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フェンベンダゾール

フェンベンダゾール 化学構造式
43210-67-9
CAS番号.
43210-67-9
化学名:
フェンベンダゾール
别名:
[5-(フェニルチオ)-1H-ベンゾイミダゾール-2-イル]カルバミン酸メチル;[5-(フェニルチオ)-1H-ベンゾイミダゾール-2-イル]カルバミド酸メチル;N-(5-フェニルチオ-1H-ベンゾイミダゾール-2-イル)カルバミド酸メチル;フェンビオン;パナクール;フェンベンダゾール;(5-フェニルチオ-1H-ベンゾイミダゾール-2-イル)カルバミン酸メチル;フェンベンダゾール標準品;[5-(フェニルチオ)ベンズイミダゾール-2-イル]カルバミン酸メチル
英語化学名:
Fenbendazole
英語别名:
hoe881;Axilur;Fenbion;PANACUR;HOE-881V;SAFEGARD;Fenbenazol;Febendazole;Fenbedazole;fenbendazol
CBNumber:
CB9154575
化学式:
C15H13N3O2S
分子量:
299.35
MOL File:
43210-67-9.mol

フェンベンダゾール 物理性質

融点 :
233°C
比重(密度) :
1.2767 (rough estimate)
屈折率 :
1.6740 (estimate)
貯蔵温度 :
2-8°C
外見 :
neat
酸解離定数(Pka):
10.80±0.10(Predicted)
Merck :
14,3960
BRN :
759077
CAS データベース:
43210-67-9(CAS DataBase Reference)
EPAの化学物質情報:
Carbamic acid, N-[6-(phenylthio)-1H-benzimidazol-2-yl]-, methyl ester (43210-67-9)

安全性情報

主な危険性  Xi
Rフレーズ  36/37/38
Sフレーズ  26-36-24/25
WGK Germany  2
RTECS 番号 DD6520500
HSコード  29339900

フェンベンダゾール 価格 もっと(29)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01COBOR-0660 フェンベンダゾール
Fenbendazole
43210-67-9 1g ¥3600 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01COBOR-0660 フェンベンダゾール
Fenbendazole
43210-67-9 5g ¥5400 2021-03-23 購入
東京化成工業 F0812 フェンベンダゾール >98.0%(HPLC)(N)
Fenbendazole >98.0%(HPLC)(N)
43210-67-9 25g ¥11900 2021-03-23 購入
関東化学株式会社(KANTO) 49830-22 フェンベンダゾール標準品
Fenbendazole standard
43210-67-9 100mg ¥8000 2021-03-23 購入
関東化学株式会社(KANTO) 16210-96 フェンベンダゾール標準品 >98.5%(HLC)
Fenbendazole standard >98.5%(HLC)
43210-67-9 500mg ¥7000 2021-03-23 購入

フェンベンダゾール 化学特性,用途語,生産方法

外観

白色〜ほとんど白色, 結晶性粉末〜粉末

溶解性

N,N-ジメチルホルムアミドに溶け、水、エタノール及びアセトンにほとんど溶けない。

用途

フェンベンダゾール試験用標準品。

効能

駆虫薬

説明

Fenbendazole is a benzimidazole anthelmintic. It is active against Giardia in vitro (IC50 = 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection. Fenbendazole also activates HIF-1α and prevents oxidative stress-induced death in primary neurons in vitro.

化学的特性

Off-White Solid

Originator

Panacur,Hoechst,W. Germany,1980

使用

An anthelmintic (Nematodes)

定義

ChEBI: A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted at positons 2 and 5 by (methoxycarbonyl)amino and phenylsulfanediyl groups, respectively. A broad-spectrum anthelmintic, it is used, particularly in v terinary medicine, for the treatment of nematodal infections.

Manufacturing Process

20.9 g of S-methyl-thiourea were dissolved in 27 ml of water with 13.5 ml of chloroformic acid methyl ester. Then, 45.7 ml of 25% sodium hydroxide solution were added dropwise, while stirring, at a temperature of 5°C to 10°C. After having stirred for 20 minutes, the reaction mixture was combined with 27 ml of glacial acetic acid, 100 ml of water and 29 g of 3,4-diaminodiphenyl- thioether. Stirring was continued for 90 minutes at a temperature of 85°C, during which time methyl-mercaptan was separated. After having allowed the whole to cool and stand overnight, the 5-phenylmercaptobenzimidazole- 2-methyl-carbamate that had formed was filtered off with suction. After recrystallization from a mixture of glacial acetic acid and methanol, 14 g of 4-phenylmercapto-benzimidazole-2-methyl-carbamate melting at 233°C were obtained.

brand name

Panacur (Hoechst-Roussel).

Therapeutic Function

Anthelmintic

一般的な説明

Fenbendazole is a thio substituted benzimidazole, which belongs to the group of anthelmintics. It can be widely used in veterinary medicine particularly, in the treatment of helminth infections.

