothrombogenic vitamin

職業ばく露

Phylloquinone is a dietary component essential for normal biosynthesis of several factors required for clotting of blood; as a therapeutic drug used to correct bleeding tendency; and as a food supplement.

Veterinary Drugs and Treatments

The principal uses of exogenously administered phytonadione is in the treatment of anticoagulant rodenticide toxicity. It is also used for treating dicumarol toxicity associated with sweet clover ingestion in ruminants, sulfaquinoxaline toxicity, and in bleeding disorders associated with faulty formation of vitamin K-dependent coagulation factors.

輸送方法

UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

純化方法

Vitamin K1 is a yellow viscous oil, which can be distilled at high vacuum practically unchanged. It is insoluble in H2O, but soluble in common organic solvents. Store it in the dark under N2 as it is oxygen sensitive. It has  1cm 328 at 248nm. [Fieser et al. J Am Chem Soc 61 2557 1939, Hirschmann et al. J Am Chem Soc 76 4592 1954, Isler & Doebel Helv Chim Acta 27 225 1954, Beilstein 7 IV 2496.]

不和合性

Phylloquinone is photosensitive; decomposes in sunlight and is destroyed by alkali hydroxides and reducing agents such as hydrideds and active metals. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

廃棄物の処理

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

ビタミン K1 上流と下流の製品情報

原材料

準備製品


ビタミン K1 生産企業

Global( 437)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 743 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20914 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26751 60
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58

84-80-0(ビタミン K1)キーワード:


  • 84-80-0
  • Kativn K1
  • Phytomenadione (Vitamin K1)
  • vitamin K1 micro-capsule
  • PHYLLOQUINONE
  • PHYTOMENADIONE
  • PHYTONADIONE
  • kativn
  • Kephton
  • Kinadion
  • K-Ject
  • Konakion
  • Mephyton
  • Monodion
  • Mono-Kay
  • Phyllochinon
  • Phythyl-menadion
  • Phytylmenadione
  • Synthex P
  • synthexp
  • theta-(e)]]-a-[thet
  • trans-Phylloquinone
  • Vitamin K1 1% powder
  • phylloguinone
  • PHYTONADIONE (PHYLLOQUINONE)
  • VITAMIN K1 (NATURAL) (USP) (PHYTONADIONE)
  • Vitamin K1(>99.5%Cis-K1<1.0%)
  • Vitamin K1(>99.5%Cis-K1<5.0%)
  • 2-Methyl-3-phytyl-1,4-naphthoquinone, 3-Phytylmenadione, Phylloquinone, VitaminK1(20), VitaminK1
  • 2-Methyl-3-phytyl-1,4-naphthoquinone, 3-Phytylmenadione, Phylloquinone, VitaminK1(20)
  • Vitamin K1 Oll [Phyto (Me) Nadione (Phylloguinone)]
  • ビタミン K1
  • 2-メチル-3-フィチル-1,4-ナフトキノン
  • フィトナジオン
  • フィロキノン
  • ビタミンK1(フィトナジオン)
  • フィロキノン標準品(異性体混合物)
  • ビタミンK1 溶液
  • フィトメナジオン
  • ビタミン K1【フィトナジオン】
  • フィトナジオン (JP17)
  • 生化学
  • ビタミン
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