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フルオキセチン塩酸塩

フルオキセチン塩酸塩 化学構造式
56296-78-7
CAS番号.
56296-78-7
化学名:
フルオキセチン塩酸塩
别名:
プロザック;フルオキセチン塩酸塩;ホンテックス;3-[p-(トリフルオロメチル)フェノキシ]-N-メチル-3-フェニルプロパン-1-アミン·塩酸塩;N-メチル-γ-[4-トリフルオロメチルフェノキシ]ベンゼン-1-プロパンアミン·塩酸塩;N-メチル-3-フェニル-3-[4-(トリフルオロメチル)フェノキシ]プロピルアミン塩酸塩;(±)-フルオキセチン塩酸塩;フルオクセチン塩酸塩;フルオキセチン 塩酸塩;フルオキセチン塩酸塩 (JAN);塩酸フルオキセチン
英語化学名:
Fluoxetine hydrochloride
英語别名:
fontex;Lovan-d;Lovan-d5;Zepax-d5;Adofen-d5;Fontex-d5;Ansilan-d5;Fluctin-d5;Foxetin-d5;Alzac 20-d5
CBNumber:
CB5298253
化学式:
C17H19ClF3NO
分子量:
345.79
MOL File:
56296-78-7.mol

フルオキセチン塩酸塩 物理性質

融点 :
158-159°C
比旋光度 :
-0.05~+0.05°
闪点 :
9℃
貯蔵温度 :
Store at RT
溶解性:
H2O: soluble (sparingly)
外見 :
solid
色:
white
水溶解度 :
Soluble in dimethylsulfoxide and water.
InChIKey:
GIYXAJPCNFJEHY-UHFFFAOYSA-N
CAS データベース:
56296-78-7(CAS DataBase Reference)
EPAの化学物質情報:
Fluoxetine hydrochloride (56296-78-7)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn,N
Rフレーズ  22-38-41-50
Sフレーズ  26-36/37/39-61-39
RIDADR  3249
WGK Germany  3
RTECS 番号 UI4050000
国連危険物分類  6.1(b)
容器等級  III
HSコード  29222990
有毒物質データの 56296-78-7(Hazardous Substances Data)
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H318 重篤な眼の損傷 眼に対する重篤な損傷性/眼刺激 性 1 危険 P280, P305+P351+P338, P310
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
H400 水生生物に強い毒性 水生環境有害性、急性毒性 1 警告 P273, P391, P501
注意書き
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P273 環境への放出を避けること。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P321 特別な処置が必要である(このラベルの... を見よ)。
P391 漏出物を回収すること。
P501 内容物/容器を...に廃棄すること。

フルオキセチン塩酸塩 価格 もっと(32)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01COBOR-1437
Fluoxetine, HCl
56296-78-7 5g ¥9000 2020-09-21 購入
富士フイルム和光純薬株式会社(wako) W01COBOR-1437
Fluoxetine, HCl
56296-78-7 1g ¥3600 2020-09-21 購入
東京化成工業 F0750 フルオキセチン塩酸塩 >98.0%(HPLC)(T)
Fluoxetine Hydrochloride >98.0%(HPLC)(T)
56296-78-7 5g ¥18100 2020-09-21 購入
東京化成工業 F0750 フルオキセチン塩酸塩 >98.0%(HPLC)(T)
Fluoxetine Hydrochloride >98.0%(HPLC)(T)
56296-78-7 1g ¥5900 2020-09-21 購入
Sigma-Aldrich Japan 1279804 フルオキセチン 塩酸塩 United States Pharmacopeia (USP) Reference Standard
Fluoxetine hydrochloride United States Pharmacopeia (USP) Reference Standard
56296-78-7 200mg ¥71100 2018-12-25 購入

フルオキセチン塩酸塩 化学特性,用途語,生産方法

外観

白色~ほとんど白色, 結晶性粉末~粉末

溶解性

メタノール、エタノール、アセトニトリル、クロロホルム、アセトンに可溶。酢酸エチル、水、ジクロロメタンにわずかに可溶。[メタノール85 + 水15(体積比)]に溶ける。

用途

薬理・生理作用研究用。

効能

抗うつ薬, 選択的セロトニン再取り込み阻害薬

説明

Fluoxetine hydrochloride is a serotonin-selective antidepressant approved for the treatment of major depressive disorders, including those with concomitant anxiety. It also appears effective in the treatment of obesity.

