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ピリドキシン

ピリドキシン 化学構造式
65-23-6
CAS番号.
65-23-6
化学名:
ピリドキシン
别名:
2-メチル-3-ヒドロキシピリジン-4,5-ジメタノール;3-ヒドロキシ-2-メチルピリジン-4,5-ジメタノール;ピリビトール;4,5-ビス(ヒドロキシメチル)-2-メチルピリジン-3-オール;ビーシックス;ピリドキシン;5-ヒドロキシ-6-メチルピリジン-3,4-ジメタノール;ピリドキソール;5-ヒドロキシ-6-メチル-3,4-ピリジンジメタノール;ヒドキシン;ピリドキソル;アデルミン;5-ヒドロキシ-6-メチルピリジン-3,4-ビスメタノール;ベザチン;5-ヒドロキシ-6-メチルピリジン-3,4-ビス(メタノール);グラビドックス;3-ヒドロキシ-2-メチル-4,5-ピリジンジメタノール;ピリドキシンHCl;ビタミンB6(ピリドキシン)
英語化学名:
Pyridoxine
英語别名:
Beesix;PN HCL;VIT B6;B6-HCL;Adermin;Bezatin;Hydoxin;ADERMINE;Gravidox;Hexabion
CBNumber:
CB8197940
化学式:
C8H11NO3
分子量:
169.18
MOL File:
65-23-6.mol

ピリドキシン 物理性質

融点 :
214-215 °C(lit.)
沸点 :
298.46°C (rough estimate)
比重(密度) :
1.2435 (rough estimate)
屈折率 :
1.5100 (estimate)
貯蔵温度 :
Inert atmosphere,2-8°C
溶解性:
H2O: 0.1 g/mL at 20 °C, clear, colorless
酸解離定数(Pka):
pKa 5.00(H2O t = 25.0 I = 0.15 (mixed)) (Uncertain)
安定性::
Stable. Incompatible with strong oxidizing agents.
InChIKey:
LXNHXLLTXMVWPM-UHFFFAOYSA-N
CAS データベース:
65-23-6(CAS DataBase Reference)
NISTの化学物質情報:
2-Methyl-3-hydroxy-4,5-dihydroxymethylpyridine(65-23-6)
EPAの化学物質情報:
3,4-Pyridinedimethanol, 5-hydroxy-6-methyl- (65-23-6)

安全性情報

主な危険性  Xi
Rフレーズ  36/37/38
Sフレーズ  26-36
WGK Germany  3
RTECS 番号 UV1350000
8-10
HSコード  29362500

ピリドキシン 価格 もっと(4)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00022731 ビタミンB6(ピリドキシン)
Vitamin B6(Pyridoxine)
65-23-6 250mg ¥15600 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00022731 ビタミンB6(ピリドキシン)
Vitamin B6(Pyridoxine)
65-23-6 1g ¥31500 2021-03-23 購入
Sigma-Aldrich Japan P5669 ピリドキシン ≥98%
Pyridoxine ≥98%
65-23-6 5g ¥10200 2021-03-23 購入
Sigma-Aldrich Japan P5669 ピリドキシン ≥98%
Pyridoxine ≥98%
65-23-6 25g ¥15200 2021-03-23 購入

ピリドキシン 化学特性,用途語,生産方法

定義

本品は、ピリドキシン(*)の塩酸塩であり、次の化学式で表される。
参照表示名称:ピリドキシン

化粧品の成分用途

ヘアコンディショニング剤、皮膚コンディショニング剤

効能

ビタミンB6補充薬

化学的特性

crystalline solid

物理的性質

It is one kind of B vitamins, containing pyridoxine or pyridoxal or pyridoxamine. Appearance: colorless crystals at room temperature. Solubility: soluble in water and ethanol. Stability: stable in acid liquor but easily destroyed in alkali liquor. Pyridoxol is resistant to high temperature, but pyridoxal and pyridoxamine are not.

