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亜りん酸ジメチル

亜りん酸ジメチル 化学構造式
868-85-9
CAS番号.
868-85-9
化学名:
亜りん酸ジメチル
别名:
亜りん酸ジメチル;ジメチルホスファイト;亜りん酸水素ジメチル;ホスホン酸ジメチル;ジメチルホスホナート;ジメトキシホスフィンオキシド;ジメチル水素亜リン酸塩;ジメチル=ホスホナート
英語化学名:
Dimethyl phosphite
英語别名:
(CH3O)2PHO;NCI-C54773;Dimethylfosfit;Dimethylfosfonat;Dimethylphosphit;DIMETHYL PHOSPHITE;Dimethyl phosphonat;DIMETHYL PHOSPHONATE;dimethylacidphosphite;Dimethylphosphite,98+%
CBNumber:
CB9248221
化学式:
C2H7O3P
分子量:
110.05
MOL File:
868-85-9.mol

亜りん酸ジメチル 物理性質

沸点 :
170-171 °C(lit.)
比重(密度) :
1.2 g/mL at 25 °C(lit.)
屈折率 :
n20/D 1.402(lit.)
闪点 :
71 °C
外見 :
Colorless liquid with a mild odor
水溶解度 :
Soluble in water.
Sensitive :
Moisture Sensitive
BRN :
1697490
安定性::
Stable. Moisture sensitive. Incompatible with water, strong oxidizing agents, acid chlorides, strong bases.
CAS データベース:
868-85-9(CAS DataBase Reference)
NISTの化学物質情報:
Phosphonic acid, dimethyl ester(868-85-9)
IARC:
3 (Vol. 48, 71) 1999
EPAの化学物質情報:
Dimethyl phosphite (868-85-9)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn
Rフレーズ  21-36-10-68-52/53-43-40
Sフレーズ  26-36/37-61
RIDADR  UN 3278 6.1/PG 3
WGK Germany  1
RTECS 番号 SZ7710000
TSCA  Yes
国連危険物分類  3.2
容器等級  III
HSコード  29209013
有毒物質データの 868-85-9(Hazardous Substances Data)
消防法 危-4-3-III
化審法 (2)-2001, (2)-1961
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H227 引火性液体 引火性液体 4 警告 P210, P280, P370+P378, P403+P235,P501
H303 飲み込むと有害のおそれ 急性毒性、経口 5 P312
H311 皮膚に接触すると有毒 急性毒性、経皮 3 危険 P280, P302+P352, P312, P322, P361,P363, P405, P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H317 アレルギー性皮膚反応を起こすおそれ 感作性、皮膚 1 警告 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
H341 遺伝性疾患のおそれの疑い 生殖細胞変異原性 2 警告 P201,P202, P281, P308+P313, P405,P501
H351 発がんのおそれの疑い 発がん性 2 警告 P201, P202, P281, P308+P313, P405,P501
H412 長期的影響により水生生物に有害 水生環境有害性、慢性毒性 3 P273, P501
注意書き
P201 使用前に取扱説明書を入手すること。
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P273 環境への放出を避けること。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P405 施錠して保管すること。

亜りん酸ジメチル 価格 もっと(3)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
東京化成工業 D0786 亜りん酸ジメチル >98.0%(T)
Dimethyl Phosphite >98.0%(T)
868-85-9 25mL ¥2800 2021-03-23 購入
Sigma-Aldrich Japan D178454 亜リン酸ジメチル 98%
Dimethyl phosphite 98%
868-85-9 500g ¥8720 2021-03-23 購入
Sigma-Aldrich Japan D178454 亜リン酸ジメチル 98%
Dimethyl phosphite 98%
868-85-9 25g ¥2410 2021-03-23 購入

亜りん酸ジメチル MSDS


Dimethyl phosphite

亜りん酸ジメチル 化学特性,用途語,生産方法

用途

主たる用途はNYLON 6 FIBRESの難燃剤[IARC 71 (1999)]である。

化学的特性

colourless liquid

使用

  1. Dimethyl Phosphite(DMP)is used as a reagent in the synthesis of 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors.
  2. It is also used as a reagent in the synthesis of estafiatin phosphonate derivatives which exhibit antibacterial and antifungal activity.
  3. Dimethyl Phosphite is a degradation product of the pesticides trichlorphon and malathion and may be released into the envionment following their application. It is a contaminant (approxiately 2%) in the chemical intermediate triethyl phosphite, which hydrolyses readily to dimethyl hydrogen phosphite in the presence of moist air or water.
  4. Dimethyl Phosphite is used as a flame retardant on Nylon 6 fibres  and, in combination with guanidine and formaldehyde, to impart flame and crease resistance to cotton textiles. The compound is also used to increase fire resistance to cellulosic textiles, acrolein-grafted polyamide fibres and y-irdiated polyethylene.
  5. lt is used as a lubricant additive, as a chemical intermediate in the production of organophosphorous pesticides and as an adhesive.
  6. Dimethyl Phosphite has also been used as a stabilizer in oil and plaster and, in combination with pyroctechol, as a corrosion inhibitor on steel.