化学的特性

White to Off-White Powder

Originator

Lilly (USA)

使用

A labelled selective serotonin reuptake inhibitor (SSRI). Used as an antidepressant.

使用

A selective serotonin reuptake inhibitor (SSRI). Used as an antidepressant.

使用

A selectiive derotonin reuptake inhibitor. Used as an antidepressant

Manufacturing Process

About 600 g of β-dimethylaminopropiophenone hydrochloride were converted to the corresponding free base by the action of 1.5 N aqueous sodium hydroxide. Free base was dissolved in 2 L of THF, and the resulting solution added in dropwise fashion to a solution of 4 moles of diborane in 4 L of THF. The reaction mixture was stirred overnight. An additional mole of diborane in 1 L of THF was added, and the reaction mixture stirred again overnight. Next, 2 L of aqueous hydrochloric acid were added to decompose any excess diborane present. The tetrahydrofuran was removed by evaporation. The acidic solution was extracted twice with 1 L portions of benzene, and the benzene extracts were discarded. The acidic solution was then made basic with an excess of 5 N aqueous sodium hydroxide. The basic solution was extracted three times with 2 L portions of benzene. The combined extracts washed with a saturated aqueous sodium chloride and then dried. Evaporation of the solvent in vacuo yields 442 g of N,N-dimethyl-3-phenyl-3hydroxypropylamine.
A solution containing 442 g of N,N-dimethyl-3-phenyl-3-hydroxypropylamine in 5 L of chloroform was saturated with dry gaseous hydrogen chloride. 400 mL of thionyl chloride were then added to the solution at a rate sufficient to maintain reflux. The solution was refluxed an additional 5 hours. Evaporation of the chloroform and other volatile constituents in vacuo yielded N,Ndimethyl-3-phenyl-3-chloropropylamine hydrochloride which was collected by filtration, and the filter cake washed twice with 1.5 L portions of acetone. The washed crystals weighed about 500 g and melted at 181-183°C with decomposition. An additional 30 g of compound were obtained from the acetone wash by standard crystallization procedures. The structure of the above compound was verified by NMR and titration.
A solution of 50 g p-trifluoromethylphenol, 12 g of solid sodium hydroxide and 400 mL of methanol were added 29.8 g of N,N-dimethyl 3-phenyl-3chloropropylamine hydrochloride. The resulting reaction mixture was refluxed for about 5 days and then cooled. The methanol was removed by evaporation, and the resulting residue taken up in a mixture of ether and 5 N aqueous sodium hydroxide. The ether layer was separated and washed twice with 5 N aqueous sodium hydroxide and three times with water. The ether layer was dried, and the ether removed by evaporation in vacuo to yield as a residue N,N-dimethyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine.
To a solution 8.1 g of cyanogen bromide in 500 mL benzene and 50 mL of toluene at 5°C in nitrogen was added dropwise a solution of 12.146 g of N,Ndimethyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine in 40 mL of benzene. The temperature of the reaction mixture was allowed to rise slowly to room temperature, at which temperature stirring was continued overnight while still maintaining a nitrogen atmosphere. 100 mL of benzene were added. The reaction mixture was washed twice with water, once with 2 N aqueous sulfuric acid and then with water until neutral. The organic layer was dried, and the solvents removed therefrom by evaporation in vacuo to yield about 9.5 g of an oil comprising N-methyl-N-cyano-3-(p-trifluoromethylphenoxy)-3phenylpropylamine.
The reaction mixture containing 100 g potassium hydroxide, 85 mL water, 400 mL ethylene glycol and 9.50 g of N-methyl-N-cyano-3-(ptrifluoromethylphenoxy)-3-phenylpropylamine was heated to refluxing temperature for 20 hours, and was then cooled. 500 mL of water were added. The reaction mixture was extracted with three 500 mL portions of ether. The combined extracts washed with water. The water wash was discarded. The ether solution was next contacted with 2 N aqueous hydrochloric acid. The acidic aqueous layer was separated. A second aqueous acidic extract with 2 N hydrochloric acid was made followed by three aqueous extracts and an extract with saturated aqueous sodium chloride. The aqueous layers were all combined and made basic with 5 N aqueous sodium hydroxide. N-methyl 3(p-trifluoromethylphenoxy)-3-phenylpropylamine, formed in the above reaction, was insoluble in the basic solution and separated. The amine was extracted into ether. Two further ether extractions were carried out. The ether extracts were combined, and the combined extracts washed with saturated aqueous sodium chloride and then dried. Evaporation of the ether in vacuo yielded about 6.3 g of N-methyl-3-(p-trifluoromethylphenoxy)-3phenylpropylamine. The amine free base was converted to the corresponding hydrochloride salt.