来歴

The discovery of vitamin was tortuous and legendary. After fat-soluble A and water soluble B were discovered by the year of 1915, the discovery of vitamins entered into a rapid developed period. In separation process of riboflavin by Kuhn and his colleagues, they noticed the unusual relationship between growth-promoting activ ity and fluorescence of extracts. Then they supposed that the existence of no fluorescent substances were very necessary for growth-promoting activity of riboflavin. And they considered this phenomenon as the evidence of a second chem ical existence in the thermostable complex. At last, they named this substance as vitamin B6 .
Vitamin B6 is widely distributed in foods, including meats, whole-grain products (especially wheat), vegetables, and nuts. In the cereal grains, vitamin B6 is concen trated primarily in the germ and aleuronic layer. Thus, the refining of grains in the production of flours, which removes much of these fractions, results in substantial reductions of vitamin B6 content. The chemical forms of vitamin B6 tend to vary among foods between plant and animal origin: plant tissues contain most pyridox ine (the free alcohol form, pyridoxol), whereas animal tissues contain most pyri doxal and pyridoxamine.

使用

antibacterial

使用

pyridoxine HCL is a skin-conditioning agent that is also widely used in hair products.

使用

Vitamin B6, a water-soluble vitamin with a solubility of 1 g in 5 ml of water. It functions in the utilization of protein and is an essential nutrient in enzyme reactions. It is necessary for proper growth. During processing, there is a loss due to leaching of the vitamin in water. It is destroyed by high temperatures, high irradiation, and exposure to light. During storage, loss increases with temperature and storage time. It is found in liver, eggs, and meats.

定義

ChEBI: A hydroxymethylpyridine with hydroxymethyl groups at positions 4 and 5, a hydroxy group at position 3 and a methyl group at position 2. The 4-methanol form of vitamin B6, it is converted intoto pyridoxal phosphate which is a coenzyme f r synthesis of amino acids, neurotransmitters, sphingolipids and aminolevulinic acid.

適応症

Vitamin B6 deficiency

brand name

Hexa-Betalin (Lilly).

世界保健機関(WHO)

Pyridoxine (vitamin B6) is listed in theWHO Model List of Essential Drugs.

一般的な説明

The discovery of vitamin B6 is generally ascribed to Paul Gy?rgy who first realized there was a vitamin that was distinctly different from vitamin B2 in 1934. Pyridoxine (PN) is the C4 hydroxymethyl derivative, pyridoxal (PL) is the C4 formyl derivative and pyridoxamine (PM) is the C4 aminomethyl derivative of 5-(hydroxymethyl)- 2-methylpyridin-3-ol). Each of these are also converted to their corresponding 5'-phosphate derivatives referred to as pyridoxine 5'-phosphate (PNP), pyridoxal 5'-phosphate (PLP), and pyridoxamine 5'-phosphate (PMP), respectively . Because of their ability to interconvert, all are considered active forms of vitamin B6 in vivo. Although PLP is the major coenzyme form, PMP can also function as a coenzyme primarily in aminotransferases. The major metabolite is 4-pyridoxic acid, which is excreted in the urine.

薬理学

The metabolically active form of vitamin B6 is pyridoxal phosphate, which serves as a coenzyme of numerous enzymes, most of which are involved in the metabolism of amino acids. Vitamin B6 functions through the following general mechanisms: decarboxylation, transamination, racemization, elimination, replacement reactions, and β-group interconversions.
Pyridoxal phosphate is practically involved in all amino acid metabolism reac tions, such as transaminations, transsulfuration, and selenoamino acid metabolism, in both their biosynthesis and their catabolism. Vitamin B6 also plays an important role in the tryptophan–niacin conversion, histamine synthesis, neurotransmitter syn thesis, and hemoglobin synthesis.
Vitamin B6 has two roles in gluconeogenesis, transaminations and glycogen uti lization. It is required for the utilization of glycogen to release glucose by serving as a coenzyme of glycogen phosphorylase.

臨床応用

Pyridoxine is indicated in the treatment and prevention of known or suspected vitamin B6 deficiency, which is most likely to occur in the setting of alcoholism in developed countries. At least seven genetic disorders that result in a vitamin B6 deficiency syndrome in the presence of an adequate dietary intake have been identified. These result from defects in enzymes that are responsible for the bioactivation or utilization of vitamin B6.