使用

As a flame retardant on Nylon 6 fibers; intermediate in the production of pesticides and herbicides; as a stabilizer in oil and plaster; an additive to lubricants

主な応用

DMP is a basic chemical which is used industrially as an intermediate. Because of its reactivity
DMP participates in a large number of chemical reactions:
  • Addition to oxo compounds
  • Addition to oxo compounds with subsequent condensation e.g. with amines
  • Oxidation with oxygen or chlorine
  • Addition to alkenes
Due to these properties DMP is used as an intermediate for the manufacturing of
  • water treatment chemicals e.g. corrosion inhibitors for cooling-water circuits (about 50 %)
  • pesticides and pharmaceuticals (about 20 %)
  • flame retardants and other specialities (about 15 %)
  • textile finishing products (about 15 %)

Synthesis Reference(s)

Canadian Journal of Chemistry, 34, p. 1819, 1956 DOI: 10.1139/v56-235

健康ハザード

Dimethyl Phosphite (DMP) is rapidly absorbed via the oral and dermal routes. The main metabolic pathway in rodents is demethylation to monomethyl hydrogen phosphite (MMP) and further oxidation to CO2. DMP was mainly eliminated via urine and expired air. Over the studied dose range between 10 and 200 mg/kg bw and 5 x 200 mg/kg bw, respectively, only little evidence of bioaccumulation or saturation of absorption and elimination was observed. The only difference in studied toxicokinetics between rats and mice was the more rapid metabolism and elimination in mice.
An inhalation LC50 value is not available, but an exposure of 7100 mg/m³ (concentration estimated based on air flow and net loss of material) over 6 hours was not lethal for rats, mice and guinea pigs. Clinical signs were observed in mice only, and included occasionally laboured respiration after approximately 2 hours of exposure and ptosis after 5 hours. The acute dermal LD50 was 681 mg/kg bw (rabbits). Signs of intoxication were depression, ptosis, labored respiration, ataxia and placidity. The acute oral LD50 values were: 3283 mg/kg bw for male rats, 3040 mg/kg bw for female rats, 2815 mg/kg bw for male mice, and between 2150 and 3160 mg/kg bw for female mice. Clinical signs were inactivity, weakness, prostration and shallow breathing at doses near to or exceeding the LD50 values. White opaque eyes were seen in male mice.
Dimethyl Phosphite is irritating to the skin and eyes of rabbits. After prolonged or repeated exposures moderate to severe irritation of skin and mucosa was observed in rats. No sensitisation studies are available.
Proposed metabolic pathways of DMP in rats and mice
Proposed metabolic pathways of DMP in rats and mice (Nomeir and Matthews, 1997).

安全性プロファイル

Suspected carcinogen with experimental carcinogenic data. Moderately toxic by ingestion and skin contact. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of POx

Carcinogenicity

Dimethyl hydrogen phosphite was not mutagenic to several strains of Salmonella typhimurium, but it did cause sister chromatid exchanges and chromosomal aberrations in the Chinese hamster CHO line.
An ACGIH threshold limit value (TLV) has not been established for dimethyl hydrogen phosphite.

亜りん酸ジメチル 上流と下流の製品情報

原材料

準備製品


亜りん酸ジメチル 生産企業

Global( 220)Suppliers
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868-85-9(亜りん酸ジメチル)キーワード:


  • 868-85-9
  • (CH3O)2PHO
  • bis(hydroxymethyl)phosphineoxide
  • Dimethoxyphosphine oxide
  • dimethoxyphosphineoxide
  • Dimethyl acid phosphite
  • Dimethyl ester of phosphonic acid
  • dimethylacidphosphite
  • Dimethylester kyseliny fosforite
  • DIMETHYL PHOSPHITE
  • DIMETHYL PHOSPHONATE
  • DIMETHYL HYDROGEN PHOSPHITE
  • methylphosphonate((meo)2hpo)
  • NCI-C54773
  • O,O-Dimethyl phosphonate
  • PHOSPHONIC ACID DIMETHYL ESTER
  • PHOSPHOROUS ACID DIMETHYL ESTER
  • DIMETHYL PHOSPHITE 99% (GC)
  • Dimethylphosphite,98+%
  • DIMETHYLHYDROGENPHOSPHIT
  • Phosphonsuredimethylester
  • Phosphonic acid dimethyl
  • Phosphorous acid hydrogen dimethyl ester
  • O,O-dimethyl phosphite
  • dimethylesterkyselinifosforite(czech)
  • dimethylesterkyselinyfosforite
  • Dimethylfosfit
  • Dimethylfosfonat
  • dimethylhydrogenphosphonate
  • Dimethylphosphit
  • dimethylphosphorousacid
  • 亜りん酸ジメチル
  • ジメチルホスファイト
  • 亜りん酸水素ジメチル
  • ホスホン酸ジメチル
  • ジメチルホスホナート
  • ジメトキシホスフィンオキシド
  • ジメチル水素亜リン酸塩
  • ジメチル=ホスホナート
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