brand name

Prozac (Lilly); Sarafem (Lilly); Sarafem (Warner Chilcott).

Therapeutic Function

Antidepressant

生物活性

Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a K i of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT 1A , 5-HT 2A , H 1 , α 1 , α 2 -adrenergic, and muscarinic receptors. Antidepressant. Also available as part of the Serotonin Uptake Inhibitor Tocriset™ .

フルオキセチン塩酸塩 上流と下流の製品情報

原材料

準備製品


フルオキセチン塩酸塩 生産企業

Global( 257)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 sales@frappschem.com China 886 50
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21734 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22622 55
PI & PI BIOTECH INC.
18371201331
020-81716319 Sales@pipitech.com CHINA 3048 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30025 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 309 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28230 58

56296-78-7(フルオキセチン塩酸塩)キーワード:


  • 56296-78-7
  • (+-)-methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanaminehydrochlorid
  • 3-(p-trifluoromethylphenoxy)-n-methyl-3-phenylpropylaminehydrochloride
  • Fluoxetine hydrochlorid
  • Fluoxetine hydrochloride
  • Methyl[3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]amine hydrochloride
  • N-Methyl-gama-[4-(trifluoromethyl)
  • Lovan-d5
  • N-methyl--[4-(trifluoromethyl)phenoxy]benzene-d5-propanamine Hydrochloride
  • N-methyl-3-phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine hydrochloride
  • Fluoxetine hydrochloride,(±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride, LY-110,140 hydrochloride, Prozac
  • N-Methyl-3-[(4-trifluoroMethyl)phenoxy]-3-phenylpropylaMine HCl
  • (S)-N-Methyl-3-(4-trifluoroMethylphenoxy)-3-(phenyl-d5)propylaMine Hydrochloride
  • (γS)-N-Methyl-γ-[4-(trifluoroMethyl)phenoxy](benzene-d5)propanaMine Hydrochloride
  • (+/-)-N-Methyl-3-(phenyl-d5)-3-[4-(trifluoroMethyl)phenoxy]propylaMine Hydrochloride
  • Affectine-d5
  • Alzac 20-d5
  • Ansilan-d5
  • Deproxin-d5
  • DigassiM-d5
  • Zepax-d5
  • Fluoxetine hcl API
  • fontex
  • lilly110140
  • n-methyl-3-phenyl-3-(p-trifluoromethylphenoxy)-propylaminhydrochloride
  • FLUOXETINE-D5 HCL
  • FLUOXETINE-D5 HCL (PHENYL-D5)
  • FLUOXETINE-D5 HYDROCHLORIDE
  • methyl[3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]ammonium chloride
  • (±)-N-methyl-γ-[4-(trifluoromethyl)phenoxy]-benzenepropanamine
  • Adofen-d5
  • プロザック
  • フルオキセチン塩酸塩
  • ホンテックス
  • 3-[p-(トリフルオロメチル)フェノキシ]-N-メチル-3-フェニルプロパン-1-アミン·塩酸塩
  • N-メチル-γ-[4-トリフルオロメチルフェノキシ]ベンゼン-1-プロパンアミン·塩酸塩
  • N-メチル-3-フェニル-3-[4-(トリフルオロメチル)フェノキシ]プロピルアミン塩酸塩
  • (±)-フルオキセチン塩酸塩
  • フルオクセチン塩酸塩
  • フルオキセチン 塩酸塩
  • フルオキセチン塩酸塩 (JAN)
  • 塩酸フルオキセチン
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