安全性プロファイル

Moderately toxic by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects: ataxia, local anesthetic, paresthesia. When heated to decomposition it emits toxic fumes of Nox

Veterinary Drugs and Treatments

Pyridoxine use in veterinary medicine is relatively infrequent. It may be of benefit in the treatment of isoniazid (INH) or crimidine (an older rodenticide) toxicity. Pyridoxine deficiency is apparently extremely rare in dogs or cats able to ingest food. Cats with severe intestinal disease may have a greater requirement for pyridoxine in their diet. Experimentally, pyridoxine has been successfully used in dogs to reduce the cutaneous toxicity associated with doxorubicin containing pegylated liposomes (Doxil?). Pyridoxine has been demonstrated to suppress the growth of feline mammary tumors (cell line FRM) in vitro.
In humans, labeled uses for pyridoxine include pyridoxine deficiency and intractable neonatal seizures secondary to pyridoxine dependency syndrome. Unlabeled uses include premenstrual syndrome (PMS), carpal tunnel syndrome, tardive dyskinesia secondary to antipsychotic drugs, nausea and vomiting in pregnancy, hyperoxaluria type 1 and oxalate kidney stones, and for the treatment of isoniazid (INH), cycloserine, hydrazine or Gyometra mushroom poisonings.

ピリドキシン 上流と下流の製品情報

原材料

準備製品


ピリドキシン 生産企業

Global( 318)Suppliers
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65-23-6(ピリドキシン)キーワード:


  • 65-23-6
  • 2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine
  • 2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin
  • 2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine
  • 2-Picoline-4,5-dimethanol, 3-hydroxy-
  • 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-
  • 3-hydroxy-2-picoline-5-dimethanol
  • 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine
  • 3-Hydroxy-4,5-dimethylol-alpha-picoline
  • 5-Hydroxy-6-mehtyl-3,4-pyridinedimethanol
  • ADEMINE HCL
  • ADERMINE
  • ADERMINE, HCL
  • ADERMINE HYDROCHLORIDE
  • 5-HYDROXY-6-METHYL-3,4-PYRIDINEDIMETHANOL HYDROCHLORIDE
  • 3-HYDROXY-4,5-DIMETHYLOL-2-PICOLINE HYDROCHLORIDE
  • 3,4-PYRIDINEDIMETHANOL, 5 HYDROXY-6-METHYL-HYDROCHLORIDE
  • 4,5-BIS(HYDROXYMETHYL)-2-METHYL-3-PYRIDINOL
  • 4,5-BIS-HYDROXYMETHYL-2-METHYL-PYRIDIN-3-OL
  • PYRIDOXINE FREE BASE
  • 4,5-Di(hydroxymethyl)-2-methylpyridin-3-ol
  • Pyridoxine,98%
  • Vitamin B6
  • VITAMIN B6(PYRIDOXINE HCL)(SH)
  • VITAMIN B6(PYRIDOXINE)(P)
  • Pyridoxol, VitaminB6
  • Pyridoxine (Vitamin B6)
  • Pyridoxine,Pyridoxol, VitaminB6
  • (5-hydroxy-6-Methylpyridine-3,4-diyl)diMethanol
  • PYRIDOXINE HYDROCHLORIDE RENAUDIN
  • Vitamin B6VVitamin B6itamin B6Vitamin B6B6
  • 2-メチル-3-ヒドロキシピリジン-4,5-ジメタノール
  • 3-ヒドロキシ-2-メチルピリジン-4,5-ジメタノール
  • ピリビトール
  • 4,5-ビス(ヒドロキシメチル)-2-メチルピリジン-3-オール
  • ビーシックス
  • ピリドキシン
  • 5-ヒドロキシ-6-メチルピリジン-3,4-ジメタノール
  • ピリドキソール
  • 5-ヒドロキシ-6-メチル-3,4-ピリジンジメタノール
  • ヒドキシン
  • ピリドキソル
  • アデルミン
  • 5-ヒドロキシ-6-メチルピリジン-3,4-ビスメタノール
  • ベザチン
  • 5-ヒドロキシ-6-メチルピリジン-3,4-ビス(メタノール)
  • グラビドックス
  • 3-ヒドロキシ-2-メチル-4,5-ピリジンジメタノール
  • ピリドキシンHCl
  • ビタミンB6(ピリドキシン)
  • ビタミンB群
  • 代謝産物
  • 代謝作用薬
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