Veterinary Drugs and Treatments

Fenbendazole is indicated (labeled) for the removal of the following parasites in dogs: ascarids (Toxocara canis, T. leonina), Hookworms (Ancylostoma caninum, Uncinaria stenocephala), whipworms (Trichuris vulpis), and tapeworms (Taenia pisiformis). It is not effective against Dipylidium caninum. Fenbendazole has also been used clinically to treat Capillaria aerophilia, Filaroides hirthi, and Paragonimus kellicotti infections in dogs.
Fenbendazole is indicated (labeled) for the removal of the following parasites in cattle: Adult forms of: Haemonchus contortus, Ostertagia ostertagi, Trichostrongylus axei, Bunostomum phlebotomum, Nematodirus helvetianus, Cooperia spp., Trichostrongylus colubriformis, Oesophagostomum radiatum, and Dictyocaulus vivaparus. It is also effective against most immature stages of the above listed parasites. Although not approved, it has good activity against Moniezia spp., and arrested 4th stage forms of Ostertagia ostertagi. Fenbendazole is indicated (labeled) for the removal of the following parasites in horses: large strongyles (S. edentatus, S. equinus, S. vulgaris), small strongyles (Cyathostomum spp., Cylicocylus spp., Cylicostephanus spp., Triodontophorus spp.), and pinworms (Oxyuris equi).
Fenbendazole is indicated (labeled) for the removal of the following parasites in swine: large roundworms (Ascaris suum), lungworms (Metastrongylus pair), nodular worms (Oesphagostomum dentatum, O. quadrispinolatum), small stomach worms (Hyostrongylus rubidus), whipworms (Trichuris suis), and kidney worms (Stephanurus dentatus; both mature and immature).
Although not approved, fenbendazole has been used in cats, sheep, goats, pet birds, and llamas. See Dosage section for more information.

フェンベンダゾール 上流と下流の製品情報

原材料

準備製品


フェンベンダゾール 生産企業

Global( 393)Suppliers
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Wuhan Shuokang Biological Technology Co.,Ltd
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Masteam Bio-tech Co., Ltd.
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+8613073028829
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Capot Chemical Co.,Ltd.
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+86-571-85864795 sales@capotchem.com China 20012 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
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+86-571-56059825 fandachem@gmail.com China 9165 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55

43210-67-9(フェンベンダゾール)キーワード:


  • 43210-67-9
  • hoe881
  • Fenbedazole
  • 5-(phenylthio)-2-benzimidazolecarbamic acid methyl ester
  • Methyl 5-phenylthio-1H-benaimidazol-2-yl carbamate
  • fenbendazol
  • Carbamic acid, 5-(phenylthio)-1H-benzimidazol-2-yl-, methyl ester
  • Febendazole
  • 2-(Methoxycarbonylamino)-5-(phenylthio)benzimidazole
  • 2-Benzimidazolecarbamic acid, 5-(phenylthio)-, methyl ester
  • Methyl [5-(phenylthio)-1H-benzimidazol-2-yl]carbamate
  • Fenbion
  • N-(5-Phenylthio-1H-benzimidazol-2-yl)carbamic acid methyl ester
  • [5-(Phenylthio)-1H-benzimidazol-2-yl]carbonic acid, Methyl ester
  • Fenbendazole Standard
  • methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate
  • N-[6-(phenylthio)-1H-benzimidazol-2-yl]carbamic acid methyl ester
  • Fenbendazole (100 mg)
  • Fenbendazole, USP
  • IFenbendazole
  • Fenbendazole COS/DMF/EDMF
  • Methyl [5-(Phenylthio)benzimidazol-2-yl]carbamate [5-(Phenylthio)benzimidazol-2-yl]carbamic Acid Methyl Ester
  • Methyl (6-(phenylthio)-1H-benzo[d]iMidazol-2-yl)carbaMate
  • Fenbendazole CPV2000 EP2000
  • FENBENDAZOLE VETRANAL
  • FENBENDAZOLE EP STANDARD
  • FENBENDAZOLE BP STANDARD
  • FENBENDAZOLE IMPURITY BMETHYL[5(6)-CHLOROBENZIMIDAZOL-2-YL]CARBAMATE EP STANDARD
  • FENBENDAZOLE USP STANDARD
  • FENBENDAZOLE IMPURITY AMETHYL(1H-BENZIMIDAZOL-2-YL)CARBAMATE EP STANDARD
  • FENBENDAZOLE RELATED COMPOUND BMETHYL [5(6)CHLOROBENZIMIDAZOLE-2-YL) CARBAMATE USP STANDARD
  • [5-(フェニルチオ)-1H-ベンゾイミダゾール-2-イル]カルバミン酸メチル
  • [5-(フェニルチオ)-1H-ベンゾイミダゾール-2-イル]カルバミド酸メチル
  • N-(5-フェニルチオ-1H-ベンゾイミダゾール-2-イル)カルバミド酸メチル
  • フェンビオン
  • パナクール
  • フェンベンダゾール
  • (5-フェニルチオ-1H-ベンゾイミダゾール-2-イル)カルバミン酸メチル
  • フェンベンダゾール標準品
  • [5-(フェニルチオ)ベンズイミダゾール-2-イル]カルバミン酸メチル
  • カーバメート系殺虫剤
  • 殺線虫剤
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